Search Results - "McGann, James C"

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome by Garg, Saurabh K, Lioy, Daniel T, Cheval, Hélène, McGann, James C, Bissonnette, John M, Murtha, Matthew J, Foust, Kevin D, Kaspar, Brian K, Bird, Adrian, Mandel, Gail

“…De novo mutations in the X-linked gene encoding the transcription factor methyl-CpG binding protein 2 (MECP2) are the most frequent cause of the neurological…”
Get full text

Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype by McGann, James C, Oyer, Jon A, Garg, Saurabh, Yao, Huilan, Liu, Jun, Feng, Xin, Liao, Lujian, Yates, 3rd, John R, Mandel, Gail

“…The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the…”
Get full text

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis by Olive, Virginie, Sabio, Erich, Bennett, Margaux J, De Jong, Caitlin S, Biton, Anne, McGann, James C, Greaney, Samantha K, Sodir, Nicole M, Zhou, Alicia Y, Balakrishnan, Asha, Foth, Mona, Luftig, Micah A, Goga, Andrei, Speed, Terence P, Xuan, Zhenyu, Evan, Gerard I, Wan, Ying, Minella, Alex C, He, Lin

“…mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt's lymphoma model, mir-17-92…”
Get full text

Neuronal activity induces glutathione metabolism gene expression in astrocytes by McGann, James C., Mandel, Gail

“…The idea that astrocytes provide support for neurons has a long history, but whether neurons play an instructive role in these processes is poorly understood…”
Get full text

The Genome-Wide Binding Profile for Human RE1 Silencing Transcription Factor Unveils a Unique Genetic Circuitry in Hippocampus by McGann, James C, Spinner, Michael A, Garg, Saurabh K, Mullendorff, Karin A, Woltjer, Randall L, Mandel, Gail

“…Early studies in mouse neurodevelopment led to the discovery of the RE1 Silencing Transcription Factor (REST) and its role as a master repressor of neuronal…”
Get full text

Astrocytes conspire with neurons during progression of neurological disease by McGann, James C, Lioy, Daniel T, Mandel, Gail

“…Highlights ► Astrocytes have fundamental roles in neurological disease progression. ► In RTT and PD, astrocytes can independently cause disease phenotypes. ►…”
Get full text

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling by Huang, XiaoDong, McGann, James C., Liu, Bob Y., Hannoush, Rami N., Lill, Jennie R., Pham, Victoria, Newton, Kim, Kakunda, Michael, Liu, Jinfeng, Yu, Christine, Hymowitz, Sarah G., Hongo, Jo-Anne, Wynshaw-Boris, Anthony, Polakis, Paul, Harland, Richard M., Dixit, Vishva M.

“…Receptor-interacting protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Papas syndrome. RIPK4 binds to protein…”
Get full text

RIPK4 phosphorylates Dishevelled proteins to regulate canonical Wnt signaling by Huang, XiaoDong, McGann, James C., Liu, Bob Y., Hannoush, Rami N., Lill, Jennie R., Pham, Victoria, Newton, Kim, Kakunda, Michael, Liu, Jinfeng, Yu, Christine, Hymowitz, Sarah G., Hongo, Jo-Anne, Wynshaw-Boris, Anthony, Polakis, Paul, Harland, Richard M., Dixit, Vishva M.

“…Receptor interacting protein kinase 4 (RIPK4) is required for epidermal differentiation ( 1 – 4 ) and is mutated in Bartsocas-Papas syndrome ( 5 , 6 ). While…”
Get full text