Search Results - "McGown, Gail"

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions by Wilkinson, Oliver J, Latypov, Vitaly, Tubbs, Julie L, Millington, Christopher L, Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J, Connolly, Bernard A, Grasby, Jane A, Masui, Ryoji, Hunter, Christopher A, Tainer, John A, Margison, Geoffrey P, Williams, David M

“…Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA…”
Get full text

Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines by Latypov, Vitaly F., Tubbs, Julie L., Watson, Amanda J., Marriott, Andrew S., McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J., Senthong, Pattama, Butt, Amna, Arvai, Andrew S., Millington, Christopher L., Povey, Andrew C., Williams, David M., Santibanez-Koref, Mauro F., Tainer, John A., Margison, Geoffrey P.

“…Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially…”
Get full text

Tumor O6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib by Watson, Amanda J, Sabharwal, Ami, Thorncroft, Mary, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P, Middleton, Mark R

“…Purpose: A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O 6 -methylguanine-DNA…”
Get full text

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1 by PLUMMER, E. Ruth, MIDDLETON, Mark R, BODDY, Alan V, CALVERT, A. Hilary, HARRIS, Adrian L, NEWELL, David R, CURTIN, Nicola J, JONES, Christopher, OLSEN, Anna, HICKSON, Ian, MCHUGH, Peter, MARGISON, Geoffrey P, MCGOWN, Gail, THORNCROFT, Mary, WATSON, Amanda J

“…Purpose: Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is repaired by O 6 -alkylguanine alkyltransferase (ATase) and…”
Get full text

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients by Agnihotri, Sameer, Gajadhar, Aaron S, Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L, Mischel, Paul S, Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L, Sarkaria, Jann N, Margison, Geoffrey P, Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit

“…Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and…”
Get full text

Flipping of alkylated DNA damage bridges base and nucleotide excision repair by Butt, Amna, Williams, David M, Verbeek, Barbara, Tubbs, Julie L, Watson, Amanda J, Kroeger, Matthew D, Peterson, Lisa A, Kraehenbuehl, Rolf, Santibanez-Koref, Mauro F, Arvai, Andrew S, Kanugula, Sreenivas, Fried, Michael G, Melikishvili, Manana, Marriott, Andrew, Latypov, Vitaly, Fleck, Oliver, Margison, Geoffrey P, Pegg, Anthony E, Tainer, John A, McGown, Gail, Millington, Christopher, Thorncroft, Mary

“…Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy target O 6 -alkylguanine-DNA alkyltransferase (AGT) and…”
Get full text

Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines by Latypov, Vitaly F, Tubbs, Julie L, Watson, Amanda J, Marriott, Andrew S, McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J, Senthong, Pattama, Butt, Amna, Arvai, Andrew S, Millington, Christopher L, Povey, Andrew C, Williams, David M, Santibanez-Koref, Mauro F, Tainer, John A, Margison, Geoffrey P

“…Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially…”
Get full text

Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib by Watson, Amanda J, Sabharwal, Ami, Thorncroft, Mary, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P, Middleton, Mark R

“…A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O(6)-methylguanine-DNA methyltransferase…”
Get full text

Tumor O 6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib by Watson, Amanda J., Sabharwal, Ami, Thorncroft, Mary, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P., Middleton, Mark R.

“…Purpose: A major mechanism of resistance to chlorethylnitrosureas and methylating agents involves the DNA repair protein O6-methylguanine-DNA methyltransferase…”
Get full text

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients by Agnihotri, Sameer, Gajadhar, Aaron S., Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L., Mischel, Paul S., Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L., Sarkaria, Jann N., Margison, Geoffrey P., Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit

Get full text

Are There Low-Penetrance TP53 Alleles? Evidence from Childhood Adrenocortical Tumors by Varley, Jennifer M., McGown, Gail, Thorncroft, Mary, James, Louise A., Margison, Geoffrey P., Forster, Gill, Evans, D. Gareth R., Harris, Martin, Kelsey, Anna M., Birch, Jillian M.

“…We have analyzed a panel of 14 cases of childhood adrenocortical tumors unselected for family history and have identified germline TP53 mutations in >80%,…”
Get full text

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-[pi] interactions by Wilkinson, Oliver J, Latypov, Vitaly, Tubbs, Julie L, Millington, Christopher L, Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J, Connolly, Bernard A, Grasby, Jane A, Masui, Ryoji, Hunter, Christopher A, Tainer, John A, Margison, Geoffrey P, Williams, David M

“…Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA…”
Get full text

Germ-line mutations of TP53 in Li-Fraumeni families : An extended study of 39 families by VARLEY, J. M, MCGOWN, G, THORNCROFT, M, SANTIBANEZ-KOREF, M. F, KELSEY, A. M, TRICKER, K. J, EVANS, D. G. R, BIRCH, J. M

“…We have previously reported on the analysis of TP53 coding mutations in 12 classic Li-Fraumeni syndrome (LFS) families plus 9 families that were…”
Get full text

Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O 6 ‐alkylguanine–DNA alkyltransferase by Crosbie, Philip A.J., McGown, Gail, Thorncroft, Mary R., O'Donnell, Paul N.S., Barber, Philip V., Lewis, Sarah J., Harrison, Kathryn L., Agius, Raymond M., Santibáñez‐Koref, Mauro F., Margison, Geoffrey P., Povey, Andrew C.

“…The association between lung cancer risk and 2 polymorphisms, rs12268840 and rs2308327 (codon K178R), in the DNA repair protein, O 6 ‐alkylguanine–DNA…”
Get full text

Alkylated DNA damage flipping bridges base and nucleotide excision repair by Tubbs, Julie L., Latypov, Vitaly, Kanugula, Sreenivas, Butt, Amna, Melikishvili, Manana, Kraehenbuehl, Rolf, Fleck, Oliver, Marriott, Andrew, Watson, Amanda J., Verbeek, Barbara, McGown, Gail, Thorncroft, Mary, Santibanez-Koref, Mauro F., Millington, Christopher, Arvai, Andrew S., Kroeger, Matthew D., Peterson, Lisa A., Williams, David M., Fried, Michael G., Margison, Geoffrey P., Pegg, Anthony E., Tainer, John A.

“…Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy target O 6 -alkylguanine DNA-alkyltransferase (AGT) and…”
Get full text

Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6‐alkylguanine–DNA alkyltransferase by Crosbie, Philip A.J., McGown, Gail, Thorncroft, Mary R., O'Donnell, Paul N.S., Barber, Philip V., Lewis, Sarah J., Harrison, Kathryn L., Agius, Raymond M., Santibáñez‐Koref, Mauro F., Margison, Geoffrey P., Povey, Andrew C.

“…The association between lung cancer risk and 2 polymorphisms, rs12268840 and rs2308327 (codon K178R), in the DNA repair protein, O6‐alkylguanine–DNA…”
Get full text

Quantitative trait locus analysis reveals two intragenic sites that influence O super(6)-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells by Margison, Geoffrey P, Heighway, Jim, Pearson, Steven, McGown, Gail, Thorncroft, Mary R, Watson, Amanda J, Harrison, Kathryn L, Lewis, Sarah J, Rohde, Klaus, Barber, Philip V, O'Donnell, Paul, Povey, Andrew C, Santibanez-Koref, Mauro F

“…The repair of specific types of DNA alkylation damage by O super(6)-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the…”
Get full text

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O 6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1 by Plummer, E. Ruth, Middleton, Mark R., Jones, Christopher, Olsen, Anna, Hickson, Ian, McHugh, Peter, Margison, Geoffrey P., McGown, Gail, Thorncroft, Mary, Watson, Amanda J., Boddy, Alan V., Calvert, A. Hilary, Harris, Adrian L., Newell, David R., Curtin, Nicola J.

“…Purpose: Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is repaired by O6-alkylguanine alkyltransferase (ATase) and…”
Get full text

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O super(6)-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1 by Plummer, ERuth, Middleton, Mark R, Jones, Christopher, Olsen, Anna, Hickson, Ian, McHugh, Peter, Margison, Geoffrey P, McGown, Gail, Thorncroft, Mary, Watson, Amanda J, Boddy, Alan V, Calvert, AHilary, Harris, Adrian L, Newell, David R, Curtin, Nicola J

“…PURPOSE: Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is repaired by O super(6)-alkylguanine alkyltransferase…”
Get full text

Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells by Margison, Geoffrey P., Heighway, Jim, Pearson, Steven, McGown, Gail, Thorncroft, Mary R., Watson, Amanda J., Harrison, Kathryn L., Lewis, Sarah J., Rohde, Klaus, Barber, Philip V., O'Donnell, Paul, Povey, Andrew C., Santibáñez-Koref, Mauro F.

“…The repair of specific types of DNA alkylation damage by O6-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the carcinogenic and…”
Get full text