Search Results - "McGivney, Gavin R."

Discrepancies in indel software resolution with somatic CRISPR/Cas9 tumorigenesis models by Brockman, Qierra R., Scherer, Amanda, McGivney, Gavin R., Gutierrez, Wade R., Rytlewski, Jeffrey, Sheehan, Alexa, Warrier, Akshaya, Laverty, Emily A., Roughton, Grace, Carnevale, Nina C., Knepper-Adrian, Vickie, Dodd, Rebecca D.

“…CRISPR/Cas9 gene editing has evolved from a simple laboratory tool to a powerful method of in vivo genomic engineering. As the applications of CRISPR/Cas9…”
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Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models by Gutierrez, Wade R., Scherer, Amanda, McGivney, Gavin R., Brockman, Qierra R., Knepper-Adrian, Vickie, Laverty, Emily A., Roughton, Grace A., Dodd, Rebecca D.

“…Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered…”
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Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma by Gutierrez, Wade R, Rytlewski, Jeffrey D, Scherer, Amanda, Roughton, Grace A, Carnevale, Nina C, Vyas, Krisha Y, McGivney, Gavin R, Brockman, Qierra R, Knepper-Adrian, Vickie, Dodd, Rebecca D

“…Rhabdomyosarcoma (RMS) is an aggressive form of cancer that accounts for half of all pediatric soft tissue sarcomas. Little progress has been made in improving…”
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PRC2 loss drives MPNST metastasis and matrix remodeling by Brockman, Qierra R, Scherer, Amanda, McGivney, Gavin R, Gutierrez, Wade R, Voigt, Andrew P, Isaacson, Alexandra L, Laverty, Emily A, Roughton, Grace, Knepper-Adrian, Vickie, Darbro, Benjamin, Tanas, Munir R, Stipp, Christopher S, Dodd, Rebecca D

“…The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent…”
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Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism by Gutierrez, Wade R, Scherer, Amanda, Rytlewski, Jeffrey D, Laverty, Emily A, Sheehan, Alexa P, McGivney, Gavin R, Brockman, Qierra R, Knepper-Adrian, Vickie, Roughton, Grace A, Quelle, Dawn E, Gordon, David J, Monga, Varun, Dodd, Rebecca D

“…The DNA methyltransferase inhibitor decitabine has classically been used to reactivate silenced genes and as a pretreatment for anticancer therapies. In a…”
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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression by Kohlmeyer, Jordan L, Lingo, Joshua J, Kaemmer, Courtney A, Scherer, Amanda, Warrier, Akshaya, Voigt, Ellen, Raygoza Garay, Juan A, McGivney, Gavin R, Brockman, Qierra R, Tang, Amy, Calizo, Ana, Pollard, Kai, Zhang, Xiaochun, Hirbe, Angela C, Pratilas, Christine A, Leidinger, Mariah, Breheny, Patrick, Chimenti, Michael S, Sieren, Jessica C, Monga, Varun, Tanas, Munir R, Meyerholz, David K, Darbro, Benjamin W, Dodd, Rebecca D, Quelle, Dawn E

“…Malignant peripheral nerve sheath tumors (MPNST) are lethal, Ras-driven sarcomas that lack effective therapies. We investigated effects of targeting…”
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Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten -deleted Mouse Models of Sarcoma by Dodd, Rebecca D, Scherer, Amanda, Huang, Wesley, McGivney, Gavin R, Gutierrez, Wade R, Laverty, Emily A, Ashcraft, Kathleen A, Stephens, Victoria R, Yousefpour, Parisa, Saha, Soumen, Knepper-Adrian, Vickie, Floyd, Warren, Chen, Mark, Ma, Yan, Mastria, Eric M, Cardona, Diana M, Eward, William C, Chilkoti, Ashutosh, Kirsch, David G

“…Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a…”
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Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs by Scherer, Amanda, Stephens, Victoria R, McGivney, Gavin R, Gutierrez, Wade R, Laverty, Emily A, Knepper-Adrian, Vickie, Dodd, Rebecca D

“…The tumor microenvironment plays important roles in cancer biology, but genetic backgrounds of mouse models can complicate interpretation of tumor phenotypes…”
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Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo by Kohlmeyer, Jordan L, Kaemmer, Courtney A, Lingo, Joshua J, Voigt, Ellen, Leidinger, Mariah R, McGivney, Gavin R, Scherer, Amanda, Koppenhafer, Stacia L, Gordon, David J, Breheny, Patrick, Meyerholz, David K, Tanas, Munir R, Dodd, Rebecca D, Quelle, Dawn E

“…Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with complex molecular and genetic alterations. Powerful tumor…”
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Abstract A024: PRC2 loss drives MPNST metastasis and matrix remodeling by Brockman, Qierra R., Scherer, Amanda, McGivney, Gavin R., Gutierrez, Wade R., Voigt, Andrew, Isaacson, Alexandra, Laverty, Emily A., Roughton, Grace, Knepper-Adrian, Vickie, Darbro, Benjamin, Tanas, Munir R., Stipp, Christopher, Dodd, Rebecca D.

“…Epigenetic reprogramming alters gene transcription in response to different cellular cues and can occur at both the DNA level as well as histone…”
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