Search Results - "McGinnis, Lisa M."

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia by Granja, Jeffrey M., Klemm, Sandy, McGinnis, Lisa M., Kathiria, Arwa S., Mezger, Anja, Corces, M. Ryan, Parks, Benjamin, Gars, Eric, Liedtke, Michaela, Zheng, Grace X. Y., Chang, Howard Y., Majeti, Ravindra, Greenleaf, William J.

“…Identifying the causes of human diseases requires deconvolution of abnormal molecular phenotypes spanning DNA accessibility, gene expression and protein…”
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Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes by Taniguchi, Cullen M, Finger, Elizabeth C, Krieg, Adam J, Wu, Colleen, Diep, Anh N, LaGory, Edward L, Wei, Kevin, McGinnis, Lisa M, Yuan, Jenny, Kuo, Calvin J, Giaccia, Amato J

“…In two separate studies, Amato Giaccia and Calvin Kuo and colleagues show that targeting of hypoxia-inducible factor-2α to increase its expression results in…”
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Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization by McGinnis, Lisa M, Ibarra‐Lopez, Veronica, Rost, Sandra, Ziai, James

“…Over the past decade, invention and adoption of novel multiplexing technologies for tissues have made increasing impacts in basic and translational research…”
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Alanine-scanning Mutations in Domain 4 of Anthrax Toxin Protective Antigen Reveal Residues Important for Binding to the Cellular Receptor and to a Neutralizing Monoclonal Antibody by Rosovitz, M.J., Schuck, Peter, Varughese, Mini, Chopra, Arun P., Mehra, Varsha, Singh, Yogendra, McGinnis, Lisa M., Leppla, Stephen H.

“…A panel of variants with alanine substitutions in the small loop of anthrax toxin protective antigen domain 4 was created to determine individual amino acid…”
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Frequency of MAP2K1, TP53, and U2AF1 Mutations in BRAF-mutated Langerhans Cell Histiocytosis: Further Characterizing the Genomic Landscape of LCH by McGinnis, Lisa M, Nybakken, Grant, Ma, Lisa, Arber, Daniel A

“…Langerhans cell histiocytosis is a proliferative disorder of neoplastic Langerhans cells with activating mutations in the Erk signaling pathway. TP53 and U2AF1…”
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Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade by Nabet, Barzin Y, Hamidi, Habib, Lee, Myung Chang, Banchereau, Romain, Morris, Stefanie, Adler, Leah, Gayevskiy, Velimir, Elhossiny, Ahmed M, Srivastava, Minu K, Patil, Namrata S, Smith, Kiandra A, Jesudason, Rajiv, Chan, Caleb, Chang, Patrick S, Fernandez, Matthew, Rost, Sandra, McGinnis, Lisa M, Koeppen, Hartmut, Gay, Carl M, Minna, John D, Heymach, John V, Chan, Joseph M, Rudin, Charles M, Byers, Lauren A, Liu, Stephen V, Reck, Martin, Shames, David S

“…Atezolizumab (anti-PD-L1), combined with carboplatin and etoposide (CE), is now a standard of care for extensive-stage small-cell lung cancer (ES-SCLC). A…”
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A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition by Wei, Kevin, Piecewicz, Stephanie M, McGinnis, Lisa M, Taniguchi, Cullen M, Wiegand, Stanley J, Anderson, Keith, Chan, Carol W-M, Mulligan, Kimberly X, Kuo, David, Yuan, Jenny, Vallon, Mario, Morton, Lori C, Lefai, Etienne, Simon, M Celeste, Maher, Jacquelyn J, Mithieux, Gilles, Rajas, Fabienne, Annes, Justin P, McGuinness, Owen P, Thurston, Gavin, Giaccia, Amato J, Kuo, Calvin J

“…In two separate studies, Amato Giaccia and Calvin Kuo and colleagues show that targeting of hypoxia-inducible factor-2α to increase its expression results in…”
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DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes by Sleckman, Barry P, Bredemeyer, Andrea L, Helmink, Beth A, Innes, Cynthia L, Calderon, Boris, McGinnis, Lisa M, Mahowald, Grace K, Gapud, Eric J, Walker, Laura M, Collins, Jennifer B, Weaver, Brian K, Mandik-Nayak, Laura, Schreiber, Robert D, Allen, Paul M, May, Michael J, Paules, Richard S, Bassing, Craig H

“…DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The…”
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Genomic Comparison of cag Pathogenicity Island (PAI)-Positive and -Negative Helicobacter pylori Strains: Identification of Novel Markers for cag PAI-Positive Strains by Terry, Courtney E, McGinnis, Lisa M, Madigan, Katharine C, Cao, Ping, Cover, Timothy L, Liechti, George W, Peek, Richard M, Forsyth, Mark H

“…In an analysis of Helicobacter pylori genomic DNA by macroarray methodology, genomic DNA from a panel of cag pathogenicity island (PAI)-negative H. pylori…”
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PDGF-B exploits stromal EPO by McGinnis, Lisa M, Kuo, Calvin J

“…A new study in mice shows that platelet-derived growth factor-B (PDGF-B) boosts tumor growth by exerting a double function after induction of erythropoietin…”
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Abstract A039: RAS signaling strength determines phenotypic response in the colon by Moore, Amanda R., Carlos, Sandra Melo, Storm, Elaine E., McGinnis, Lisa M., Malek, Shiva, de Sauvage, Frederic J.

“…Abstract The RAS (KRAS, NRAS and HRAS) genes are the most frequently mutated in cancer and are highly specific to tissue type by isoform and codon, yet the…”
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A liver Hif-2[alpha]-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition by Wei, Kevin, Piecewicz, Stephanie M, Mcginnis, Lisa M, Taniguchi, Cullen M, Wiegand, Stanley J, Anderson, Keith, Chan, Carol W-m, Mulligan, Kimberly X, Kuo, David, Yuan, Jenny, Vallon, Mario, Morton, Lori C, Lefai, Etienne, Simon, M Celeste, Maher, Jacquelyn J, Mithieux, Gilles, Rajas, Fabienne, Annes, Justin P, Mcguinness, Owen P, Thurston, Gavin, Giaccia, Amato J, Kuo, Calvin J

“…Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synthesis and lipogenesis. The liver…”
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