Search Results - "McGarry, David J."
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MICAL1 activation by PAK1 mediates actin filament disassembly
Published in Cell reports (Cambridge) (04-10-2022)“…The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin) structures. Although MICAL1 has been shown to be regulated via…”
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A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids
Published in ACS chemical biology (16-12-2016)“…Reactive oxygen species act as important second messengers in cell signaling and homeostasis through the oxidation of protein thiols. However, the dynamic…”
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Coping with Loss: Cell Adaptation to Cytoskeleton Disruption
Published in Developmental cell (10-10-2016)“…Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan…”
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Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver
Published in Biochemical journal (01-07-2015)“…Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and…”
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Rho GTPases: Non‐canonical regulation by cysteine oxidation
Published in BioEssays (01-02-2022)“…Rho GTPases are critically important and are centrally positioned regulators of the actomyosin cytoskeleton. By influencing the organization and architecture…”
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MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours
Published in Cancer letters (28-10-2021)“…The Molecule Interacting with CasL 1 (MICAL1) monooxygenase has emerged as an important regulator of cytoskeleton organization via actin oxidation. Although…”
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Mical1 deletion in tyrosinase expressing cells affects mouse running gaits
Published in Genes, brain and behavior (01-10-2024)“…Neuronal development is a highly regulated process that is dependent on the correct coordination of cellular responses to extracellular cues. In response to…”
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Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
Published in Journal of cell science (31-05-2019)“…Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression…”
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Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity
Published in The Journal of pharmacology and experimental therapeutics (01-11-2015)“…Acetaminophen (APAP) is the most commonly used over-the-counter analgesic. However, hepatotoxicity induced by APAP is a major clinical issue, and the factors…”
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Organotypic platform for studying cancer cell metastasis
Published in Experimental cell research (15-04-2021)“…Metastasis is the leading cause of mortality in cancer patients. To migrate to distant sites, cancer cells would need to adapt their behaviour in response to…”
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
Published in EMBO molecular medicine (07-03-2022)“…Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal…”
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Removal notice to “Non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection” [Toxicology 290 (2011) 130]
Published in Toxicology (Amsterdam) (16-12-2012)Get full text
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REMOVED: Non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection
Published in Toxicology (Amsterdam) (2011)“…This article has been removed: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been…”
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Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection
Published in Toxicology (Amsterdam) (2010)Get full text
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Non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection
Published in Toxicology (Amsterdam) (2011)Get full text
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