Search Results - "McGeer, P.L."

Neurotoxins released from interferon-gamma-stimulated human astrocytes by Lee, M, McGeer, E, McGeer, P.L

“…Highlights ► IFNγ-stimulated astrocytes release neurotoxic factors. ► We investigated their type and relative contribution in vitro . ► Cytokines, proteases,…”
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Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys by Miklossy, J., Doudet, D.D., Schwab, C., Yu, S., McGeer, E.G., McGeer, P.L.

“…It has been established that neuroinflammation is present in the substantia nigra (SN) of Parkinson disease (PD) cases but the factors responsible are as yet…”
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Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain by Yasojima, K, McGeer, E.G, McGeer, P.L

“…β-Amyloid peptide (Aβ) is generated by two cleavages of amyloid precursor protein (APP). The initial cleavage by BACE is followed by γ-secretase cleavage of…”
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2.206 EPIGALLOCAETECHIN GALLATE (EGCG) INHIBITS A-SYNUCLEIN AGGREGATION: A POTENTIAL AGENT FOR PARKINSON DISEASE by Zhang, Y, Xu, Y, Deng, Y, Wong, W, McGeer, P.L, Qing, H

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Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease by Webster, S, Lue, L.-F, Brachova, L, Tenner, A.J, McGeer, P.L, Terai, K, Walker, D.G, Bradt, B, Cooper, N.R, Rogers, J

“…The membrane attack complex, C5b-9, is of considerable importance in many inflammatory reactions. It is the terminal, cytolytic component of both classical and…”
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Neurons express proteins of the classical complement pathway in Alzheimer disease by Terai, K, Walker, D.G, McGeer, E.G, McGeer, P.L

“…Occurrence of the classical pathway complement proteins C1q, C1r, C1s, C2, C3, C4, C5, C6, C7, C8 and C9 was studied in human hippocampus and temporal cortex…”
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Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs) by Klegeris, A., Walker, D.G., McGeer, P.L.

“…There is mounting evidence that inflammatory processes, including activation of microglia, are upregulated in Alzheimer’s disease. The importance of this…”
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P2-167: Alzheimer disease tangles and threads display multiple tau phosphorylation sites by Guo, J.J, Schwab, Claudia, Li, D.H, Liu, J, Po, C, McGeer, P.L

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Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K by Yamada, T, McGeer, P L, Baimbridge, K G, McGeer, E G

“…The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single…”
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Distribution of clusterin in Alzheimer brain tissue by McGeer, P L, Kawamata, T, Walker, D G

“…The immunohistochemical distribution of clusterin (SP40,40, SGP-2) was determined in Alzheimer disease (AD) and normal human brain tissue and compared with the…”
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Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA by Yasojima, K., McGeer, E.G., McGeer, P.L.

“…We measured the relative levels of exon 10 containing and exon 10 deleted tau mRNAs in multiple areas of Alzheimer disease (AD) and normal brain. Compared with…”
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Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells by Klegeris, A, Walker, D.G, McGeer, P.L

“…Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role…”
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Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease by Tooyama, I, Kimura, H, Akiyama, H, McGeer, P L

“…Expression of major histocompatibility complex (MHC) class I (HLA-A,B,C) and class II (HLA-DR) antigens was studied in postmortem brain tissue of Alzheimer's…”
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Midkine, a novel neurotrophic factor, is present in senile plaques of Alzheimer disease by Yasuhara, O, Muramatsu, H, Kim, S U, Muramatsu, T, Maruta, H, McGeer, P L

“…An affinity purified antibody specific for midkine (MK) stained senile plaques in the brain of Alzheimer disease (AD) patients. After formic acid treatment,…”
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Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease by Walker, D.G., Yasuhara, O., Patston, P.A., McGeer, E.G., McGeer, P.L.

“…C1 inhibitor was identified in human brain tissue by Western blotting and by immunohistochemistry using multiple antibodies to the native protein. The presence…”
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Distribution of choline acetyltransferase immunopositive structures in the rat brainstem by Tago, H, McGeer, P L, McGeer, E G, Akiyama, H, Hersh, L B

“…The distribution of neurons, fibers and terminal fields in rat brainstem displaying positive immunoreactivity to a polyclonal antiserum to human placental…”
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Lrrk2 interaction with α-synuclein in diffuse Lewy body disease by Qing, Hong, Zhang, Yanyan, Deng, Yulin, McGeer, E.G., McGeer, P.L.

“…Mutations of the leucine-rich repeat kinase 2 ( LRRK2) gene are the leading cause of genetically inherited Parkinson’s disease (PD) and its more severe variant…”
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PrP Conformational Transitions Alter Species Preference of a PrP-specific Antibody by Zou, Wen-Quan, Langeveld, Jan, Xiao, Xiangzhu, Chen, Shugui, McGeer, Patrick L., Yuan, Jue, Payne, Michael C., Kang, Hae-Eun, McGeehan, John, Sy, Man-Sun, Greenspan, Neil S., Kaplan, David, Wang, Gong-Xian, Parchi, Piero, Hoover, Edward, Kneale, Geoff, Telling, Glenn, Surewicz, Witold K., Kong, Qingzhong, Guo, Jian-Ping

“…The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to…”
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Brain microglia constitutively express beta-2 integrins by Akiyama, H, McGeer, P L

“…Localization of beta-2 integrins in normal and Alzheimer disease temporal cortex was studied immunohistochemically. Resting microglia were found to express…”
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Aβ42-Carboxy-Terminal-like Immunoreactivity Is Associated with Intracellular Neurofibrillary Tangles and Pick Bodies by Schwab, C., McGeer, P.L.

“…Co-occurrence of neurofibrillary tangles (NFTs) and β-amyloid (Aβ)-containing plaques is the pathological hallmark of Alzheimer's disease (AD). Much research…”
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