A Nosocomial Outbreak of Fluoroquinolone-Resistant Salmonella Infection

The outbreak was nosocomial and involved person-to-person transmission. Each year an estimated 1.4 million salmonella infections occur in the United States. 1 Most occur as a result of eating contaminated food, 2 particularly foods of animal origin. Person-to-person and nosocomial transmission have...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 344; no. 21; pp. 1572 - 1579
Main Authors:	Olsen, Sonja J, DeBess, Emilio E, McGivern, Teresa E, Marano, Nina, Eby, Tom, Mauvais, Steve, Balan, Vijay K, Zirnstein, Gerald, Cieslak, Paul R, Angulo, Frederick J
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 24-05-2001
Subjects:	Aged Aged, 80 and over Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial agents Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Case-Control Studies Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - transmission Disease Outbreaks Disease Transmission, Infectious Drug Resistance, Microbial Drug Utilization - statistics & numerical data Electrophoresis, Gel, Pulsed-Field Female Fluoroquinolones Hospitals Human bacterial diseases Humans Infections Infectious diseases Male Medical sciences Microbial Sensitivity Tests Middle Aged Nursing Nursing Homes Oregon - epidemiology Patients Risk Factors Salmonella Salmonella enterica Salmonella enterica - classification Salmonella enterica - drug effects Salmonella enterica - isolation & purification Salmonella Infections - epidemiology Salmonella Infections - microbiology Salmonella Infections - transmission United States North America America Oregon New York United States > US Philippines Human Nosocomial infection Case control study Epidemiology Infection Antibiotic Chemotherapy Fluoroquinolone derivatives Outbreak Risk factor Bacteriosis Digestive diseases Salmonellosis Negative therapeutic reaction
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Summary:	The outbreak was nosocomial and involved person-to-person transmission. Each year an estimated 1.4 million salmonella infections occur in the United States. 1 Most occur as a result of eating contaminated food, 2 particularly foods of animal origin. Person-to-person and nosocomial transmission have become rare in the United States 3 but remain problems in developing countries. 4 , 5 Antimicrobial agents are not essential for the treatment of most salmonella infections, but they can be lifesaving in cases of severe infection. 6 Fluoroquinolones such as ciprofloxacin are commonly used for adult patients with salmonella infections and for the treatment of acute gastroenteritis. The use of ampicillin, chloramphenicol, and trimethoprim–sulfamethoxazole is limited because of increasing antimicrobial . . .
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM200105243442102