Search Results - "McGill, Joseph"

Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses by Simhadri, Vijaya L., McGill, Joseph R., Sauna, Zuben E.

“…Immune responses to Cas proteins have been demonstrated recently and these may prove to be an impediment to their clinical use in gene editing. To make…”
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Mathematical model of a personalized neoantigen cancer vaccine and the human immune system by Rodriguez Messan, Marisabel, Yogurtcu, Osman N, McGill, Joseph R, Nukala, Ujwani, Sauna, Zuben E, Yang, Hong

“…Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4+ and CD8+ T…”
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Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population by Simhadri, Vijaya L., McGill, Joseph, McMahon, Shane, Wang, Junxia, Jiang, Haiyan, Sauna, Zuben E.

“…The repurposing of the CRISPR/Cas microbial adaptive immune system for gene editing has resulted in an exponential rise in new technologies and promising…”
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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells by Simhadri, Vijaya L., Hopkins, Louis, McGill, Joseph R., Duke, Brian R., Mukherjee, Swati, Zhang, Kate, Sauna, Zuben E.

“…CRISPR–Cas9 mediated genome editing offers unprecedented opportunities for treating human diseases. There are several reports that demonstrate pre-existing…”
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A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection by McGill, Joseph R., Lagassé, H. A. Daniel, Hernandez, Nancy, Hopkins, Louis, Jankowski, Wojciech, McCormick, Quinn, Simhadri, Vijaya, Golding, Basil, Sauna, Zuben E.

“…The emergence of the novel SARS-CoV-2 virus is the most important public-health issue of our time. Understanding the diverse clinical presentations of the…”
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TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity by Yogurtcu, Osman N., Sauna, Zuben E., McGill, Joseph R., Tegenge, Million A., Yang, Hong

“…Most immune responses to biotherapeutic proteins involve the development of anti-drug antibodies (ADAs). New drugs must undergo immunogenicity assessments to…”
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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies by Alexaki, Aikaterini, Hettiarachchi, Gaya K., Athey, John C., Katneni, Upendra K., Simhadri, Vijaya, Hamasaki-Katagiri, Nobuko, Nanavaty, Puja, Lin, Brian, Takeda, Kazuyo, Freedberg, Darón, Monroe, Dougald, McGill, Joseph R., Peters, Robert, Kames, Jacob M., Holcomb, David D., Hunt, Ryan C., Sauna, Zuben E., Gelinas, Amy, Janjic, Nebojsa, DiCuccio, Michael, Bar, Haim, Komar, Anton A., Kimchi-Sarfaty, Chava

“…Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a…”
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SampPick: Selection of a Cohort of Subjects Matching a Population HLA Distribution by McGill, Joseph R, Yogurtcu, Osman N, Verthelyi, Daniela, Yang, Hong, Sauna, Zuben E

“…Immune responses to therapeutic proteins and peptides can adversely affect their safety and efficacy; consequently, immunogenicity risk-assessments are part of…”
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HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdataset by McGill, Joseph R., Simhadri, Vijaya L., Sauna, Zuben E.

“…In hemophilia A (HA) patients, F8 gene-defects as genetic risk-factors for developing inhibitors to Factor VIII have been extensively studied. Here we provide…”
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The effect of uncertainty and asset co-specialization on governance in biotechnology alliances by Santoro, Michael D., McGill, Joseph P.

“…We explore transaction cost economics (TCE) and real option (RO) rationales for alliance governance and find the predictive power of each depends upon the type…”
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Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis by Xiao, Jerry, McGill, Joseph R., Stanton, Kelly, Kassner, Joshua D., Choudhury, Sujata, Schlegel, Richard, Sauna, Zuben E., Pohlmann, Paula R., Agarwal, Seema

“…Circulating tumor cells (CTCs) represent a unique population of cells that can be used to investigate the mechanistic underpinnings of metastasis…”
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Translational and transcriptional responses in human primary hepatocytes under hypoxia by Hettiarachchi, Gaya K, Katneni, Upendra K, Hunt, Ryan C, Kames, Jacob M, Athey, John C, Bar, Haim, Sauna, Zuben E, McGill, Joseph R, Ibla, Juan C, Kimchi-Sarfaty, Chava

“…The liver is the primary source of a large number of plasma proteins and plays a critical role in multiple biological processes. Inadequate oxygen supply…”
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Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231 by Xiao, Jerry, McGill, Joseph R., Nasir, Apsra, Lekan, Alexander, Johnson, Bailey, Wilkins, Devan J., Pearson, Gray W., Tanner, Kandice, Goodarzi, Hani, Glasgow, Eric, Schlegel, Richard, Agarwal, Seema

“…Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer metastasis…”
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Phase 1 study of DS‐1205c combined with gefitinib for EGFR mutation‐positive non‐small cell lung cancer by Goto, Koichi, Shiraishi, Yoshimasa, Murakami, Haruyasu, Horinouchi, Hidehito, Toyozawa, Ryo, Takeda, Masayuki, Uno, Makiko, Crawford, Nigel, McGill, Joseph, Jimbo, Takeshi, Ishigami, Masato, Takayama, Gensuke, Nakayama, Shintaro, Ohwada, Shoichi, Nishio, Makoto

“…Background Tyrosine kinase inhibitors (TKIs) are effective for the treatment of non‐small cell lung cancer (NSCLC) patients with activating mutations of the…”
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Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p by Jankowska, Katarzyna I., McGill, Joseph, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Sauna, Zuben E., Atreya, Chintamani D.

“…Hemophilia A (HA) is a F8 gene mutational disorder resulting in deficiency or dysfunctional FVIII protein. However, surprisingly, in few cases, HA is…”
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Structural, functional, and immunogenicity implications of F9 gene recoding by Katneni, Upendra K., Alexaki, Aikaterini, Hunt, Ryan C., Hamasaki-Katagiri, Nobuko, Hettiarachchi, Gaya K., Kames, Jacob M., McGill, Joseph R., Holcomb, David D., Athey, John C., Lin, Brian, Parunov, Leonid A., Kafri, Tal, Lu, Qi, Peters, Robert, Ovanesov, Mikhail V., Freedberg, Darón I., Bar, Haim, Komar, Anton A., Sauna, Zuben E., Kimchi-Sarfaty, Chava

“…Hemophilia B is a blood clotting disorder caused by deficient activity of coagulation factor IX (FIX). Multiple recombinant FIX proteins are currently approved…”
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Alliance Portfolios and Patent Output: The Case of Biotechnology Alliances by McGill, J.P., Santoro, M.D.

“…This paper explores how firmspsila alliance portfolios are related to patent output in the biotechnology industry. We propose that patent output is related to…”
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The Art and Science of Child Custody Evaluations by McGill, Joseph C

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Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue by Jankowski, Wojciech, McGill, Joseph, Lagassé, H.A.Daniel, Surov, Stepan, Bembridge, Gary, Bunce, Campbell, Cloake, Edward, Fogg, Mark H., Jankowska, Katarzyna I., Khan, Abdul, Marcotrigiano, Joseph, Ovanesov, Mikhail V., Sauna, Zuben E.

“…Vatreptacog alfa (VA), a recombinant activated human factor VII (rFVIIa) variant with 3 amino acid substitutions, was developed to provide increased…”
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Clinical manifestation of hemophilia A in the absence of mutations in the F8 gene that encodes FVIII: role of microRNAs by Jankowska, Katarzyna I., McGill, Joseph, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Atreya, Chintamani D., Sauna, Zuben E.

“…BACKGROUND Hemophilia A (HA) is associated with mutations in the F8 gene that expresses factor VIII (FVIII). Unexpectedly, HA also manifests in a small subset…”
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