Search Results - "McGovern, Kathryn"

GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii by David, Clément N, Frias, Elma S, Szu, Jenny I, Vieira, Philip A, Hubbard, Jacqueline A, Lovelace, Jonathan, Michael, Marena, Worth, Danielle, McGovern, Kathryn E, Ethell, Iryna M, Stanley, B Glenn, Korzus, Edward, Fiacco, Todd A, Binder, Devin K, Wilson, Emma H

“…The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about the effects of lifelong brain…”
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Amyloid beta’s antimicrobial properties protect elderly mice from succumbing to infection with the neurotropic parasite Toxoplasma gondii by McGovern, Kathryn E., Koshy, Anita A

“…Background Data suggest that amyloid beta (Aβ) is a major initiator of Alzheimer's disease (AD) and a highly conserved anti‐microbial peptide. Although Aβ…”
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Global landscape of HIV–human protein complexes by Jäger, Stefanie, Cimermancic, Peter, Gulbahce, Natali, Johnson, Jeffrey R., McGovern, Kathryn E., Clarke, Starlynn C., Shales, Michael, Mercenne, Gaelle, Pache, Lars, Li, Kathy, Hernandez, Hilda, Jang, Gwendolyn M., Roth, Shoshannah L., Akiva, Eyal, Marlett, John, Stephens, Melanie, D’Orso, Iván, Fernandes, Jason, Fahey, Marie, Mahon, Cathal, O’Donoghue, Anthony J., Todorovic, Aleksandar, Morris, John H., Maltby, David A., Alber, Tom, Cagney, Gerard, Bushman, Frederic D., Young, John A., Chanda, Sumit K., Sundquist, Wesley I., Kortemme, Tanja, Hernandez, Ryan D., Craik, Charles S., Burlingame, Alma, Sali, Andrej, Frankel, Alan D., Krogan, Nevan J.

“…Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human…”
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Comparative 3D genome organization in apicomplexan parasites by Bunnik, Evelien M., Venkat, Aarthi, Shao, Jianlin, McGovern, Kathryn E., Batugedara, Gayani, Worth, Danielle, Prudhomme, Jacques, Lapp, Stacey A., Andolina, Chiara, Ross, Leila S., Lawres, Lauren, Brady, Declan, Sinnis, Photini, Nosten, Francois, Fidock, David A., Wilson, Emma H., Tewari, Rita, Galinski, Mary R., Mamoun, Choukri Ben, Ay, Ferhat, Le Roch, Karine G.

“…The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression. In the…”
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Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory by McGovern, Kathryn E., Cabral, Carla M., Morrison, Helena W., Koshy, Anita A.

“…Persistent inflammation has been identified as a contributor to aging-related neurodegenerative disorders such as Alzheimer’s disease. Normal aging, in the…”
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SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection by McGovern, Kathryn E., Nance, J. Philip, David, Clément N., Harrison, Reed E. S., Noor, Shahani, Worth, Danielle, Landrith, Tyler A., Obenaus, Andre, Carson, Monica J., Morikis, Dimitrios, Wilson, Emma H.

“…Central nervous system (CNS) injury and infection can result in profound tissue remodeling in the brain, the mechanism and purpose of which is poorly…”
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The aging of the immune system and its implications for transplantation by McGovern, Kathryn E., Sonar, Sandip A., Watanabe, Makiko, Coplen, Christopher P., Bradshaw, Christine M., Nikolich, Janko Ž.

“…By the last third of life, most mammals, including humans, exhibit a decline in immune cell numbers, immune organ structure, and immune defense of the…”
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Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool by Cabral, Carla M., McGovern, Kathryn E., MacDonald, Wes R., Franco, Jenna, Koshy, Anita A.

“…Genetic and pathologic data suggest that amyloid beta (Aβ), produced by processing of the amyloid precursor protein, is a major initiator of Alzheimer’s…”
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Dark side illuminated: imaging of Toxoplasma gondii through the decades by McGovern, Kathryn E, Wilson, Emma H

“…In the more than 100 years since its discovery, our knowledge of Toxoplasma biology has improved enormously. The evolution of molecular biology, immunology and…”
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An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice by Ghosh, Debopam, Wikenheiser, Daniel J, Kennedy, Brian, McGovern, Kathryn E, Stuart, Johnasha D, Wilson, Emma H, Stumhofer, Jason S

“…Hematopoietic stem and progenitor cells (HSPCs) function to replenish the immune cell repertoire under steady-state conditions and in response to inflammation…”
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Molecular mechanisms underlying beta-arrestin-dependent chemotaxis and actin-cytoskeletal reorganization by McGovern, Kathryn W, DeFea, Kathryn A

“…β-Arrestins play a crucial role in cell migration downstream of multiple G-protein-coupled receptors (GPCRs) through multiple mechanisms. There is considerable…”
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Effects of anthropogenic noise on endocrine and reproductive function in White's treefrog, Litoria caerulea by Kaiser, Kristine, Devito, Julia, Jones, Caitlin G., Marentes, Adam, Perez, Rachel, Umeh, Lisa, Weickum, Regina M., McGovern, Kathryn E., Wilson, Emma H., Saltzman, Wendy

“…Urbanization brings the introduction of roads and anthropogenic noise. Noise has negative health outcomes across vertebrates. White's treefrogs ( Litoria…”
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Reproductive and immune effects of chronic corticosterone treatment in male White’s treefrogs, Litoria caerulea by Kaiser, Kristine, Devito, Julia, Jones, Caitlin G., Marentes, Adam, Perez, Rachel, Umeh, Lisa, Weickum, Regina M., McGovern, Kathryn E., Wilson, Emma H., Saltzman, Wendy

“…Long-term elevation of glucocorticoid hormones associated with chronic stress may be detrimental. Chronic treatment of White's treefrogs with exogenous…”
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Antitumor Activity of a Polypyridyl Chelating Ligand: In Vitro and In Vivo Inhibition of Glioma by David, Clément N., Frias, Elma S., Elix, Catherine C., McGovern, Kathryn E., Walker, Ameae M., Eichler, Jack F., Wilson, Emma H.

“…Glioblastoma multiforme is an extremely aggressive and invasive form of central nervous system tumor commonly treated with the chemotherapeutic drug…”
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Probing amyloid beta dynamics in the brain using distinct strains of the neurotropic parasite Toxoplasma gondii: Molecular and cell biology/APP/Abeta/amyloid by McGovern, Kathryn E., Cabral, Carla M., Koshy, Anita A.

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Probing amyloid beta dynamics in the brain using distinct strains of the neurotropic parasite Toxoplasma gondii by McGovern, Kathryn E., Cabral, Carla M., Koshy, Anita A.

“…Background Data suggest that amyloid beta (Aβ), produced by processing of the amyloid precursor protein, is a major initiator of Alzheimer's disease (AD) and a…”
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A cynomolgus monkey E. coli urinary tract infection model confirms efficacy of new FimH vaccine candidates by Chorro, Laurent, Ciolino, Tara, Torres, Caresse Lynn, Illenberger, Arthur, Aglione, JohnPaul, Corts, Paula, Lypowy, Jacqueline, Ponce, Christopher, La Porte, Annalena, Burt, Deborah, Volberg, Gretchen L, Ramaiah, Lila, McGovern, Kathryn, Hu, Jianfang, Anderson, Annaliesa S, Silmon de Monerri, Natalie C, Kanevsky, Isis, Donald, Robert G K

“…The increase in urinary tract infections (UTI) caused by antibiotic-resistant requires the development of new therapeutic agents and prophylactic vaccines. To…”
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Plus Disease in Retinopathy of Prematurity: A Continuous Spectrum of Vascular Abnormality as a Basis of Diagnostic Variability by Campbell, J Peter, Kalpathy-Cramer, Jayashree, Erdogmus, Deniz, Tian, Peng, Kedarisetti, Dharanish, Moleta, Chace, Reynolds, James D, Hutcheson, Kelly, Shapiro, Michael J, Repka, Michael X, Ferrone, Philip, Drenser, Kimberly, Horowitz, Jason, Sonmez, Kemal, Swan, Ryan, Ostmo, Susan, Jonas, Karyn E, Chan, R V Paul, Chiang, Michael F

“…To identify patterns of interexpert discrepancy in plus disease diagnosis in retinopathy of prematurity (ROP). We developed 2 datasets of clinical images as…”
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Plus Disease in Retinopathy of Prematurity: Improving Diagnosis by Ranking Disease Severity and Using Quantitative Image Analysis by Kalpathy-Cramer, Jayashree, Campbell, J Peter, Erdogmus, Deniz, Tian, Peng, Kedarisetti, Dharanish, Moleta, Chace, Reynolds, James D, Hutcheson, Kelly, Shapiro, Michael J, Repka, Michael X, Ferrone, Philip, Drenser, Kimberly, Horowitz, Jason, Sonmez, Kemal, Swan, Ryan, Ostmo, Susan, Jonas, Karyn E, Chan, R V Paul, Chiang, Michael F

“…To determine expert agreement on relative retinopathy of prematurity (ROP) disease severity and whether computer-based image analysis can model relative…”
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Association of Biomarker-Based Artificial Intelligence With Risk of Racial Bias in Retinal Images by Coyner, Aaron S, Singh, Praveer, Brown, James M, Ostmo, Susan, Chan, R V Paul, Chiang, Michael F, Kalpathy-Cramer, Jayashree, Campbell, J Peter

“…Although race is a social construct, it is associated with variations in skin and retinal pigmentation. Image-based medical artificial intelligence (AI)…”
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