Search Results - "McGinn, Melissa J"

Pathophysiology of Traumatic Brain Injury by McGinn, Melissa J., PhD, Povlishock, John T., PhD

“…This article provides a concise overview, at the structural and functional level, of those changes evoked by traumatic brain injury across the spectrum of the…”
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Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal population by Greer, John E, McGinn, Melissa J, Povlishock, John T

“…Traumatic axonal injury (TAI) is a consistent component of traumatic brain injury (TBI) and is associated with much of its morbidity. Little is known regarding…”
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Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury by Sun, Dong, Bullock, M. Ross, McGinn, Melissa J., Zhou, Zhengwen, Altememi, Nabil, Hagood, Sarah, Hamm, Robert, Colello, Raymond J.

“…Stem/progenitor cells reside throughout the adult CNS and are actively dividing in the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus…”
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The effect of epidermal growth factor in the injured brain after trauma in rats by Sun, Dong, Bullock, M Ross, Altememi, Nabil, Zhou, Zhengwen, Hagood, Sarah, Rolfe, Andrew, McGinn, Melissa J, Hamm, Robert, Colello, Raymond J

“…Epidermal growth factor (EGF) is a known mitogen for neural stem and progenitor cells (NS/NPCs) in the central nervous system (CNS). In vitro, EGF maintains…”
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Cell proliferation and neuronal differentiation in the dentate gyrus in juvenile and adult rats following traumatic brain injury by Sun, Dong, Colello, Raymond J, Daugherty, Wilson P, Kwon, Taek H, McGinn, Melissa J, Harvey, H Ben, Bullock, M Ross

“…It is well known that the cognitive functions of juveniles recover to a greater extent than adult patients following traumatic brain injury (TBI). The exact…”
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Utilizing X-irradiation to selectively eliminate neural stem/progenitor cells from neurogenic regions of the mammalian brain by McGinn, Melissa J., Sun, Dong, Colello, Raymond J.

“…Neural stem/progenitor cells residing in the mammalian CNS provide a potential endogenous source for replenishing neurons that are lost due to aging, trauma or…”
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Mild traumatic brain injury in the mouse induces axotomy primarily within the axon initial segment by Greer, John E., Hånell, Anders, McGinn, Melissa J., Povlishock, John T.

“…Traumatic axonal injury (TAI) is a consistent component of traumatic brain injury (TBI), and is associated with much of its morbidity. Increasingly, it has…”
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Traumatic brain injury-induced axonal phenotypes react differently to treatment by Hånell, Anders, Greer, John E., McGinn, Melissa J., Povlishock, John T.

“…Injured axons with distinct morphologies have been found following mild traumatic brain injury (mTBI), although it is currently unclear whether they reflect…”
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Increased Intracranial Pressure after Diffuse Traumatic Brain Injury Exacerbates Neuronal Somatic Membrane Poration but not Axonal Injury: Evidence for Primary Intracranial Pressure-Induced Neuronal Perturbation by Lafrenaye, Audrey D, McGinn, Melissa J, Povlishock, John T

“…Increased intracranial pressure (ICP) associated with traumatic brain injury (TBI) is linked to increased morbidity. Although our understanding of the…”
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Crashing from cadaver to computer: Covid‐driven crisis‐mode pedagogy spawns active online substitute for teaching gross anatomy by Harrell, Kelly M., McGinn, Melissa J., Edwards, Cherie D., Warren Foster, Kenneth, Meredith, M. Alex

“…In early 2020, the Covid‐19 crisis forced medical institutions worldwide to convert quickly to online platforms for content delivery. Although many components…”
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Cadaver Rounds: A Comprehensive Exercise That Integrates Clinical Context Into Medical Gross Anatomy by Meredith, M Alex, Clemo, H Ruth, McGinn, Melissa J, Santen, Sally A, DiGiovanni, Susan R

“…PROBLEMThe purpose of medical schools is to train students to care for patients; however, the temporal and conceptual gap between course work and patient care…”
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Cellular and molecular mechanisms of injury and spontaneous recovery by McGinn, Melissa J, Povlishock, John T

“…Until recently, most have assumed that traumatic brain injury (TBI) was singularly associated with the overt destruction of brain tissue resulting in…”
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Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation by McGinn, Melissa J., Colello, Raymond J., Sun, Dong

“…In the mammalian central nervous system, generation of new neurons persists in the subventricular zone (SVZ) throughout life. However, the capacity for…”
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Anatomical integration of newly generated dentate granule neurons following traumatic brain injury in adult rats and its association to cognitive recovery by Sun, Dong, McGinn, Melissa J., Zhou, Zhengwen, Harvey, H. Ben, Bullock, M. Ross, Colello, Raymond J.

“…The hippocampus is particularly vulnerable to traumatic brain injury (TBI), the consequences of which are manifested as learning and memory deficits. Following…”
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Biochemical, Structural, and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change After Diffuse Brain Injury Uncomplicated by Contusion by McGinn, Melissa J, Kelley, Brian J, Akinyi, Linnet, Oli, Monika W, Liu, Ming Cheng, Hayes, Ronald L, Wang, Kevin K.W, Povlishock, John T

“…Calpain-mediated degradation of the cytoskeletal protein α-II-spectrin has been implicated in the pathobiology of experimental and human traumatic brain injury…”
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Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury by Kleindienst, Andrea, McGinn, Melissa J, Harvey, Harlan B, Colello, Raymond J, Hamm, Robert J, Bullock, M Ross

“…Evidence of injury-induced neurogenesis in the adult hippocampus suggests that an endogenous repair mechanism exists for cognitive dysfunction following…”
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Characterizing the mitogenic effect of basic fibroblast growth factor in the adult rat striatum by Hagood, Sarah K, McGinn, Melissa J, Sun, Dong, Colello, Raymond J

“…The limited regenerative capacity of the adult central nervous system (CNS) renders it unable to fully recover from injury or disease. Although stem and…”
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Epidermal growth factor-induced cell proliferation in the adult rat striatum by McGinn, Melissa J., Sun, Dong, Schneider, Stacie L., Alexander, John K., Colello, Raymond J.

“…Current strategies for repairing the adult CNS following injury include cell transplantation and/or the use of viral vectors to deliver therapeutic agents…”
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Age-related proteomic changes in the subventricular zone and its association with neural stem/progenitor cell proliferation by McGinn, Melissa J., Colello, Raymond J., Sun, Dong

“…In the mammalian central nervous system, generation of new neurons persists in the subventricular zone throughout life. However, the capacity of neurogenesis…”
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Biochemical, Structural and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change Following Diffuse Brain Injury Uncomplicated by Contusion by McGinn, Melissa J., Kelley, Brian J., Akinyi, Linnet, Oli, Monika W., Liu, Ming Cheng, Hayes, Ronald L., Wang, Kevin K.W., Povlishock, John T.

“…Calpain-mediated degradation of the cytoskeletal protein alpha-II-spectrin has been implicated in the pathobiology of experimental and human traumatic brain…”
Get full text