Search Results - "McGavin, Martin J"

Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages by Flannagan, Ronald S, Kuiack, Robert C, McGavin, Martin J, Heinrichs, David E

“…Macrophages are critical to innate immunity due to their ability to phagocytose bacteria. The macrophage phagolysosome is a highly acidic organelle with potent…”
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Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence by Goncheva, Mariya I., Flannagan, Ronald S., Sterling, Brigid E., Laakso, Holly A., Friedrich, Nancy C., Kaiser, Julienne C., Watson, David W., Wilson, Christy H., Sheldon, Jessica R., McGavin, Martin J., Kiser, Patti K., Heinrichs, David E.

“…Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis,…”
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Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus by Bonn, Camryn M, Rafiqullah, Iftekhar M, Crawford, John A, Qian, Yi Meng, Guthrie, Jennifer L, Matuszewska, Marta, Robinson, D Ashley, McGavin, Martin J

“…Resistance-nodulation-division (RND) superfamily efflux pumps promote antibiotic resistance in Gram-negative pathogens, but their role in Gram-positive…”
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Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus by DeLeo, Frank R, Kennedy, Adam D, Chen, Liang, Wardenburg, Juliane Bubeck, Kobayashi, Scott D, Mathema, Barun, Braughton, Kevin R, Whitney, Adeline R, Villaruz, Amer E, Martens, Craig A, Porcella, Stephen F, McGavin, Martin J, Otto, Michael, Musser, James M, Kreiswirth, Barry N

“…Staphylococcus aureus is a bacterial pathogen known to cause infections in epidemic waves. One such epidemic was caused by a clone known as phage-type 80/81, a…”
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Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus by Arsic, Benjamin, Zhu, Yue, Heinrichs, David E, McGavin, Martin J

“…Community acquired methicillin resistant Staphylococcus aureus (CA-MRSA), and the USA300 strain of CA-MRSA in particular, are known for their rapid community…”
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Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection by Burlak, Christopher, Hammer, Carl H, Robinson, Mary-Ann, Whitney, Adeline R, McGavin, Martin J, Kreiswirth, Barry N, DeLeo, Frank R

“…Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a threat to human health worldwide. Although progress has been made, mechanisms…”
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Rapid autocatalytic activation of the M4 metalloprotease aureolysin is controlled by a conserved N-terminal fungalysin-thermolysin-propeptide domain by Nickerson, Nicholas N, Joag, Vineet, McGavin, Martin J

“…The Staphylococcus aureus proteolytic cascade consists of a metalloprotease aureolysin (Aur), which activates a serine protease zymogen proSspA, which in turn…”
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Activation of the SspA Serine Protease Zymogen of Staphylococcus aureus Proceeds through Unique Variations of a Trypsinogen-like Mechanism and Is Dependent on Both Autocatalytic and Metalloprotease-specific Processing by Nickerson, Nicholas N., Prasad, Lata, Jacob, Latha, Delbaere, Louis T., McGavin, Martin J.

“…The serine and cysteine proteases SspA and SspB of Staphylococcus aureus are secreted as inactive zymogens, zSspA and zSspB. Mature SspA is a trypsin-like…”
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Staphylococcus δ-toxin induces allergic skin disease by activating mast cells by Nakamura, Yuumi, Oscherwitz, Jon, Cease, Kemp B., Chan, Susana M., Muñoz-Planillo, Raul, Hasegawa, Mizuho, Villaruz, Amer E., Cheung, Gordon Y. C., McGavin, Martin J., Travers, Jeffrey B., Otto, Michael, Inohara, Naohiro, Núñez, Gabriel

“…Staphylococcus aureus δ-toxin is an inducer of mast cell degranulation in mice and is important for promoting inflammatory skin disease. Bacterial link in…”
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Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30 by McGavin, Martin J, Arsic, Benjamin, Nickerson, Nicholas N

“…Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more than 60 years, and, therefore, provides a model system to evaluate how…”
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The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth by Kuiack, Robert C, Tuffs, Stephen W, Dufresne, Karine, Flick, Robert, McCormick, John K, McGavin, Martin J

“…In Staphylococcus aureus, genes that should confer the capacity to metabolize fatty acids by β-oxidation occur in the fadXDEBA locus, but their function has…”
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Description of Staphylococcus Serine Protease (ssp) Operon in Staphylococcus aureus and Nonpolar Inactivation of sspA-Encoded Serine Protease by RICE, Kelly, PERALTA, Robert, BAST, Darrin, DE AZAVEDO, Joyce, MCGAVIN, Martin J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH by Kuiack, Robert C, Veldhuizen, Ruud A W, McGavin, Martin J

“…Although the GraS sensor kinase of is known for the sensing of and resistance to cationic antimicrobial peptides (CAMPs), we recently established that it also…”
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Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA by El-Halfawy, Omar M., Czarny, Tomasz L., Flannagan, Ronald S., Day, Jonathan, Bozelli, José Carlos, Kuiack, Robert C., Salim, Ahmed, Eckert, Philip, Epand, Richard M., McGavin, Martin J., Organ, Michael G., Heinrichs, David E., Brown, Eric D.

“…Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed…”
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Role of Lipase from Community-Associated Methicillin-Resistant Staphylococcus aureus Strain USA300 in Hydrolyzing Triglycerides into Growth-Inhibitory Free Fatty Acids by Cadieux, Brigitte, Vijayakumaran, Vithooshan, Bernards, Mark A, McGavin, Martin J, Heinrichs, David E

“…Part of the human host innate immune response involves the secretion of bactericidal lipids on the skin and delivery of triglycerides into abscesses to control…”
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DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus by Alnaseri, Heba, Kuiack, Robert C, Ferguson, Katherine A, Schneider, James E T, Heinrichs, David E, McGavin, Martin J

“…Divergent genes in USA300 encode the efflux pump FarE and TetR family regulator FarR, which confer resistance to antimicrobial unsaturated fatty acids. To…”
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Molecular Analysis of the Accessory Gene Regulator (agr) Locus and Balance of Virulence Factor Expression in Epidemic Methicillin-Resistant Staphylococcus aureus by Papakyriacou, Helen, Vaz, Dareyl, Simor, Andrew, Louie, Marie, McGavin, Martin J.

“…Potential relationships between virulence factor expression and transmissibility were assessed in epidemic methicillin-resistant Staphylococcus aureus (MRSA)…”
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Staphylococcus aureus keratinocyte invasion is mediated by integrin‐linked kinase and Rac1 by Sayedyahossein, Samar, Xu, Stacey X., Rudkouskaya, Alena, McGavin, Martin J., McCormick, John K., Dagnino, Lina

“…ABSTRACT Staphylococcus aureus is a major component of the skin microbiota and causes a large number of serious infections. S. aureus first interacts with…”
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Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids by Alnaseri, Heba, Arsic, Benjamin, Schneider, James E. T, Kaiser, Julienne C, Scinocca, Zachariah C, Heinrichs, David E, McGavin, Martin J

“…Although Staphylococcus aureus is exposed to antimicrobial fatty acids on the skin, in nasal secretions, and in abscesses, a specific mechanism of inducible…”
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Impact of accessory gene regulator (agr) dysfunction on vancomycin pharmacodynamics among Canadian community and health-care associated methicillin-resistant Staphylococcus aureus by Tsuji, Brian T, MacLean, Robert D, Dresser, Linda D, McGavin, Martin J, Simor, Andrew E

“…The accessory gene regulator (agr) is a quorum sensing cluster of genes which control colonization and virulence in Staphylococcus aureus. We evaluated agr…”
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