Search Results - "McGowan, Neil W A"

Generation of Functional Beta-Like Cells from Human Exocrine Pancreas by Lima, Maria J, Muir, Kenneth R, Docherty, Hilary M, McGowan, Neil W A, Forbes, Shareen, Heremans, Yves, Heimberg, Harry, Casey, John, Docherty, Kevin

“…Transcription factor mediated lineage reprogramming of human pancreatic exocrine tissue could conceivably provide an unlimited supply of islets for…”
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Safety profile of autologous macrophage therapy for liver cirrhosis by Moroni, Francesca, Dwyer, Benjamin J., Graham, Catriona, Pass, Chloe, Bailey, Laura, Ritchie, Lisa, Mitchell, Donna, Glover, Alison, Laurie, Audrey, Doig, Stuart, Hargreaves, Emily, Fraser, Alasdair R., Turner, Marc L., Campbell, John D. M., McGowan, Neil W. A., Barry, Jacqueline, Moore, Joanna K., Hayes, Peter C., Leeming, Diana J., Nielsen, Mette J., Musa, Kishwar, Fallowfield, Jonathan A., Forbes, Stuart J.

“…Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of…”
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Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity by Whitehouse, Caroline A., Waters, Sarah, Marchbank, Katie, Horner, Alan, McGowan, Neil W. A., Jovanovic, Jelena V., Xavier, Guilherme M., Kashima, Takeshi G., Cobourne, Martyn T., Richards, Gareth O., Sharpe, Paul T., Skerry, Tim M., Grigoriadis, Agamemnon E., Solomon, Ellen, Olson, Eric N.

“…The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a…”
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Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization by Forbes, Shareen, Bond, Andrew R, Thirlwell, Kayleigh L, Burgoyne, Paul, Samuel, Kay, Noble, June, Borthwick, Gary, Colligan, David, McGowan, Neil W A, Lewis, Philip Starkey, Fraser, Alasdair R, Mountford, Joanne C, Carter, Roderick N, Morton, Nicholas M, Turner, Marc L, Graham, Gerard J, Campbell, John D M

“…Islet transplantation is an efficacious therapy for type 1 diabetes; however, islets from multiple donor pancreata are required, and a gradual attrition in…”
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EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation by Cooper, Rachel S, Sutherland, Catherine, Smith, Linda M, Cowan, Graeme, Barnett, Mark, Mitchell, Donna, McLean, Colin, Imlach, Stuart, Hayes, Alan, Zahra, Sharon, Manchanayake, Champa, Vickers, Mark A, Graham, Gerry, McGowan, Neil W A, Turner, Marc L, Campbell, John D M, Fraser, Alasdair R

“…Adoptive immunotherapy with Epstein-Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant…”
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Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells by LIMA, Maria João, MUIR, Kenneth R, RAVASSARD, Philippe, HEIMBERG, Harry, CASEY, John, DOCHERTY, Kevin, DOCHERTY, Hilary M, DRUMMOND, Robert, MCGOWAN, Neil W. A, FORBES, Shareen, HEREMANS, Yves, HOUBRACKEN, Isabelle, ROSS, James A, FORBES, Stuart J

“…Because of the lack of tissue available for islet transplantation, new sources of β-cells have been sought for the treatment of type 1 diabetes. The aim of…”
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Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) by Brennan, Paul Noel, MacMillan, Mark, Manship, Thomas, Moroni, Francesca, Glover, Alison, Graham, Catriona, Semple, Scott, Morris, David M, Fraser, Alasdair R, Pass, Chloe, McGowan, Neil W A, Turner, Marc L, Lachlan, Neil, Dillon, John F, Campbell, John D M, Fallowfield, Jonathan Andrew, Forbes, Stuart J

“…IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications…”
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Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes by Forbes, Shareen, McGowan, Neil W. A., Duncan, Kirsty, Anderson, Debbie, Barclay, Janet, Mitchell, Donna, Docherty, Kevin, Turner, David, Campbell, John D. M., Casey, John J.

“…Aims/hypothesis Type 1 diabetes complicated by hypoglycaemia is prevalent in socioeconomically deprived populations. Islet transplantation is of proven…”
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Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture by Muir, Kenneth R, Lima, Maria João, Docherty, Hilary M, McGowan, Neil W A, Forbes, Shareen, Heremans, Yves, Forbes, Stuart J, Heimberg, Harry, Casey, John, Docherty, Kevin

“…A replenishable source of insulin-producing cells has the potential to cure type 1 diabetes. Attempts to culture and expand pancreatic β-cells in vitro have…”
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Binding Immunoglobulin Protein (BIP) Inhibits TNF‐α–Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model by Zaiss, Mario M., Hall, Christopher, McGowan, Neil W. A., Babb, Rebecca, Devlia, Vikesh, Lucas, Sébastien, Meghji, Sajeda, Henderson, Brian, Bozec, Aline, Schett, Georg, David, Jean‐Pierre, Panayi, Gabriel S., Grigoriadis, Agamemnon E., Corrigall, Valerie M.

“…Objective The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis and is recapitulated in the human tumor…”
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Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis by Fraser, Alasdair R., Pass, Chloe, Burgoyne, Paul, Atkinson, Anne, Bailey, Laura, Laurie, Audrey, W.A. McGowan, Neil, Hamid, Akib, Moore, Joanna K., Dwyer, Benjamin J., Turner, Marc L., Forbes, Stuart J., Campbell, John D.M.

“…Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration…”
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Pancreas-derived mesenchymal stromal cells share immune response-modulating and angiogenic potential with bone marrow mesenchymal stromal cells and can be grown to therapeutic scale under Good Manufacturing Practice conditions by Thirlwell, Kayleigh L., Colligan, David, Mountford, Joanne C., Samuel, Kay, Bailey, Laura, Cuesta-Gomez, Nerea, Hewit, Kay D., Kelly, Christopher J, West, Christopher C., McGowan, Neil W.A., Casey, John J., Graham, Gerard J., Turner, Marc L., Forbes, Shareen, Campbell, John D.M.

“…Mesenchymal stromal cells (MSCs) isolated from various tissues are under investigation as cellular therapeutics in a wide range of diseases. It is appreciated…”
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Good Manufacturing Practice (GMP) Translation of Advanced Cellular Therapeutics: Lessons for the Manufacture of Erythrocytes as Medicinal Products by McGowan, Neil W A, Campbell, John D M, Mountford, Joanne C

“…Blood transfusion is a mainstay of modern medical practice. In many parts of the world the use of this life-saving therapy is hampered by issues of supply and…”
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Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study by Moore, Joanna K, Mackinnon, Alison C, Wojtacha, Dvina, Pope, Caroline, Fraser, Alasdair R, Burgoyne, Paul, Bailey, Laura, Pass, Chloe, Atkinson, Anne, Mcgowan, Neil W.A, Manson, Lynn, Turner, Mark L, Campbell, John D.M, Forbes, Stuart J

“…Abstract Background aims Macrophages have complex roles in the liver. The aim of this study was to compare profiles of human monocyte-derived macrophages…”
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Allogeneic Ex Vivo Expanded Corneal Epithelial Stem Cell Transplantation: A Randomized Controlled Clinical Trial by Campbell, John D.M., Ahmad, Sajjad, Agrawal, Ashish, Bienek, Carol, Atkinson, Anne, Mcgowan, Neil W.A., Kaye, Stephen, Mantry, Sanjay, Ramaesh, Kanna, Glover, Alison, Pelly, Jane, MacRury, Coral, MacDonald, Margaret, Hargreaves, Emily, Barry, Jacqueline, Drain, John, Cuthbertson, Bruce, Nerurkar, Louis, Downing, Ian, Fraser, Alasdair R., Turner, Marc L., Dhillon, Baljean

“…Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous…”
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Cytokine-Activated Endothelium Recruits Osteoclast Precursors by McGowan, Neil W. A, Walker, Emily J, Macpherson, Heather, Ralston, Stuart H, Helfrich, Miep H

“…Osteoclast precursors reach sites of osteoclast formation and remodelling via the vasculature and are therefore destined to encounter endothelium before…”
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A Mutation Affecting the Latency-Associated Peptide of TGFβ1 in Camurati-Engelmann Disease Enhances Osteoclast Formation in Vitro by McGowan, Neil W. A., MacPherson, Heather, Janssens, Katrien, Van Hul, Wim, Frith, Julie C., Fraser, William D., Ralston, Stuart H., Helfrich, Miep H.

“…Camurati-Engelmann disease (CED) is a rare autosomal dominant disorder characterized by bone pain and osteosclerosis affecting the diaphysis of long bones. CED…”
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Islet Activity and Outcomes in the United Kingdom by Mumford, Lisa L, Shaw, James AM, Johnson, Paul, Jones, Gareth, Parrott, Neil, Rutter, Martin K, Amiel, Stephanie, Smith, Richard M, McGowan, Neil WA, Hughes, Stephen, Huang, Guo Cai, Casey, John

“…On 1 April 2008 an integrated national islet transplant programme was commissioned in the United Kingdom (UK) for treatment of recurrent life-threatening…”
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Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing [beta]-like cells.(ORIGINAL ARTICLE) by Lima, Maria Joao, Muir, Kenneth R, Docherty, Hilary M, Drummond, Robert, McGowan, Neil W.A, Forbes, Shareen, Heremans, Yves, Houbracken, Isabelle, Ross, James A, Forbes, Stuart J, Ravassard, Philippe, Heimberg, Harry, Casey, John, Docherty, Kevin

“…Because of the lack of tissue available for islet transplantation, new sources of [beta]-cells have been sought for the treatment of type 1 diabetes. The aim…”
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A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro by McGowan, Neil W A, MacPherson, Heather, Janssens, Katrien, Van Hul, Wim, Frith, Julie C, Fraser, William D, Ralston, Stuart H, Helfrich, Miep H

“…Camurati-Engelmann disease (CED) is a rare autosomal dominant disorder characterized by bone pain and osteosclerosis affecting the diaphysis of long bones. CED…”
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