Search Results - "McGhee, Jerry R."

Inside the mucosal immune system by McGhee, Jerry R, Fujihashi, Kohtaro

“…An intricate network of innate and immune cells and their derived mediators function in unison to protect us from toxic elements and infectious microbial…”
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Adipose-Derived Mesenchymal Stem Cells Restore Impaired Mucosal Immune Responses in Aged Mice by Aso, Kazuyoshi, Tsuruhara, Akitoshi, Takagaki, Kentaro, Oki, Katsuyuki, Ota, Megumi, Nose, Yasuhiro, Tanemura, Hideki, Urushihata, Naoki, Sasanuma, Jinichi, Sano, Masayuki, Hirano, Atsuyuki, Aso, Rio, McGhee, Jerry R, Fujihashi, Kohtaro

“…It has been shown that adipose-derived mesenchymal stem cells (AMSCs) can differentiate into adipocytes, chondrocytes and osteoblasts. Several clinical trials…”
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Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells by Tsuruhara, Akitoshi, Aso, Kazuyoshi, Tokuhara, Daisuke, Ohori, Junichiro, Kawabata, Masaki, Kurono, Yuichi, McGhee, Jerry R, Fujihashi, Kohtaro

“…Age-associated alterations in the mucosal immune system are generally termed mucosal immunosenescence. The major change seen in the aged mucosa is a failure to…”
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A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity by Fukuiwa, Tatsuya, Sekine, Shinichi, Kobayashi, Ryoki, Suzuki, Hideaki, Kataoka, Kosuke, Gilbert, Rebekah S, Kurono, Yuichi, Boyaka, Prosper N, Krieg, Arthur M, McGhee, Jerry R, Fujihashi, Kohtaro

“…Abstract We explore cellular and molecular mechanisms of nasal adjuvant of a combination of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG…”
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Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses by Fukuyama, Yoshiko, Tokuhara, Daisuke, Sekine, Shinichi, Aso, Kazuyoshi, Kataoka, Kosuke, Davydova, Julia, Yamamoto, Masato, Gilbert, Rebekah S, Tokuhara, Yuka, Fujihashi, Keiko, Kunisawa, Jun, Yuki, Yoshikazu, Kiyono, Hiroshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following…”
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Gut lymphocyte migration: we are halfway ‘home’ by McGhee, Jerry R, Kunisawa, Jun, Kiyono, Hiroshi

“…The gastrointestinal immune system consists of immune cells in organized gut-associated lymphoreticular tissues (GALT) and diffuse lamina propria, which give…”
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Mechanisms for Induction of Acquired Host Immunity by Neutrophil Peptide Defensins by Lillard, James W., Boyaka, Prosper N., Chertov, Oleg, Oppenheim, Joost J., McGhee, Jerry R.

“…Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus…”
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A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration by Sekine, Shinichi, Kataoka, Kosuke, Fukuyama, Yoshiko, Adachi, Yasuo, Davydova, Julia, Yamamoto, Masato, Kobayashi, Ryoki, Fujihashi, Keiko, Suzuki, Hideaki, Curiel, David T, Shizukuishi, Satoshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated…”
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Pneumococcal Carriage Results in Ganglioside-Mediated Olfactory Tissue Infection by van Ginkel, Frederik W., McGhee, Jerry R., Watt, James M., Campos-Torres, Antonio, Parish, Lindsay A., Briles, David E.

“…Streptococcus pneumoniae cause considerable morbidity and mortality, with persistent neurological sequelae, particularly in young children and the elderly. It…”
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Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity by Yamamoto, Masafumi, Kweon, Mi-Na, Rennert, Paul D, Hiroi, Takachika, Fujihashi, Kohtaro, McGhee, Jerry R, Kiyono, Hiroshi

“…This study assessed the roles of the postnatal lymphotoxin-beta receptor (LTbetaR)-mediated signals in the gut-associated lymphoreticular tissues of mice for…”
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Enterotoxin-Based Mucosal Adjuvants Alter Antigen Trafficking and Induce Inflammatory Responses in the Nasal Tract by VAN GINKEL, Frederik W, JACKSON, Raymond J, YOSHINO, Naoto, HAGIWARA, Yukari, METZGER, Daniel J, CONNELL, Terry D, VU, Hong L, MARTIN, Michael, FUJIHASHI, Kohtaro, MCGHEE, Jerry R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Nasal Flt3 Ligand cDNA Elicits CD11c+CD8+ Dendritic Cells for Enhanced Mucosal Immunity by Kataoka, Kosuke, McGhee, Jerry R, Kobayashi, Ryoki, Fujihashi, Keiko, Shizukuishi, Satoshi, Fujihashi, Kohtaro

“…Nasal immunization is an effective way to induce both mucosal and systemic immune responses. In this study, we assessed a cDNA vector for Flt3 ligand (FL) for…”
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A Second Generation of Double Mutant Cholera Toxin Adjuvants: Enhanced Immunity without Intracellular Trafficking by Hagiwara, Yukari, Kawamura, Yuki I, Kataoka, Kosuke, Rahima, Bibi, Jackson, Raymond J, Komase, Katsuhiro, Dohi, Taeko, Boyaka, Prosper N, Takeda, Yoshifumi, Kiyono, Hiroshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…Nasal application of native cholera toxin (nCT) as a mucosal adjuvant has potential toxicity for the CNS through binding to GM1 gangliosides in the olfactory…”
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Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice by Fischer, Romy, Tomé, Daniel, McGhee, Jerry R., Boyaka, Prosper N.

“…Most current animal models focus on eosinophil-mediated asthma, despite compelling evidence that a neutrophil-mediated disease occurs in some asthma patients…”
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Novel vaccine development strategies for inducing mucosal immunity by Fujkuyama, Yoshiko, Tokuhara, Daisuke, Kataoka, Kosuke, Gilbert, Rebekah S, McGhee, Jerry R, Yuki, Yoshikazu, Kiyono, Hiroshi, Fujihashi, Kohtaro

“…To develop protective immune responses against mucosal pathogens, the delivery route and adjuvants for vaccination are important. The host, however, strives to…”
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RANTES Potentiates Antigen-Specific Mucosal Immune Responses by Lillard, James W., Jr, Boyaka, Prosper N, Taub, Dennis D, McGhee, Jerry R

“…RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of…”
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Vaccines for mucosal immunity to combat emerging infectious diseases by van Ginkel, F W, Nguyen, H H, McGhee, J R

“…The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal…”
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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly by Fukuyama, Yoshiko, Ikeda, Yorihiko, Ohori, Junichiro, Sugita, Gen, Aso, Kazuyoshi, Fujihashi, Keiko, Briles, David E, McGhee, Jerry R, Fujihashi, Kohtaro

“…Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it…”
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Evidence For Early Aging in the Mucosal Immune System by Koga, Toshiya, McGhee, Jerry R, Kato, Hirotomo, Kato, Rie, Kiyono, Hiroshi, Fujihashi, Kohtaro

“…Despite recent advances in the cellular and molecular analysis of induction and regulation of mucosal immune responses, little is yet known about differences…”
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Heterosubtypic Immunity to Influenza A Virus Infection Requires B Cells but Not CD8+ Cytotoxic T Lymphocytes by Nguyen, Huan H., van Ginkel, Frederik W., Vu, Huong L., McGhee, Jerry R., Mestecky, Jiri

“…Heterosubtypic immunity (HSI), defined as protective cross-reactivity to lethal infection with influenza A virus of a serotype different from the virus…”
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