Search Results - "McGivern, Jered V"

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy by Sareen, Dhruv, Ebert, Allison D, Heins, Brittany M, McGivern, Jered V, Ornelas, Loren, Svendsen, Clive N

“…Spinal muscular atrophy (SMA) is a genetic disorder caused by a deletion of the survival motor neuron 1 gene leading to motor neuron loss, muscle atrophy,…”
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Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production by McGivern, Jered V., Patitucci, Teresa N., Nord, Joshua A., Barabas, Marie-Elizabeth A., Stucky, Cheryl L., Ebert, Allison D.

“…Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival motor neuron 1 (SMN1) gene that leads to loss of motor neurons in…”
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Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments by McGivern, Jered V., Ebert, Allison D.

“…In order for the pharmaceutical industry to maintain a constant flow of novel drugs and therapeutics into the clinic, compounds must be thoroughly validated…”
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Derivation of Myogenic Progenitors Directly From Human Pluripotent Stem Cells Using a Sphere‐Based Culture by Hosoyama, Tohru, McGivern, Jered V., Van Dyke, Jonathan M., Ebert, Allison D., Suzuki, Masatoshi

“…The authors present a novel protocol for deriving myogenic progenitors from human embryonic stem cells and induced pluripotent stem cells using free‐floating…”
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Structural basis for RNA recognition by a type II poly(A)-binding protein by Song, Jikui, McGivern, Jered V, Nichols, Karl W, Markley, John L, Sheets, Michael D

“…We identified a functional domain (XlePABP2-TRP) of Xenopus laevis embryonic type II poly(A)-binding protein (XlePABP2). The NMR structure of XlePABP2-TRP…”
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Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy by Miller, Nimrod, Xu, Zhaofa, Quinlan, Katharina A, Ji, Amy, McGivern, Jered V, Feng, Zhihua, Shi, Han, Ko, Chien-Ping, Tsai, Li-Huei, Heckman, Charles J, Ebert, Allison D, Ma, Yongchao C

“…Spinal muscular atrophy (SMA), the top genetic cause of infant mortality, is characterized by motor neuron degeneration. Mechanisms underlying SMA pathogenesis…”
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Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy by Afzal, Muhammad Z, Reiter, Melanie, Gastonguay, Courtney, McGivern, Jered V, Guan, Xuan, Ge, Zhi-Dong, Mack, David L, Childers, Martin K, Ebert, Allison D, Strande, Jennifer L

“…Dystrophin-deficient cardiomyopathy is a growing clinical problem without targeted treatments. We investigated whether nicorandil promotes cardioprotection in…”
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Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation by Bigley, Tarin M., McGivern, Jered V., Ebert, Allison D., Terhune, Scott S.

“…Human cytomegalovirus (HCMV) is the leading cause of congenital infections. Symptomatic newborns present with a range of sequelae including disorders of the…”
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EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs by Ebert, Allison D, Shelley, Brandon C, Hurley, Amanda M, Onorati, Marco, Castiglioni, Valentina, Patitucci, Teresa N, Svendsen, Soshana P, Mattis, Virginia B, McGivern, Jered V, Schwab, Andrew J, Sareen, Dhruv, Kim, Ho Won, Cattaneo, Elena, Svendsen, Clive N

“…We have developed a simple method to generate and expand multipotent, self-renewing pre-rosette neural stem cells from both human embryonic stem cells (hESCs)…”
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Toward defining the phosphoproteome of Xenopus laevis embryos by McGivern, Jered V., Swaney, Danielle L., Coon, Joshua J., Sheets, Michael D.

“…Phosphorylation is universally used for controlling protein function, but knowledge of the phosphoproteome in vertebrate embryos has been limited. However,…”
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Post transcriptional regulation of early Xenopus laevis development by McGivern, Jered V

“…Vertebrate development begins with a single cell, and transforms it into a multi-cellular organism with a defined body axis. Although much of this information…”
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