Search Results - "McGann, Locksley E."

Mesenchymal stromal cells derived from various tissues: Biological, clinical and cryopreservation aspects by Marquez-Curtis, Leah A., Janowska-Wieczorek, Anna, McGann, Locksley E., Elliott, Janet A.W.

“…Originally isolated from bone marrow, mesenchymal stromal cells (MSCs) have since been obtained from various fetal and post-natal tissues and are the focus of…”
Get full text

Cryopreservation of human cerebral microvascular endothelial cells and astrocytes in suspension and monolayers by Marquez-Curtis, Leah A, Bokenfohr, Reid, McGann, Locksley E, Elliott, Janet A W

“…The blood-brain barrier (BBB) keeps pathogens and toxins out of the brain but also impedes the entry of pharmaceuticals. Human cerebral microvascular…”
Get full text

Cryopreservation of human umbilical vein and porcine corneal endothelial cell monolayers by Eskandari, Nasim, Marquez-Curtis, Leah A., McGann, Locksley E., Elliott, Janet A.W.

“…Cryopreservation of endothelium is one of the major challenges in the cryopreservation of complex tissues. Human umbilical vein endothelial cells (HUVECs) in…”
Get full text

Cryopreservation and post-thaw characterization of dissociated human islet cells by Marquez-Curtis, Leah A, Dai, Xiao-Qing, Hang, Yan, Lam, Jonathan Y, Lyon, James, Manning Fox, Jocelyn E, McGann, Locksley E, MacDonald, Patrick E, Kim, Seung K, Elliott, Janet A W

“…The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell…”
Get full text

Improved Cryopreservation of Human Umbilical Vein Endothelial Cells: A Systematic Approach by Sultani, A. Billal, Marquez-Curtis, Leah A., Elliott, Janet A. W., McGann, Locksley E.

“…Cryopreservation of human umbilical vein endothelial cells (HUVECs) facilitated their commercial availability for use in vascular biology, tissue engineering…”
Get full text

Osmotic Transport across Cell Membranes in Nondilute Solutions: A New Nondilute Solute Transport Equation by Elmoazzen, Heidi Y., Elliott, Janet A.W., McGann, Locksley E.

“…The fundamental physical mechanisms of water and solute transport across cell membranes have long been studied in the field of cell membrane biophysics…”
Get full text

Expansion and cryopreservation of porcine and human corneal endothelial cells by Marquez-Curtis, Leah A., McGann, Locksley E., Elliott, Janet A.W.

“…Impairment of the corneal endothelium causes blindness that afflicts millions worldwide and constitutes the most often cited indication for corneal…”
Get full text

Transport Phenomena in Articular Cartilage Cryopreservation as Predicted by the Modified Triphasic Model and the Effect of Natural Inhomogeneities by Abazari, Alireza, Thompson, Richard B., Elliott, Janet A.W., McGann, Locksley E.

“…Knowledge of the spatial and temporal distribution of cryoprotective agent (CPA) is necessary for the cryopreservation of articular cartilage. Cartilage…”
Get full text

Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches by Lehr, Eric J., MD, PhD, Rayat, Gina R., PhD, Chiu, Brian, MD, Churchill, Thomas, PhD, McGann, Locksley E., PhD, Coe, James Y., MD, Ross, David B., MD

“…Objectives Allograft vascular tissue is important in the repair of complex structural lesions of the heart and great vessels, but induces a deleterious immune…”
Get full text

Effect of supercooling and cell volume on intracellular ice formation by Prickett, Richelle C., Marquez-Curtis, Leah A., Elliott, Janet A.W., McGann, Locksley E.

“…Intracellular ice formation (IIF) has been linked to death of cells cryopreserved in suspension. It has been assumed that cells can be supercooled by 2 to 10°C…”
Get full text

Cryopreserved amniotic membrane as transplant allograft: viability and post-transplant outcome by Perepelkin, Natasha M. J., Hayward, Kirsten, Mokoena, Tumelo, Bentley, Michael J., Ross-Rodriguez, Lisa U., Marquez-Curtis, Leah, McGann, Locksley E., Holovati, Jelena L., Elliott, Janet A. W.

“…Amniotic membrane (AM) transplantation is increasingly used in ophthalmological and dermatological surgeries to promote re-epithelialization and wound healing…”
Get full text

Intercellular Ice Propagation: Experimental Evidence for Ice Growth through Membrane Pores by Acker, Jason P., Elliott, Janet A.W., McGann, Locksley E.

“…Propagation of intracellular ice between cells significantly increases the prevalence of intracellular ice in confluent monolayers and tissues. It has been…”
Get full text

Permeability and Osmotic Parameters of Human Umbilical Vein Endothelial Cells and H9C2 Cells under Non-ideal Thermodynamic Assumptions: A Novel Iterative Fitting Method by Gabler Pizarro, Laura A., McGann, Locksley E., Elliott, Janet A. W.

“…Cryopreservation is the use of very low subzero temperatures to preserve cells and tissues for later use. This is achieved by controlled cooling in the…”
Get full text

Protocol for Cryopreservation of Endothelial Monolayers by Marquez-Curtis, Leah A, Eskandari, Nasim, McGann, Locksley E, Elliott, Janet A W

“…One of the major challenges in the preservation of complex tissues is the cryosensitivity of the endothelium, the single layer of cells lining blood vessels,…”
Get more information

Cryopreservation of porcine articular cartilage: MRI and biochemical results after different freezing protocols by Laouar, Leila, Fishbein, Ken, McGann, Locksley E., Horton, Walter E., Spencer, Richard G., Jomha, Nadr M.

“…The objective of this study was to investigate the effects of cryopreservation on the components of articular cartilage (AC) matrix by utilizing magnetic…”
Get full text

Nonideal Solute Chemical Potential Equation and the Validity of the Grouped Solute Approach for Intracellular Solution Thermodynamics by Zielinski, Michal W, McGann, Locksley E, Nychka, John A, Elliott, Janet A. W

“…The prediction of nonideal chemical potentials in aqueous solutions is important in fields such as cryobiology, where models of water and solute transportthat…”
Get full text

Measurement of grouped intracellular solute osmotic virial coefficients by Zielinski, Michal W., McGann, Locksley E., Nychka, John A., Elliott, Janet A.W.

“…Models of cellular osmotic behaviour depend on thermodynamic solution theories to calculate chemical potentials in the solutions inside and outside the cell…”
Get full text

Cryopreservation of articular cartilage by Abazari, Alireza, Jomha, Nadr M., Elliott, Janet A.W., McGann, Locksley E.

“…Cryopreservation has numerous practical applications in medicine, biotechnology, agriculture, forestry, aquaculture and biodiversity conservation, with huge…”
Get full text

Thermal expansion of substrate may affect adhesion of Chinese hamster fibroblasts to surfaces during freezing by Rutt, Taylor, Eskandari, Nasim, Zhurova, Maria, Elliott, Janet A.W., McGann, Locksley E., Acker, Jason P., Nychka, John A.

“…Despite success in cryopreservation of cells in suspension, cryopreservation of cells in monolayers is still challenging. One of the major problems is…”
Get full text

Vitrification of intact human articular cartilage by Jomha, Nadr M, Elliott, Janet A.W, Law, Garson K, Maghdoori, Babak, Fraser Forbes, J, Abazari, Alireza, Adesida, Adetola B, Laouar, Leila, Zhou, Xianpei, McGann, Locksley E

“…Abstract Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral…”
Get full text