Search Results - "McGirr, Crystal"

Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization by Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard, Lévesque, Jean-Pierre

“…We show that pro-inflammatory oncostatin M (OSM) is an important regulator of hematopoietic stem cell (HSC) niches in the bone marrow (BM). Treatment of…”
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Bacterial Lipopolysaccharides Suppress Erythroblastic Islands and Erythropoiesis in the Bone Marrow in an Extrinsic and G- CSF-, IL-1-, and TNF-Independent Manner by Bisht, Kavita, Tay, Joshua, Wellburn, Rebecca N, McGirr, Crystal, Fleming, Whitney, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G, Levesque, Jean-Pierre

“…Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin,…”
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An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer by Akhir, Fazrena Nadia Md, Noor, Mohd Hezmee Mohd, Leong, Keith Weng Kit, Nabizadeh, Jamileh A, Manthey, Helga D, Sonderegger, Stefan E, Fung, Jenny Nga Ting, McGirr, Crystal E, Shiels, Ian A, Mills, Paul C, Woodruff, Trent M, Rolfe, Barbara E

“…The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine…”
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Macrophage Involvement in the Response of Acute Myeloid Leukaemia to Chemotherapy by Keech, Thomas, McGirr, Crystal, Winkler, Ingrid G, Levesque, Jean-Pierre

“…Acute myeloid leukemia (AML) is a clonally heterogeneous neoplasm with poor survival rates. Although chemotherapy often leads to clinical remission, the…”
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Oncostatin M Is a Novel Niche Factor That Restrains Hematopoietic Stem Cell Mobilization in Response to G-CSF and CXCR4 Antagonist Plerixafor by Bisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller, Winkler, Ingrid G, Levesque, Jean-Pierre

“…Granulocyte colony-stimulating factor (G-CSF) and the CXCR4 chemokine receptor antagonist Plerixafor are used to mobilize hematopoietic stem and progenitor…”
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Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow by Tay, Joshua, Bisht, Kavita, McGirr, Crystal, Millard, Susan M., Pettit, Allison R., Winkler, Ingrid G., Levesque, Jean-Pierre

“…•Nine-channel imaging flow cytometry can quantitate EBIs.•Most cell aggregates co-expressing macrophage and erythroblast markers are not EBIs.•EBI central…”
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Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes by Pattabiraman, Diwakar R., McGirr, Crystal, Shakhbazov, Konstantin, Barbier, Valerie, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Ding, Jianmin, Grimmond, Sean M., Papathanasiou, Peter, Alexander, Warren S., Perkins, Andrew C., Levesque, Jean-Pierre, Winkler, Ingrid G., Gonda, Thomas J.

“…The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a…”
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ERYTHROPOIESIS SUPPRESSION BY BACTERIAL LIPOSACCHARIDES IS EXTRINSICALLY MEDIATED INDEPENDENTLY OF G-CSF by Bisht, Kavita, Tay, Joshua, Jacobsen, Rebecca, McGirr, Crystal, Fleming, Whitney, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid, Levesque, Jean-Pierre

“…The central macrophage (MΦ) in erythroblastic islands (EI) is critical to erythropoiesis by providing iron and growth factors, and mediating enucleation of the…”
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3002 – ONCOSTATIN M IS A NOVEL NICHE FACTOR THAT RESTRAINS HAEMATOPOIETIC STEM CELL MOBILISATION IN RESPONSE TO G-CSF AND CXCR4 ANTAGONIST PLERIXAFOR by Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie, Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie, Müller-Newen, Gerhard, Winkler, Ingrid, Bönig, Halvard, Levesque, Jean-Pierre

“…Here we show that the pro-inflammatory cytokine oncostatin M (OSM) is an important regulator of haematopoietic stem cell (HSC) niches in the bone marrow (BM)…”
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MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo by Ye, Ping, Zhao, Liang, McGirr, Crystal, Gonda, Thomas J

“…Highlights • Inducible shRNA-mediated MYB knockdown suppresses growth of U937 leukaemia cells in vitro and in vivo. • MYB knockdown sensitises U937 cells to…”
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Suppression of Medullar Erythropoiesis in Response to Bacterial Lipopolysaccharides (LPS) Involves Two Distinct TLR4-Dependent Mechanisms with Contrasted Requirements for G-CSF Receptors by Bisht, Kavita, Jacobsen, Rebecca, Nowlan, Bianca, McGirr, Crystal, Brunck, Marion, Keech, Thomas, Winkler, Ingrid G, Levesque, Jean-Pierre

“…Erythropoiesis is a highly controlled process partly regulated in erythroblastic islands by the central erythroblastic island macrophage (EI MΦ) which provides…”
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MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589in vitroandin vivo by Ye, Ping, Zhao, Liang, McGirr, Crystal, Gonda, Thomas J

“…The effect of combiningMYBsuppression with the histone deacetylase inhibitor LBH589 was studied in human myeloid leukemia cell lines.MYBknockdown inhibited…”
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Hematopoietic stem cell mobilization and erythropoiesis suppression in response to lipopolysaccharides involve two distinct TLR4-depedent mechanisms with different requirement for G-CSF receptors by Bisht, Kavita, Jacobsen, Rebecca, Brunck, Marion, Keech, Thomas, McGirr, Crystal, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid, Levesque, Jean-Pierre

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Autophagy prevents graft failure during murine graft-versus-host disease by Lineburg, Katie E., Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laetitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W., Hill, Geoffrey R., Lévesque, Jean-Pierre, MacDonald, Kelli P. A.

“…•HSC increase autophagy in response to mitochondrial stress and cytokine stimulation with IL-1β and TNF identified as key inducers.•HSC and HPC require…”
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HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR by Bisht, Kavita, Brunck, Marion E., Matsumoto, Taichi, McGirr, Crystal, Nowlan, Bianca, Fleming, Whitney, Keech, Thomas, Magor, Graham, Perkins, Andrew C., Davies, Julie, Walkinshaw, Gail, Flippin, Lee, Winkler, Ingrid G., Levesque, Jean-Pierre

“…In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by…”
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Interaction of c-Myb with p300 Is Required for the Induction of Acute Myeloid Leukemia by Human AML Oncogenes, and Represents a Potential Therapeutic Target by Pattabiraman, Diwakar R, Shakhbazov, Konstantin, Barbier, Valerie, McGirr, Crystal, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Grimmond, Sean, Papathanasiou, Peter, Perkins, Andrew C., Levesque, Jean-Pierre, Alexander, Warren S., Winkler, Ingrid G, Gonda, Thomas J

“…Abstract 2402 The MYB oncogene is widely expressed in acute leukaemias and is important for the continued proliferation of leukemia cells, raising the…”
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Abstract A17: The dual angiogenesis/heparanase inhibitor PG545 inhibits solid tumor progression in models of breast, prostate and liver cancer: A comparative assessment of once versus twice weekly administration schedules by Hammond, Edward, Bytheway, Ian, Handley, Paul, Kappler, Michelle, McGirr, Crystal, Gonda, Thomas J., Smith, Maree, Dredge, Keith

“…Abstract PG545 is Progen's lead oncology candidate currently undergoing formal preclinical development. PG545 is a synthetic heparan sulfate (HS) mimetic that…”
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