Search Results - "McGill, Mitchell"

The past and present of serum aminotransferases and the future of liver injury biomarkers by McGill, Mitchell R

“…Laboratory testing is important in the diagnosis and monitoring of liver injury and disease. Current liver tests include plasma markers of injury (e.g…”
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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis by McGill, Mitchell R., Jaeschke, Hartmut

“…ABSTRACT Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and…”
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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans by McGill, Mitchell R

“…Our understanding of the fundamental molecular mechanisms of acetaminophen (APAP) hepatotoxicity began in 1973 to 1974, when investigators at the US National…”
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Animal models of drug-induced liver injury by McGill, Mitchell R., Jaeschke, Hartmut

“…Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and regulators. It is the most common cause of acute liver failure in…”
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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity by Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

“…Hepatotoxicity is a serious problem during drug development and for the use of many established drugs. For example, acetaminophen overdose is currently the…”
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The development and hepatotoxicity of acetaminophen: reviewing over a century of progress by McGill, Mitchell R., Hinson, Jack A.

“…Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market approximately 65 years ago. Since then, it has become one of the most used…”
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Hepatotoxicity due to herbal dietary supplements: Past, present and the future by Gurley, Bill J., McGill, Mitchell R., Koturbash, Igor

“…Dietary supplements (DS) constitute a widely used group of products comprising vitamin, mineral, and botanical extract formulations. DS of botanical or herbal…”
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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity by McGill, Mitchell R., Williams, C. David, Xie, Yuchao, Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the West. In mice, APAP hepatotoxicity can be rapidly induced with a single…”
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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation by McGill, Mitchell R, Sharpe, Matthew R, Williams, C David, Taha, Mohammad, Curry, Steven C, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a reactive metabolite that binds to…”
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Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice by Ni, Hong-Min, McGill, Mitchell R, Chao, Xiaojuan, Du, Kuo, Williams, Jessica A, Xie, Yuchao, Jaeschke, Hartmut, Ding, Wen-Xing

“…Graphical abstract…”
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The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity? by McGill, Mitchell R

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Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients by McGill, Mitchell R, Jaeschke, Hartmut

“…Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose is especially common. Serum biomarkers used to follow patient progress reflect…”
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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase by Du, Kuo, Williams, C. David, McGill, Mitchell R., Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility…”
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Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice by Ramachandran, Anup, McGill, Mitchell R., Xie, Yuchao, Ni, Hong‐Min, Ding, Wen‐Xing, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the U.S., but the pathophysiology is incompletely understood…”
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Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model by Ewing, Laura E, Skinner, Charles M, Quick, Charles M, Kennon-McGill, Stefanie, McGill, Mitchell R, Walker, Larry A, ElSohly, Mahmoud A, Gurley, Bill J, Koturbash, Igor

“…The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F mice. Animals were gavaged with either 0, 246, 738, or 2460…”
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Mechanisms of acetaminophen-induced cell death in primary human hepatocytes by Xie, Yuchao, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to…”
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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis by Ward, Jeanine, Kanchagar, Chitra, Veksler-Lublinsky, Isana, Lee, Rosalind C, McGill, Mitchell R, Jaeschke, Hartmut, Curry, Steven C, Ambros, Victor R

“…We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose…”
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Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans by Williams, C. David, Bajt, Mary Lynn, Sharpe, Matthew R., McGill, Mitchell R., Farhood, Anwar, Jaeschke, Hartmut

“…Following acetaminophen (APAP) overdose there is an inflammatory response triggered by the release of cellular contents from necrotic hepatocytes into the…”
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Biomarkers of drug-induced liver injury by McGill, Mitchell R, Jaeschke, Hartmut

“…Drug-induced liver injury (DILI) is a major clinical and regulatory challenge. As a result, interest in DILI biomarkers is growing. So far, considerable…”
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Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products by Jaeschke, Hartmut, McGill, Mitchell R., Williams, C. David, Ramachandran, Anup

“…There is a significant need to evaluate the therapeutic potential of natural products and other compounds purported to be hepatoprotective…”
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