Search Results - "McGovern, Josh"

Computed tomography‐defined low skeletal muscle index and density in cancer patients: observations from a systematic review by McGovern, Josh, Dolan, Ross D., Horgan, Paul G., Laird, Barry J., McMillan, Donald C.

“…Background Computed tomography (CT) analysis of body composition has garnered interest as a potential prognostic tool in those with cancer. A range of…”
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Comment on “A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer” by Zhang et al by McGovern, Josh, McMillan, Donald C.

“…[...]NLR contributed more prognostic value in patients without weight loss compared with the prognostic value of weight loss in patients who were not…”
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CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer by Golder, Allan M., Ferguson, Michael, McMillan, Paul, Mansouri, David, Horgan, Paul G., Roxburgh, Campbell S., Dolan, Ross D., McGovern, Josh, McMillan, Donald C.

“…Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory…”
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CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study by Bradley, Nicholas A, McGovern, Josh, Dolan, Ross D, Golder, Allan M, Roxburgh, Campbell S D, Guthrie, Graeme J K, McMillan, Donald C

“…Low skeletal muscle mass and density, as assessed by CT-body composition (CT-BC), are recognised to have prognostic value in non-cancer and cancer patients…”
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The relationship between the modified frailty index score (mFI-5), malnutrition, body composition, systemic inflammation and short-term clinical outcomes in patients undergoing surgery for colorectal cancer by McGovern, Josh, Grayston, Alexander, Coates, Dominic, Leadbitter, Stephen, Hounat, Adam, Horgan, Paul G, Dolan, Ross D, McMillan, Donald C

“…While the current literature suggests an association with frailty and clinical outcomes in patients undergoing surgery for colorectal cancer (CRC), the basis…”
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The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19 by McGovern, Josh, Al-Azzawi, Yassir, Kemp, Olivia, Moffitt, Peter, Richards, Conor, Dolan, Ross D, Laird, Barry J, McMillan, Donald C, Maguire, Donogh

“…Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality…”
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The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review by McGovern, Josh, Dolan, Ross D, Horgan, Paul G, Laird, Barry J, McMillan, Donald C

“…Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed…”
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The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer by McGovern, Josh, Leadbitter, Stephen, Miller, Gillian, Hounat, Adam, Kamande, Irvine, Dolan, Ross D., Horgan, Paul G., Chang, David K., Jamieson, Nigel B., McMillan, Donald C.

“…High vagal nerve activity, reliability measured by HRV, is considered protective in cancer, reducing oxidative stress, inflammation and opposing sympathetic…”
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The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19 by McGovern, Josh, Wadsworth, John, Catchpole, Anthony, Richards, Conor, McMillan, Donald C, Kelliher, Tadhg, Goodall, Emma, Murray, Ellie, Melaugh, Terry, McPhillips, Shannon, Brice, Kathryn, Barbour, Katie, Robinson, Sophie, Moffitt, Peter, Kemp, Olivia, Talwar, Dinesh, Maguire, Donogh

“…Micronutrients have been associated with disease severity and poorer clinical outcomes in patients with COVID-19. However, there is a paucity of studies…”
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The relationship between clinicopathological variables, systemic inflammation, and CT‐derived body composition with survival in patients with advanced non‐small cell lung cancer receiving nivolumab as a second‐line treatment by Saeed, Randa, McGovern, Josh, Bench, Hugo, Dolan, Ross D., McMillan, Donald C., Cascales, Almudena

“…Background Second‐line immunotherapy is currently recognized to help only a subset of patients with advanced forms of non‐small cell lung cancer (NSCLC). The…”
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The prevalence and prognostic value of systemic inflammation in good performance status patients with advanced, inoperable non‐small cell lung cancer receiving palliative radiotherapy: Comparison of composite ratios and cumulative scores by McGovern, Josh, O'Rourke, Fraser, Will, Sarah, Nguyen, Hanh Thi Ngoc, Cranfield, Elise, Maseland, Charlotte, MacLeod, Nicholas, Maclay, John D., Laird, Barry J., Dolan, Ross D., McMillan, Donald C.

“…Introduction The present study sought to examine the relationships between systemic inflammatory composite ratios/cumulative scores, magnitude of systemic…”
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The Relationship between Liver Volume, Clinicopathological Characteristics and Survival in Patients Undergoing Resection with Curative Intent for Non-Metastatic Colonic Cancer by McGovern, Josh, Mackay, Charles, Freireich, Rhiannon, Golder, Allan M, Dolan, Ross D, Horgan, Paul G, Holroyd, David, Jamieson, Nigel B, McMillan, Donald C

“…The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between…”
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Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series by Yule, Michael S., Thompson, Joshua, Leesahatsawat, Khachonphat, Sousa, Mariana S., Anker, Stefan D., Arends, Jann, Balstad, Trude R., Brown, Leo R., Bye, Asta, Dajani, Olav, Fallon, Marie, Hjermstad, Marianne J., Jakobsen, Gunnhild, McDonald, James, McGovern, Josh, Roeland, Eric J., Sayers, Judith, Skipworth, Richard J.E., Ottestad, Inger O., Philips, Iain, Simpson, Melanie R., Solheim, Tora S., Vagnildhaug, Ola Magne, McMillan, Donald, Laird, Barry J.A., Dolan, Ross D.

“…Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered…”
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Cancer cachexia: a nutritional or a systemic inflammatory syndrome? by McGovern, Josh, Dolan, Ross D., Skipworth, Richard J., Laird, Barry J., McMillan, Donald C.

“…Cancer cachexia has long been perceived as a nutritional syndrome. However, nutritional interventions have continued to be ineffective. With the recent…”
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RE: Exercise and Nutrition to Improve Cancer Treatment-Related outcomes (ENICTO) by McGovern, Josh, Dolan, Ross D, Skipworth, Richard J E, Laird, Barry J A, McMillan, Donald C

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Relation Between Body Composition, Systemic Inflammatory Response, and Clinical Outcomes in Patients Admitted to an Urban Teaching Hospital with COVID-19 by McGovern, Josh, Dolan, Ross, Richards, Conor, Laird, Barry J, McMillan, Donald C, Maguire, Donogh

“…COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. The aim of the…”
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The relationship between pre-operative anti-depressant use, malnutrition, co-morbidity, BMI, disease stage, systemic inflammation and survival in patients undergoing surgery for colorectal cancer by Kamande, Irvine W., Hounat, Adam, Leadbitter, Stephen, Dolan, Ross, Roxburgh, Campbell, Horgan, Paul, McGovern, Josh, McMillan, Donald

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The relationship between CT-derived sarcopenia, systemic inflammation, physical function and survival in patients with advanced cancer by McGovern, Josh, Dolan, Ross D, Simmons, Claribel, Laird, Barry, Fallon, Marie T., Power, Derek Gerard, Daly, Louise, Ryan, Aoife M, Horgan, Paul G., McMillan, Donald C.

“…804 Background: The CT-derived sarcopenia score (CT-SS) is thought to capture the nutritional and functional reserve of the cancer patient. However, it is…”
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The relationship between frailty, malnutrition, BMI, disease stage, systemic inflammation and survival in patients undergoing surgery for colorectal cancer by Grayston, Alexander, Leadbitter, Stephen, Coates, Dominic, Hounat, Adam, Kamande, Irvine W., Dolan, Ross, Roxburgh, Campbell, McGovern, Josh, Horgan, Paul, McMillan, Donald

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The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis by Thompson, Joshua J., McGovern, Josh, Roxburgh, Campbell S.D., Edwards, Joanne, Dolan, Ross D., McMillan, Donald C.

“…Cancer cachexia is a clinical condition characterized by recognizable “sickness behaviors” accompanied by loss of lean body tissue. The Global Leadership on…”
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