Search Results - "McGrail, Kieran"

Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform by Wan, Hao, Merriman, Chengfeng, Atkinson, Mark A., Wasserfall, Clive H., Mcgrail, Kieran M., Liang, Yongye, Fu, Dax, Dai, Hongjie

“…Identified as a major biomarker for type 1 diabetes (T1D) diagnosis, zinc transporter 8 autoantibody (ZnT8A) has shown promise for staging disease risk and…”
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Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis by Williams, MacKenzie D, Bacher, Rhonda, Perry, Daniel J, Grace, C Ramsey, McGrail, Kieran M, Posgai, Amanda L, Muir, Andrew, Chamala, Srikar, Haller, Michael J, Schatz, Desmond A, Brusko, Todd M, Atkinson, Mark A, Wasserfall, Clive H

“…We and others previously demonstrated that a type 1 diabetes genetic risk score (GRS) improves the ability to predict disease progression and onset in at-risk…”
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Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes by Beam, Craig A., Beli, Eleni, Wasserfall, Clive H., Woerner, Stephanie E., Legge, Megan T., Evans-Molina, Carmella, McGrail, Kieran M., Silk, Ryan, Grant, Maria B., Atkinson, Mark A., DiMeglio, Linda A.

“…Aims/hypothesis The circadian clock influences both diabetes and immunity. Our goal in this study was to characterise more thoroughly the circadian patterns of…”
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A genomic data archive from the Network for Pancreatic Organ donors with Diabetes by Perry, Daniel J., Shapiro, Melanie R., Chamberlain, Sonya W., Kusmartseva, Irina, Chamala, Srikar, Balzano-Nogueira, Leandro, Yang, Mingder, Brant, Jason O., Brusko, Maigan, Williams, MacKenzie D., McGrail, Kieran M., McNichols, James, Peters, Leeana D., Posgai, Amanda L., Kaddis, John S., Mathews, Clayton E., Wasserfall, Clive H., Webb-Robertson, Bobbie-Jo M., Campbell-Thompson, Martha, Schatz, Desmond, Evans-Molina, Carmella, Pugliese, Alberto, Concannon, Patrick, Anderson, Mark S., German, Michael S., Chamberlain, Chester E., Atkinson, Mark A., Brusko, Todd M.

“…The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type…”
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1729-P: Circadian Patterns of Autoimmune Components in the Blood of Persons with Type 1 Diabetes: Implications for the Timing of Blood Sampling by BELI, ELENI, DIMEGLIO, LINDA, WOERNER, STEPHANIE, EVANS-MOLINA, CARMELLA, MCGRAIL, KIERAN M., WASSERFALL, CLIVE, ATKINSON, MARK A., BEAM, CRAIG

“…Purpose: Immune populations and cytokines are known to exhibit distinct circadian ("daily") variations. We sought to characterize circadian-related immune…”
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No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes by BRUSKO, Todd, WASSERFALL, Clive, ATKINSON, Mark, MCGRAIL, Kieran, SCHATZ, Richard, LEE VIENER, Hilla, SCHATZ, Desmond, HALLER, Michael, ROCKELL, Jennifer, GOTTLIEB, Peter, CLARE-SALZLER, Michael

“…No Alterations in the Frequency of FOXP3 + Regulatory T-Cells in Type 1 Diabetes Todd Brusko 1 , Clive Wasserfall 1 , Kieran McGrail 1 , Richard Schatz 1 ,…”
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Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes by Haller, Michael J, Wasserfall, Clive H, McGrail, Kieran M, Cintron, Miriam, Brusko, Todd M, Wingard, John R, Kelly, Susan S, Shuster, Jonathan J, Atkinson, Mark A, Schatz, Desmond A

“…OBJECTIVE: Interest continues to grow regarding the therapeutic potential for umbilical cord blood therapies to modulate autoimmune disease. We conducted an…”
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Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide by Haller, Michael J, Wasserfall, Clive H, Hulme, Maigan A, Cintron, Miriam, Brusko, Todd M, McGrail, Kieran M, Sumrall, Theresa M, Wingard, John R, Theriaque, Douglas W, Shuster, Jonathan J, Atkinson, Mark A, Schatz, Desmond A

“…OBJECTIVE: We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having…”
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339 A serum exocrine enzyme as a biomarker of response to immunotherapy in type 1 diabetes by Bruggeman, Brittany S, McGrail, Kieran, Gonzalez, Nicole, Wasserfall, Clive, Campbell-Thompson, Martha, Atkinson, Mark, Haller, Michael, Schatz, Desmond

“…OBJECTIVES/GOALS: We assessed the relationship between C-peptide preservation and a serum exocrine pancreatic enzyme (trypsin) in a recently concluded clinical…”
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Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area by Xue, Song, PhD, Wasserfall, Clive, MS, Parker, Matthew, BS, McGrail, Sean, BS, McGrail, Kieran, BS, Campbell-Thompson, Martha, DVM, PhD, Schatz, Desmond A., MD, Atkinson, Mark A., PhD, Haller, Michael J., MD

“…Abstract Objective The notion of combining immunomodulatory agents with the incretin exendin-4 (Ex-4) has seen considerable favor as a potential therapy for…”
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1623-P: Artificial Intelligence with QuPATH in Pancreatic Cell Classification by Guyot, Michael, Williams, MacKenzie D, Bumgarner, Benjamin M, McGrail, Kieran M, Campbell-Thompson, Martha, Haller, Michael J, Bruggeman, Brittany S

“…We developed Artificial Intelligence classification algorithms in QuPATH containing both supervised and unsupervised components to quantify and classify the…”
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Regulatory T Cells Require Serum for Suppression of Effector T Cell Proliferation and Express Stable Membrane-bound CD25 by Brusko, Todd, Postdoctoral Associate, University of Florida, College of Medicine, Gainesville, FL, Wasserfall, Clive, Biological Scientist, University of Florida, College of Medicine, Department of Pathology, Gainesville, FL, McGrail, Kieran, Laboratory Technician, University of Florida, College of Medicine, Department of Pathology, Gainesville, FL, Moore, Marcus, Laboratory Technician, University of Florida, College of Medicine, Department of Pathology, Gainesville, FL, Huegel, Alyssa, Laboratory Technician, University of Florida, College of Medicine, Department of Pathology, Gainesville, FL, Schatz, Desmond, Professor of Pediatric Medicine, University of Florida, College of Medicine, Department of Pediatrics, Gainesville, FL, Atkinson, Mark, Professor, University of Florida, College of Medicine, Department of Pathology, Gainesville, FL

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Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size by Ross, James J, Wasserfall, Clive H, Bacher, Rhonda, Perry, Daniel J, McGrail, Kieran, Posgai, Amanda L, Dong, Xiaoru, Muir, Andrew, Li, Xia, Campbell-Thompson, Martha, Brusko, Todd M, Schatz, Desmond A, Haller, Michael J, Atkinson, Mark A

“…Exocrine pancreas abnormalities are increasingly recognized as features of type 1 diabetes. We previously reported reduced serum trypsinogen levels and in a…”
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Serum Trypsinogen Levels in Type 1 Diabetes by Li, Xia, Campbell-Thompson, Martha, Wasserfall, Clive H, McGrail, Kieran, Posgai, Amanda, Schultz, Andrew R, Brusko, Todd M, Shuster, Jonathan, Liang, Faming, Muir, Andrew, Schatz, Desmond, Haller, Michael J, Atkinson, Mark A

“…The pancreas in type 1 diabetes exhibits decreased size (weight/volume) and abnormal exocrine morphology. Serum trypsinogen levels are an established marker of…”
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Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D by ROSS, JAMES J., WASSERFALL, CLIVE, PERRY, DANIEL J., MCGRAIL, KIERAN M., POSGAI, AMANDA L., BRUSKO, TODD M., SCHATZ, DESMOND, HALLER, MICHAEL J., ATKINSON, MARK A.

“…Recent studies demonstrated reduced serum trypsinogen levels as well as pancreatic weight/volume in patients with type 1 diabetes (T1D) and…”
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Exendin-4 Therapy in NOD Mice with New-Onset Diabetes Increases Regulatory T Cell Frequency by Xue, Song, Wasserfall, Clive H., Parker, Matthew, Brusko, Todd M., McGrail, Sean, McGrail, Kieran, Moore, Marcus, Campbell-Thompson, Martha, Schatz, Desmond A., Atkinson, Mark A., Haller, Michael J.

“…Recent studies, albeit controversial, have suggested that the incretin exendin‐4 (Ex‐4) is capable of inducing β cell proliferation in vivo. Furthermore, this…”
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No Alterations in the Frequency of FOXP3^sup +^ Regulatory T-Cells in Type 1 Diabetes by Brusko, Todd, Wasserfall, Clive, McGrail, Kieran, Schatz, Richard

“…Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes have used…”
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No Alterations in the Frequency of FOXP3 super(+) Regulatory T-Cells in Type 1 Diabetes by Brusko, Todd, Wasserfall, Clive, McGrail, Kieran, Schatz, Richard, Viener, Hilla Lee, Schatz, Desmond, Haller, Michael, Rockell, Jennifer, Gottlieb, Peter, Clare-Salzler, Michael, Atkinson, Mark

“…Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes have used…”
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No alterations in the frequency of FOXP[3.sup.+] regulatory T-cells in type 1 diabetes by Brusko, Todd, Wasserfall, Clive, McGrail, Kieran, Schatz, Richard, Viener, Hilla Lee, Schatz, Desmond, Haller, Michael, Rockell, Jennifer, Gottlieb, Peter, Clare-Salzler, Michael, Atkinson, Mark

“…Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes have used…”
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