Search Results - "McGettrick, Helen"

Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards by Munir, Hafsa, McGettrick, Helen M

“…Mesenchymal stem cells (MSC) possess a range of immunomodulatory properties which they exert through soluble mediators and through direct cell-cell contact…”
Get more information

Distinct fibroblast subsets drive inflammation and damage in arthritis by Croft, Adam P., Campos, Joana, Jansen, Kathrin, Turner, Jason D., Marshall, Jennifer, Attar, Moustafa, Savary, Loriane, Wehmeyer, Corinna, Naylor, Amy J., Kemble, Samuel, Begum, Jenefa, Dürholz, Kerstin, Perlman, Harris, Barone, Francesca, McGettrick, Helen M., Fearon, Douglas T., Wei, Kevin, Raychaudhuri, Soumya, Korsunsky, Ilya, Brenner, Michael B., Coles, Mark, Sansom, Stephen N., Filer, Andrew, Buckley, Christopher D.

“…The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated…”
Get full text

Bridging the gap—Immune cells that can repair nerves by McGettrick, Helen M.

Get full text

Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium by Munir, Hafsa, Luu, Nguyet-Thin, Clarke, Lewis S C, Nash, Gerard B, McGettrick, Helen M

“…Mesenchymal stromal cells (MSC) are tissue-resident stromal cells capable of modulating immune responses, including leukocyte recruitment by endothelial cells…”
Get full text

The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone by Frost, Kathryn, Naylor, Amy J, McGettrick, Helen M

“…Bone remodelling is a highly active and dynamic process that involves the tight regulation of osteoblasts, osteoclasts, and their progenitors to allow for a…”
Get full text

Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target by Hughes, Michael J, McGettrick, Helen M, Sapey, Elizabeth

“…Multimorbidity is increasingly common and current healthcare strategies are not always aligned to treat this complex burden of disease. COPD, type-2 diabetes…”
Get full text

Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner by Hopkin, Sophie J, Pezhman, Laleh, Begum, Jenefa, Kavanagh, Dean, McGettrick, Helen M, Iqbal, Asif J, Chimen, Myriam

“…Aging is associated with exacerbated systemic inflammation (inflammaging) and the progressive loss of immune system function (immunosenescence). Leukocyte…”
Get full text

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface by Chimen, Myriam, Yates, Clara M, McGettrick, Helen M, Ward, Lewis S C, Harrison, Matthew J, Apta, Bonita, Dib, Lea H, Imhof, Beat A, Harrison, Paul, Nash, Gerard B, Rainger, G Ed

“…Two major monocyte subsets, CD14 CD16 (classical) and CD14 CD16 (nonclassical/intermediate), have been described. Each has different functions ascribed in its…”
Get full text

Importance of validating antibody panels: Anti-PD-L1 clone binds AF700 fluorophore by Hughes, Michael J., McGettrick, Helen M., Sapey, Elizabeth

“…Researchers routinely use antibodies to assess the expression levels of proteins on the surface or intracellularly in a variety of different cell types. In…”
Get full text

Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis by Buckley, Christopher D., McGettrick, Helen M.

“…The trafficking of leukocytes from their site of production in the bone marrow through the circulation and into peripheral tissues is a highly coordinated and…”
Get full text

Shear Stress Regulated Gene Expression and Angiogenesis in Vascular Endothelium by Wragg, Joseph W., Durant, Sarah, McGettrick, Helen M., Sample, Klarke M., Egginton, Stuart, Bicknell, Roy

“…The behavior of vascular EC is greatly altered in sites of pathological angiogenesis, such as a developing tumor or atherosclerotic plaque. Until recently it…”
Get full text

Adipogenic Differentiation of Mesenchymal Stem Cells Alters Their Immunomodulatory Properties in a Tissue‐Specific Manner by Munir, Hafsa, Ward, Lewis S. C., Sheriff, Lozan, Kemble, Samuel, Nayar, Saba, Barone, Francesca, Nash, Gerard B., McGettrick, Helen M.

“…Chronic inflammation is associated with formation of ectopic fat deposits that might represent damage‐induced aberrant mesenchymal stem cell (MSC)…”
Get full text

The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse by Frost, Kathryn, Lewis, Jonathan W, Jones, Simon W, Edwards, James R, Naylor, Amy J, McGettrick, Helen M

“…The deterioration of osteoblast-led bone formation and the upregulation of osteoclast-regulated bone resorption are the primary causes of bone diseases,…”
Get full text

Vascular Endothelial Galectins in Leukocyte Trafficking by Lightfoot, Abbey, McGettrick, Helen M., Iqbal, Asif J.

“…Leukocyte recruitment to the site of injury is a crucial event in the regulation of an inflammatory response. Tight regulation of interactions between the…”
Get full text

Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets by Ward, Lewis S C, Sheriff, Lozan, Marshall, Jennifer L, Manning, Julia E, Brill, Alexander, Nash, Gerard B, McGettrick, Helen M

“…Mesenchymal stromal cells (MSCs) upregulate podoplanin at sites of infection, chronic inflammation and cancer. Here, we investigated the functional…”
Get full text

Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health by Weaver, Samuel R., Rendeiro, Catarina, McGettrick, Helen M., Philp, Andrew, Lucas, Samuel J. E.

“…Purpose Red wine polyphenols (RWP) are plant-based molecules that have been extensively studied in relation to their protective effects on vascular health in…”
Get full text

Polymyalgia rheumatica shows metabolomic alterations that are further altered by glucocorticoid treatment: Identification of metabolic correlates of fatigue by Manning, Julia E., Harris, Emma, Mathieson, Hannah, Sorensen, Louise, Luqmani, Raashid, McGettrick, Helen M., Morgan, Ann W., Young, Stephen P., Mackie, Sarah L.

“…In polymyalgia rheumatica (PMR), glucocorticoids (GCs) relieve pain and stiffness, but fatigue may persist. We aimed to explore the effect of disease, GCs and…”
Get full text

Adiponectin signalling in bone homeostasis, with age and in disease by Lewis, Jonathan W, Edwards, James R, Naylor, Amy J, McGettrick, Helen M

“…Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin resistance. Within the bone, osteoblasts and…”
Get full text

Non-pharmacological interventions for vascular health and the role of the endothelium by Weaver, Samuel R. C., Rendeiro, Catarina, Lucas, Rebekah A. I., Cable, N. Timothy, Nightingale, Tom E., McGettrick, Helen M., Lucas, Samuel J. E.

“…The most common non-pharmacological intervention for both peripheral and cerebral vascular health is regular physical activity (e.g., exercise training), which…”
Get full text

Galectin-9: A novel promoter of atherosclerosis progression by Krautter, Franziska, Hussain, Mohammed T., Zhi, Zhaogong, Lezama, Danielle R., Manning, Julia E., Brown, Emily, Marigliano, Noemi, Raucci, Federica, Recio, Carlota, Chimen, Myriam, Maione, Francesco, Tiwari, Alok, McGettrick, Helen M., Cooper, Dianne, Fisher, Edward A., Iqbal, Asif J.

“…Atherosclerosis is widely accepted to be an inflammatory disease driven by lipid accumulation and leukocyte recruitment. More recently, galectins, a family of…”
Get full text