Search Results - "McGhee, Claire"
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DNAzyme sensors for detection of metal ions in the environment and imaging them in living cells
Published in Current opinion in biotechnology (01-06-2017)“…Highlights • DNAzymes are an emerging class of metal ions sensors with high selectivity. • Recent progress has been made in using DNAzymes for environmental…”
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PNA-Assisted DNAzymes to Cleave Double-Stranded DNA for Genetic Engineering with High Sequence Fidelity
Published in Journal of the American Chemical Society (07-07-2021)“…DNAzymes have been widely used in many sensing and imaging applications but have rarely been used for genetic engineering since their discovery in 1994,…”
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In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing
Published in Proceedings of the National Academy of Sciences - PNAS (12-05-2015)“…Over the past two decades, enormous progress has been made in designing fluorescent sensors or probes for divalent metal ions. In contrast, the development of…”
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Evidence of a General Acid–Base Catalysis Mechanism in the 8–17 DNAzyme
Published in Biochemistry (Easton) (06-03-2018)“…DNAzymes are catalytic DNA molecules that can perform a variety of reactions. Although advances have been made in obtaining DNAzymes via in vitro selection and…”
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Longest sediment flows yet measured show how major rivers connect efficiently to deep sea
Published in Nature communications (20-07-2022)“…Here we show how major rivers can efficiently connect to the deep-sea, by analysing the longest runout sediment flows (of any type) yet measured in action on…”
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DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons
Published in ACS central science (24-11-2021)“…Lithium has been a drug for bipolar disorders (BD) for over 70 years; however, its usage has been limited by its narrow therapeutic window (between 0.6 and 1.2…”
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Applications of Synchrotron-Based Spectroscopic Techniques in Studying Nucleic Acids and Nucleic Acid-Functionalized Nanomaterials
Published in Advanced materials (Weinheim) (10-12-2014)“…In this review, we summarize recent progress in the application of synchrotron‐based spectroscopic techniques for nucleic acid research that takes advantage of…”
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A Highly Selective Mn(II)-Specific DNAzyme and Its Application in Intracellular Sensing
Published in JACS Au (26-06-2023)“…Manganese is an essential trace element in the human body that acts as a cofactor in many enzymes and metabolisms. It is important to develop methods to detect…”
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First source-to-sink monitoring shows dense head controls sediment flux and runout in turbidity currents
Published in Science advances (20-05-2022)“…Until recently, despite being one of the most important sediment transport phenomena on Earth, few direct measurements of turbidity currents existed…”
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Morphometric fingerprints and downslope evolution in bathymetric surveys: insights into morphodynamics of the Congo canyon-channel
Published in Frontiers in earth science (Lausanne) (23-05-2024)“…Submarine canyons and channels are globally important pathways for sediment, organic carbon, nutrients and pollutants to the deep sea, and they form the…”
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Time-lapse surveys reveal patterns and processes of erosion by exceptionally powerful turbidity currents that flush submarine canyons: A case study of the Congo Canyon
Published in Geomorphology (Amsterdam, Netherlands) (15-10-2024)“…The largest canyons on Earth occur on the seafloor, and seabed sediment flows called turbidity currents play a key role in carving these submarine canyons…”
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Carbon and sediment fluxes inhibited in the submarine Congo Canyon by landslide-damming
Published in Nature geoscience (01-10-2022)“…Landslide-dams, which are often transient, can strongly affect the geomorphology, and sediment and geochemical fluxes, within subaerial fluvial systems. The…”
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Stratigraphy and sedimentary evolution of a modern macro‐tidal incised valley: An analogue for reservoir facies and architecture
Published in Sedimentology (01-02-2022)“…Incised valley fills are complex as they correspond to multiple sea‐level cycles which makes interpretation and correlation of stratigraphic surfaces fraught…”
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Turbidity Currents Can Dictate Organic Carbon Fluxes Across River‐Fed Fjords: An Example From Bute Inlet (BC, Canada)
Published in Journal of geophysical research. Biogeosciences (01-06-2022)“…The delivery and burial of terrestrial particulate organic carbon (OC) in marine sediments is important to quantify, because this OC is a food resource for…”
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