Search Results - "McGregor, Douglas B."

4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans by Cohen, Samuel M., Boobis, Alan R., (Bette) Meek, M. E., Preston, R. Julian, McGregor, Douglas B.

“…The IPCS Human Relevance Framework was evaluated for a DNA-reactive (genotoxic) carcinogen, 4-aminobiphenyl, based on a wealth of data in animals and humans…”
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Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents by Cruzan, George, Borghoff, Susan J., de Peyster, Ann, Hard, Gordon C., McClain, Michael, McGregor, Douglas B., Thomas, Michael G.

“…There are no reports of studies that evaluate if methyl tertiary-butyl ether (MTBE) exposure causes cancer in humans. This evaluation of MTBE carcinogenicity…”
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Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity by Hard, Gordon C, Banton, Marcy I, Bretzlaff, Robert S, Dekant, Wolfgang, Fowles, Jefferson R, Mallett, Anthony K, McGregor, Douglas B, Roberts, Kathleen M, Sielken, Jr, Robert L, Valdez-Flores, Ciriaco, Cohen, Samuel M

“…Chronic progressive nephropathy (CPN) is a spontaneous renal disease of rats which can be a serious confounder in toxicology studies. It is a progressive…”
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Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations by Bus, James S., Banton, Marcy I., Faber, Willem D., Kirman, Christopher R., McGregor, Douglas B., Pourreau, Daniel B.

“…Abstract A screening level risk assessment has been performed for tertiary-butyl acetate (TBAC) examining its primary uses as a solvent in industrial and…”
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An IARC Evaluation of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans as Risk Factors in Human Carcinogenesis by McGregor, Douglas B., Partensky, Christiane, Wilbourn, Julian, Rice, Jerry M.

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Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals by McGregor, D B, Brown, A, Cattanach, P, Edwards, I, McBride, D, Caspary, W J

“…Eighteen chemicals were tested for their mutagenic potential in the L5178Y tk+/- mouse lymphoma cell forward mutation assay by the use of procedures based upon…”
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An IARC Evaluation of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans as Risk Factors in Human Carcinogenesis by McGregor, Douglas B., Partensky, Christiane, Wilbourn, Julian, Rice, Jerry M.

“…The International Agency for Research on Cancer (IARC) Monographs program reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated…”
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Meeting of the IARC Working Group on Occupational Exposures of Hairdressers and Barbers and on Some Colorings and Dyestuffs by Vainio, Harri, McGregor, Douglas B, Heseltine, Elisabeth

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The effect of solvents upon the yield of revertants in the Salmonella/activation mutagenicity assay by Anderson, D, McGregor, D B

“…The effects of dimethylsulphoxide and acetone have been investigated in the Salmonella/activation mutagenicity assay using 2-aminoanthracene and benzo(a)pyrene…”
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Comet assay responses as indicators of carcinogen exposure by Anderson, Diana, Yu, Tian-Wei, McGregor, Douglas B.

“…Over 200 agents/factors have been examined in the single cell gel electrophoresis assay, more commonly known as the Comet assay, performed either in vitro or…”
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Rodent tumors of urinary bladder, renal cortex, and thyroid gland in IARC monographs evaluations of carcinogenic risk to humans by RICE, J. M, BAAN, R. A, BLETTNER, M, GENEVOIS-CHARMEAU, C, GROSSE, Y, MCGREGOR, D. B, PARTENSKY, C, WILBOURN, J. D

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Meeting report by McGregor, Douglas B, Heseltine, Elisabeth, Møller, Henrik

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IARC Reevaluates Silica and Related Substances by Wilbourn, Julian D., McGregor, Douglas B., Partensky, Christiane, Rice, Jerry M.

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Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals by McGregor, D B, Brown, A G, Howgate, S, McBride, D, Riach, C, Caspary, W J

“…Twenty-seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay using procedures based upon…”
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Dry cleaning, some solvents used in dry cleaning and other industrial chemicals by McGregor, Douglas B, Heseltine, Elisabeth, Møller, Henrik

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Chemicals classified by IARC: an investigation of some of their toxicological characteristics by McGregor, D B

“…Chemicals classified by the IARC to its Groups 1, 2A, 2B and 3 were examined in an attempt to identify characteristics of their behaviour in experimental…”
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Effects of plate preparation on results in microbial mutation assays by Majeska, J B, McGregor, D B

“…Glucose autoclaved in an alkaline phosphate solution (heated glucose+salts, HGS) results in the production of a moiety that is nonmutagenic but can interact…”
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Genotoxicity of Glycol Ethers by McGregor, Douglas B.

“…The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members…”
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TFT and 6TG resistance of mouse lymphoma cells to analogs of azacytidine by McGregor, D B, Brown, A G, Cattanach, P, Shepherd, W, Riach, C, Daston, D S, Caspary, W J

“…5-Azacytidine (5-aza-CR) and six of its analogs were examined for their ability to induce trifluorothymidine (TFT) and/or 6-thioguanine (6TG) resistance in…”
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Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagens by McGregor, D B, Riach, C G, Brown, A, Edwards, I, Reynolds, D, West, K, Willington, S

“…Using the L5178Y mouse lymphoma cell thymidine kinase locus and the Salmonella his locus assays, the mutagenic potentials of several catecholamines and related…”
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