Search Results - "McGill, Mitchell R."

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis by McGill, Mitchell R., Jaeschke, Hartmut

“…ABSTRACT Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and…”
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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity by Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

“…Hepatotoxicity is a serious problem during drug development and for the use of many established drugs. For example, acetaminophen overdose is currently the…”
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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity by McGill, Mitchell R., Williams, C. David, Xie, Yuchao, Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the West. In mice, APAP hepatotoxicity can be rapidly induced with a single…”
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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation by McGill, Mitchell R, Sharpe, Matthew R, Williams, C David, Taha, Mohammad, Curry, Steven C, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a reactive metabolite that binds to…”
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Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice by Ni, Hong-Min, McGill, Mitchell R, Chao, Xiaojuan, Du, Kuo, Williams, Jessica A, Xie, Yuchao, Jaeschke, Hartmut, Ding, Wen-Xing

“…Graphical abstract…”
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Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients by McGill, Mitchell R, Jaeschke, Hartmut

“…Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose is especially common. Serum biomarkers used to follow patient progress reflect…”
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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase by Du, Kuo, Williams, C. David, McGill, Mitchell R., Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility…”
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Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice by Ramachandran, Anup, McGill, Mitchell R., Xie, Yuchao, Ni, Hong‐Min, Ding, Wen‐Xing, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the U.S., but the pathophysiology is incompletely understood…”
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Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model by Ewing, Laura E, Skinner, Charles M, Quick, Charles M, Kennon-McGill, Stefanie, McGill, Mitchell R, Walker, Larry A, ElSohly, Mahmoud A, Gurley, Bill J, Koturbash, Igor

“…The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F mice. Animals were gavaged with either 0, 246, 738, or 2460…”
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Mechanisms of acetaminophen-induced cell death in primary human hepatocytes by Xie, Yuchao, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to…”
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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis by Ward, Jeanine, Kanchagar, Chitra, Veksler-Lublinsky, Isana, Lee, Rosalind C, McGill, Mitchell R, Jaeschke, Hartmut, Curry, Steven C, Ambros, Victor R

“…We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose…”
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Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans by Williams, C. David, Bajt, Mary Lynn, Sharpe, Matthew R., McGill, Mitchell R., Farhood, Anwar, Jaeschke, Hartmut

“…Following acetaminophen (APAP) overdose there is an inflammatory response triggered by the release of cellular contents from necrotic hepatocytes into the…”
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Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity by Du, Kuo, Ramachandran, Anup, McGill, Mitchell R., Mansouri, Abdellah, Asselah, Tarik, Farhood, Anwar, Woolbright, Benjamin L., Ding, Wen-Xing, Jaeschke, Hartmut

“…Mitochondrial biogenesis (MB) is an adaptive response to maintain metabolic homeostasis after mitochondrial dysfunction. Induction of MB during APAP…”
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Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity by Du, Kuo, McGill, Mitchell R., Xie, Yuchao, Bajt, Mary Lynn, Jaeschke, Hartmut

“…•Resveratrol post-treatment protects against acetaminophen hepatotoxicity.•Resveratrol post-treatment does not affect acetaminophen-protein binding or JNK…”
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Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications by McGill, Mitchell R., Lebofsky, Margitta, Norris, Hye-Ryun K., Slawson, Matthew H., Bajt, Mary Lynn, Xie, Yuchao, Williams, C. David, Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut

“…At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the…”
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Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury by Ni, Hong-Min, Boggess, Nikki, McGill, Mitchell R, Lebofsky, Margitta, Borude, Prachi, Apte, Udayan, Jaeschke, Hartmut, Ding, Wen-Xing

“…Autophagy is an evolutionarily conserved biological process that degrades intracellular proteins and organelles including damaged mitochondria through the…”
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Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice by Bhushan, Bharat, Chavan, Hemantkumar, Borude, Prachi, Xie, Yuchao, Du, Kuo, McGill, Mitchell R, Lebofsky, Margitta, Jaeschke, Hartmut, Krishnamurthy, Partha, Apte, Udayan

“…Epidermal growth factor receptor (EGFR) plays a crucial role in hepatocyte proliferation. Its role in acetaminophen (APAP)-mediated hepatotoxicity and…”
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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes by Xie, Yuchao, McGill, Mitchell R., Du, Kuo, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Ding, Wen-Xing, Jaeschke, Hartmut

“…3′-Hydroxyacetanilide or N-acetyl-meta-aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies…”
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Bile Acid‐Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes by Woolbright, Benjamin L., McGill, Mitchell R., Yan, Huimin, Jaeschke, Hartmut

“…Cholestatic liver injury is a pathological component of numerous disease states. Much of the current literature on cholestatic liver injury is derived from…”
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Critical review of resveratrol in xenobiotic-induced hepatotoxicity by McGill, Mitchell R., Du, Kuo, Weemhoff, James L., Jaeschke, Hartmut

“…Use of natural products is increasingly popular. In fact, many patients with liver diseases self-medicate with herbal supplements. Resveratrol (RSV), in…”
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