Search Results - "McGregor, Nicholas G S"

Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α‑l‑Arabinofuranosidases by McGregor, Nicholas G. S, Artola, Marta, Nin-Hill, Alba, Linzel, Daniël, Haon, Mireille, Reijngoud, Jos, Ram, Arthur, Rosso, Marie-Noëlle, van der Marel, Gijsbert A, Codée, Jeroen D. C, van Wezel, Gilles P, Berrin, Jean-Guy, Rovira, Carme, Overkleeft, Herman S, Davies, Gideon J

“…Identifying and characterizing the enzymes responsible for an observed activity within a complex eukaryotic catabolic system remains one of the most…”
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Whole genome structural predictions reveal hidden diversity in putative oxidative enzymes of the lignocellulose-degrading ascomycete Parascedosporium putredinis NO1 by Scott, Conor J R, Leadbeater, Daniel R, Oates, Nicola C, James, Sally R, Newling, Katherine, Li, Yi, McGregor, Nicholas G S, Bird, Susannah, Bruce, Neil C

“…An annotated reference genome has revealed NO1 as a useful resource for the identification of new lignocellulose-degrading enzymes for biorefining of woody…”
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Parascedosporium putredinis NO1 tailors its secretome for different lignocellulosic substrates by Scott, Conor J R, McGregor, Nicholas G S, Leadbeater, Daniel R, Oates, Nicola C, Hoßbach, Janina, Abood, Amira, Setchfield, Alexander, Dowle, Adam, Overkleeft, Herman S, Davies, Gideon J, Bruce, Neil C

“…NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and…”
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Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes by McGregor, Nicholas G S, de Boer, Casper, Santos, Mikhaaeel, Haon, Mireille, Navarro, David, Schroder, Sybrin, Berrin, Jean-Guy, Overkleeft, Herman S, Davies, Gideon J

“…Fungal saccharification of lignocellulosic biomass occurs concurrently with the secretion of a diverse collection of proteins, together functioning as a…”
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A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System by McGregor, Nicholas G. S., de Boer, Casper, Foucart, Quentin P. O., Beenakker, Thomas, Offen, Wendy A., Codée, Jeroen D. C., Willems, Lianne I., Overkleeft, Herman S., Davies, Gideon J.

“…Bacteria and yeasts grow on biomass polysaccharides by expressing and excreting a complex array of glycoside hydrolase (GH) enzymes. Identification and…”
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Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases by de Boer, Casper, McGregor, Nicholas G. S, Peterse, Evert, Schröder, Sybrin P, Florea, Bogdan I, Jiang, Jianbing, Reijngoud, Jos, Ram, Arthur F. J, van Wezel, Gilles P, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S, Davies, Gideon J

“…Cellulases and related β-1,4-glucanases are essential components of lignocellulose-degrading enzyme mixtures. The detection of β-1,4-glucanase activity…”
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Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases by de Boer, Casper, McGregor, Nicholas G. S, Peterse, Evert, Schröder, Sybrin P, Florea, Bogdan I, Jiang, Jianbing, Reijngoud, Jos, Ram, Arthur F. J, van Wezel, Gilles P, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S, Davies, Gideon J

“…Correction for 'Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases' by Casper de Boer et al. , RSC Chem. Biol. , 2020, 1 ,…”
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Self-assembly of mixed-linkage glucan hydrogels formed following EG16 digestion by McGregor, Nicholas G.S., Penttilä, Paavo, Pitkänen, Leena, Mohammadi, Pezhman, Vuorte, Maisa, Igarashi, Kiyohiko, Arola, Suvi

“…Mixed-linkage glucans are major components of grassy cell-walls and cereal endosperm. Recently identified plant endo-β-glucanase from the EG16 family cleaves…”
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Detecting and identifying glycoside hydrolases using cyclophellitol-derived activity-based probes by McGregor, Nicholas G S, Overkleeft, Herman S, Davies, Gideon J

“…The ability to detect active enzymes in a complex mixture of folded proteins (e.g., secretome, cell lysate) generally relies on observations of catalytic…”
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Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor by McGregor, Nicholas G. S., Coines, Joan, Borlandelli, Valentina, Amaki, Satoko, Artola, Marta, Nin‐Hill, Alba, Linzel, Daniël, Yamada, Chihaya, Arakawa, Takatoshi, Ishiwata, Akihiro, Ito, Yukishige, Marel, Gijsbert A., Codée, Jeroen D. C., Fushinobu, Shinya, Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J.

“…The recent discovery of zinc‐dependent retaining glycoside hydrolases (GHs), with active sites built around a Zn(Cys)3(Glu) coordination complex, has presented…”
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Synthesis of broad-specificity activity-based probes for exo -β-mannosidases by McGregor, Nicholas G S, Kuo, Chi-Lin, Beenakker, Thomas J M, Wong, Chun-Sing, Offen, Wendy A, Armstrong, Zachary, Florea, Bogdan I, Codée, Jeroen D C, Overkleeft, Herman S, Aerts, Johannes M F G, Davies, Gideon J

“…-β-mannosidases are a broad class of stereochemically retaining hydrolases that are essential for the breakdown of complex carbohydrate substrates found in all…”
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Structure of a GH51 α‐l‐arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi by McGregor, Nicholas G. S., Turkenburg, Johan P., Mørkeberg Krogh, Kristian B. R., Nielsen, Jens Erik, Artola, Marta, Stubbs, Keith A., Overkleeft, Herman S., Davies, Gideon J.

“…α‐l‐Arabinofuranosidases from glycoside hydrolase family 51 use a stereochemically retaining hydrolytic mechanism to liberate nonreducing terminal…”
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Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor by McGregor, Nicholas G. S., Coines, Joan, Borlandelli, Valentina, Amaki, Satoko, Artola, Marta, Nin‐Hill, Alba, Linzel, Daniël, Yamada, Chihaya, Arakawa, Takatoshi, Ishiwata, Akihiro, Ito, Yukishige, Marel, Gijsbert A., Codée, Jeroen D. C., Fushinobu, Shinya, Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J.

“…The recent discovery of zinc‐dependent retaining glycoside hydrolases (GHs), with active sites built around a Zn(Cys)3(Glu) coordination complex, has presented…”
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Family GH157 enzyme exhibits broad linkage tolerance and a dual endo/exo-β-glucanase activity on β-glucans by Caseiro, Catarina, McGregor, Nicholas G.S., Alves, Victor Diogo, Carvalho, Ana Luísa, Romão, Maria João, Davies, Gideon J., Fontes, Carlos M.G.A., Bule, Pedro

“…The structural and chemical diversity of β-glucans is reflected on the variety of essential biological roles tackled by these polysaccharides. This natural…”
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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes by Schröder, Sybrin P, de Boer, Casper, McGregor, Nicholas G. S, Rowland, Rhianna J, Moroz, Olga, Blagova, Elena, Reijngoud, Jos, Arentshorst, Mark, Osborn, David, Morant, Marc D, Abbate, Eric, Stringer, Mary A, Krogh, Kristian B. R. M, Raich, Lluís, Rovira, Carme, Berrin, Jean-Guy, van Wezel, Gilles P, Ram, Arthur F. J, Florea, Bogdan I, van der Marel, Gijsbert A, Codée, Jeroen D. C, Wilson, Keith S, Wu, Liang, Davies, Gideon J, Overkleeft, Herman S

“…Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels and other commodities. However, the extraordinary recalcitrance…”
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