Search Results - "McGargill, Maureen A"

Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function by Rezinciuc, Svetlana, Bezavada, Lavanya, Bahadoran, Azadeh, Duan, Susu, Wang, Ruoning, Lopez-Ferrer, Daniel, Finkelstein, David, McGargill, Maureen A, Green, Douglas R, Pasa-Tolic, Ljiljana, Smallwood, Heather S

“…Infection with the influenza virus triggers an innate immune response that initiates the adaptive response to halt viral replication and spread. However, the…”
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Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2 by Hertz, Tomer, Levy, Shlomia, Ostrovsky, Daniel, Oppenheimer, Hanna, Zismanov, Shosh, Kuzmina, Alona, Friedman, Lilach M., Trifkovic, Sanja, Brice, David, Chun-Yang, Lin, Cohen-Lavi, Liel, Shemer-Avni, Yonat, Cohen-Lahav, Merav, Amichay, Doron, Keren-Naus, Ayelet, Voloshin, Olga, Weber, Gabriel, Najjar-Debbiny, Ronza, Chazan, Bibiana, McGargill, Maureen A., Webby, Richard, Chowers, Michal, Novack, Lena, Novack, Victor, Taube, Ran, Nesher, Lior, Weinstein, Orly

“…Vaccination, especially with multiple doses, provides substantial population-level protection against COVID-19, but emerging variants of concern (VOC) and…”
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TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation by Anand, Paras K., Tait, Stephen W.G., Lamkanfi, Mohamed, Amer, Amal O., Nunez, Gabriel, Pagès, Gilles, Pouysségur, Jacques, McGargill, Maureen A., Green, Douglas R., Kanneganti, Thirumala-Devi

“…Listeria monocytogenes is a facultative intracellular pathogen that invades both phagocytic and non-phagocytic cells. Recent studies have shown that L…”
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Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis by Shaw, Patrick J, Lukens, John R, Burns, Samir, Chi, Hongbo, McGargill, Maureen A, Kanneganti, Thirumala-Devi

“…Multiple sclerosis is an autoimmune disease in which self-reactive T cells attack oligodendrocytes that myelinate axons in the CNS. Experimental autoimmune…”
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Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway by Pillai, Meenu R, Mihi, Belgacem, Ishiwata, Kenji, Nakamura, Kiminori, Sakuragi, Naoya, Finkelstein, David B, McGargill, Maureen A, Nakayama, Toshinori, Ayabe, Tokiyoshi, Coleman, Mathew L, Bix, Mark

“…Expulsion of parasitic gastrointestinal nematodes requires diverse effector mechanisms coordinated by a Th2-type response. The evolutionarily conserved JmjC…”
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Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity by Shaw, Patrick J., Barr, Maggie J., Lukens, John R., McGargill, Maureen A., Chi, Hongbo, Mak, Tak W., Kanneganti, Thirumala-Devi

“…Peripheral peptidolgycan (PGN) is present within antigen-presenting cells in the central nervous system (CNS) of multiple sclerosis (MS) patients, possibly…”
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Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2 by Roubidoux, Ericka Kirkpatrick, Brigleb, Pamela H., Vegesana, Kasi, Souquette, Aisha, Whitt, Kendall, Freiden, Pamela, Green, Amanda, Thomas, Paul G., McGargill, Maureen A., Wolf, Joshua, Schultz-Cherry, Stacey

“…SARS-CoV-2 has caused millions of infections worldwide since its emergence in 2019. Understanding how infection and vaccination induce mucosal immune responses…”
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DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development by Mandarano, Alexandra H., Harris, Tarsha L., Creasy, Blaine M., Wehenkel, Marie, Duggar, Marygrace, Wilander, Benjamin A., Mishra, Ashutosh, Crawford, Jeremy Chase, Mullen, Sarah A., Williams, Katherine M., Pillai, Meenu, High, Anthony A., McGargill, Maureen A.

“…Drak2-deficient (Drak2−/−) mice are resistant to multiple models of autoimmunity yet effectively eliminate pathogens and tumors. Thus, DRAK2 represents a…”
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Drak2 Does Not Regulate TGF-β Signaling in T Cells by Harris, Tarsha L, McGargill, Maureen A

“…Drak2 is a serine/threonine kinase expressed highest in T cells and B cells. Drak2-/- mice are resistant to autoimmunity in mouse models of type 1 diabetes and…”
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Broadly Reactive Influenza Antibodies Are Not Limited by Germinal Center Competition with High-Affinity Antibodies by Keating, Rachael, Johnson, Jenny L, Brice, David C, Labombarde, Jocelyn G, Dent, Alexander L, McGargill, Maureen A

“…Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While…”
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Induction of broadly reactive influenza antibodies increases susceptibility to autoimmunity by Labombarde, Jocelyn G., Pillai, Meenu R., Wehenkel, Marie, Lin, Chun-Yang, Keating, Rachael, Brown, Scott A., Crawford, Jeremy Chase, Brice, David C., Castellaw, Ashley H., Mandarano, Alexandra H., Guy, Clifford S., Mejia, Juan R., Lewis, Carlessia D., Chang, Ti-Cheng, Oshansky, Christine M., Wong, Sook-San, Webby, Richard J., Yan, Mei, Li, Quan–Zhen, Marion, Tony N., Thomas, Paul G., McGargill, Maureen A.

“…Infection and vaccination repeatedly expose individuals to antigens that are conserved between influenza virus subtypes. Nevertheless, antibodies recognizing…”
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Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7 by Hayashi, Tomoko, Gray, Christine S, Chan, Michael, Tawatao, Rommel I, Ronacher, Lisa, McGargill, Maureen A, Datta, Sandip K, Carson, Dennis A, Corr, Maripat

“…Activation of Toll-like receptors (TLR) contributes to the initiation and maintenance of chronic inflammation in autoimmune diseases, yet repeated exposure to…”
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An Assessment of Serological Assays for SARS-CoV-2 as Surrogates for Authentic Virus Neutralization by Wohlgemuth, Nicholas, Whitt, Kendall, Cherry, Sean, Kirkpatrick Roubidoux, Ericka, Lin, Chun-Yang, Allison, Kim J, Gowen, Ashleigh, Freiden, Pamela, Allen, E. Kaitlynn, Gaur, Aditya H, Estepp, Jeremie H, Tang, Li, Mori, Tomi, Hijano, Diego R, Hakim, Hana, McGargill, Maureen A, Krammer, Florian, Whitt, Michael A, Wolf, Joshua, Thomas, Paul G, Schultz-Cherry, Stacey

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic resulting in millions of cases and…”
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Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas by Wehenkel, Marie, Corr, Maripat, Guy, Clifford S, Edwards, Benjamin A, Castellaw, Ashley H, Calabrese, Christopher, Pagès, Gilles, Pouysségur, Jacques, Vogel, Peter, McGargill, Maureen A

“…Defects in cartilage homeostasis can give rise to various skeletal disorders including osteochondromas. Osteochondromas are benign bone tumors caused by excess…”
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Drak2 is not required for tumor surveillance and suppression by Edwards, Benjamin A, Harris, Tarsha L, Floersh, Helen, Lukens, John R, Zaki, Md Hasan, Vogel, Peter, Kanneganti, Thirumala-Devi, Bui, Jack D, McGargill, Maureen A

“…Drak2 is a promising therapeutic target to treat organ-specific autoimmune diseases such as type 1 diabetes and multiple sclerosis without causing generalized…”
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SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells by Minervina, Anastasia A., Pogorelyy, Mikhail V., Kirk, Allison M., Crawford, Jeremy Chase, Allen, E. Kaitlynn, Chou, Ching-Heng, Mettelman, Robert C., Allison, Kim J., Lin, Chun-Yang, Brice, David C., Zhu, Xun, Vegesana, Kasi, Wu, Gang, Trivedi, Sanchit, Kottapalli, Pratibha, Darnell, Daniel, McNeely, Suzanne, Olsen, Scott R., Schultz-Cherry, Stacey, Estepp, Jeremie H., McGargill, Maureen A., Wolf, Joshua, Thomas, Paul G.

“…Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects…”
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The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus by Keating, Rachael, Hertz, Tomer, Wehenkel, Marie, Harris, Tarsha L, Edwards, Benjamin A, McClaren, Jennifer L, Brown, Scott A, Surman, Sherri, Wilson, Zachary S, Bradley, Philip, Hurwitz, Julia, Chi, Hongbo, Doherty, Peter C, Thomas, Paul G, McGargill, Maureen A

“…Influenza viruses are highly variable, which complicates vaccine strategies to protect against emerging viruses. McGargill and colleagues show that blocking…”
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Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response by Lin, Chun-Yang, Wolf, Joshua, Brice, David C., Sun, Yilun, Locke, Macauley, Cherry, Sean, Castellaw, Ashley H., Wehenkel, Marie, Crawford, Jeremy Chase, Zarnitsyna, Veronika I., Duque, Daniel, Allison, Kim J., Allen, E. Kaitlynn, Brown, Scott A., Mandarano, Alexandra H., Estepp, Jeremie H., Gaur, Aditya H., Hoffman, James M., Mori, Tomi, Tuomanen, Elaine I., Webby, Richard J., Hakim, Hana, Hayden, Randall T., Hijano, Diego R., Awad, Walid, Bajracharya, Resha, Clark, Brandi L., Cortez, Valerie, Dallas, Ronald H., Fabrizio, Thomas, Freiden, Pamela, Gowen, Ashleigh, Hodges, Jason, Kirk, Allison M., Roubidoux, Ericka Kirkpatrick, Mettelman, Robert C., Russell-Bell, Jamie, Souquette, Aisha, Sparks, James, Van de Velde, Lee-Ann, Vazquez-Pagan, Ana, Whitt, Kendall, Wilson, Taylor L., Wittman, David E., Wohlgemuth, Nicholas, Wu, Gang, Taylor, Charles, Molina-Paris, Carmen, Schultz-Cherry, Stacey, Tang, Li, Thomas, Paul G., McGargill, Maureen A.

“…SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether…”
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Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes by Abdelsamed, Hossam A., Zebley, Caitlin C., Nguyen, Hai, Rutishauser, Rachel L., Fan, Yiping, Ghoneim, Hazem E., Crawford, Jeremy Chase, Alfei, Francesca, Alli, Shanta, Ribeiro, Susan Pereira, Castellaw, Ashley H., McGargill, Maureen A., Jin, Hongjian, Boi, Shannon K., Speake, Cate, Serti, Elisavet, Turka, Laurence A., Busch, Michael E., Stone, Mars, Deeks, Steven G., Sekaly, Rafick-Pierre, Zehn, Dietmar, James, Eddie A., Nepom, Gerald T., Youngblood, Ben

“…The pool of beta cell-specific CD8 + T cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen…”
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Foxo Transcription Factors Control Regulatory T Cell Development and Function by Kerdiles, Yann M., Stone, Erica L., Beisner, Daniel L., McGargill, Maureen A., Ch'en, Irene L., Stockmann, Christian, Katayama, Carol D., Hedrick, Stephen M.

“…Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid…”
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