Search Results - "McFie, J."

The monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells by McFie, Pamela J., Patel, Apurv, Stone, Scot J.

“…The monoacylglycerol acyltransferase (MGAT) pathway has a well-established role in the small intestine where it facilitates the absorption of dietary fat. In…”
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Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum by McFie, Pamela J., Banman, Shanna L., Kary, Steven, Stone, Scot J.

“…Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by two distinct acyl-CoA:diacylglycerol acyltransferase…”
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Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation by McFie, Pamela J., Stone, Sandra L., Banman, Shanna L., Stone, Scot J.

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) is an integral membrane protein of the endoplasmic reticulum that catalyzes the synthesis of triacylglycerols…”
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A fluorescent assay to quantitatively measure in vitro acyl CoA:diacylglycerol acyltransferase activity by McFie, Pamela J., Stone, Scot J.

“…Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase…”
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Identification of calnexin as a diacylglycerol acyltransferase-2 interacting protein by Brandt, Curtis, McFie, Pamela J, Vu, Huyen, Chumala, Paulos, Katselis, George S, Stone, Scot J

“…Triacylglycerol synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferase-2 (DGAT2). DGAT2 is an integral membrane protein that is localized to the…”
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The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis by Hlynialuk, Christopher J., Ling, Binbing, Baker, Zakery N., Cobine, Paul A., Yu, Lisa D., Boulet, Aren, Wai, Timothy, Hossain, Amzad, El Zawily, Amr M., McFie, Pamela J., Stone, Scot J., Diaz, Francisca, Moraes, Carlos T., Viswanathan, Deepa, Petris, Michael J., Leary, Scot C.

“…Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic…”
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Diacylglycerol acyltransferase-2 contains a c-terminal sequence that interacts with lipid droplets by McFie, Pamela J., Banman, Shanna L., Stone, Scot J.

“…Diacylglycerol acyltranferase-2 (DGAT2) is a resident protein of the endoplasmic reticulum that catalyzes the synthesis of triacylglycerol. When lipid droplet…”
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DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells by McFie, Pamela J., Chumala, Paulos, Katselis, George S., Stone, Scot J.

“…In eukaryotic organisms, two unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, catalyze the final step of the triacylglycerol…”
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Diacylglycerol Acyltransferase-2 (DGAT2) and Monoacylglycerol Acyltransferase-2 (MGAT2) Interact to Promote Triacylglycerol Synthesis by Jin, Youzhi, McFie, Pamela J., Banman, Shanna L., Brandt, Curtis, Stone, Scot J.

“…Acyl CoA:1,2-diacylglycerol acyltransferase (DGAT)-2 is an integral membrane protein that catalyzes triacylglycerol (TG) synthesis using diacylglycerol and…”
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Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3) by Brandt, Curtis, McFie, Pamela J., Stone, Scot J.

“…MGAT3 catalyzes the synthesis of 1,2-diacylglycerol from 2-monoacylglycerol in an acyl CoA-dependent reaction. Although initially identified as an MGAT enzyme,…”
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Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome by Brandt, Curtis, McFie, Pamela J, Stone, Scot J

“…Acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT)-2 is one of the two DGAT enzymes that catalyzes the synthesis of triacylglycerol, which is an important form…”
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Endoplasmic reticulum-mitochondrial interaction mediated by mitofusin-1 or mitofusin-2 is not required for lipid droplet formation or adipocyte differentiation by McFie, Pamela J., Ambilwade, Prashant, Vu, Huyen, Stone, Scot J.

“…Organelles in cells physically interact with each other. Specifically, the interaction of ER and mitochondria has been shown to be important for transporting…”
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Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lipid precursors within the microsomal lumen by Qin, Wen, Sundaram, Meenakshi, Wang, Yuwei, Zhou, Hu, Zhong, Shumei, Chang, Chia-Ching, Manhas, Sanjay, Yao, Erik F, Parks, Robin J, McFie, Pamela J, Stone, Scot J, Jiang, Zhenghui G, Wang, Congrong, Figeys, Daniel, Jia, Weiping, Yao, Zemin

“…Hepatic assembly of triacylglycerol (TAG)-rich very low density lipoproteins (VLDL) is achieved through recruitment of bulk TAG (presumably in the form of…”
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Different Transcription Factor Binding Arrays Modulate the cAMP Responsivity of the Phosphoenolpyruvate Carboxykinase Gene Promoter by Wilson, Heather L, McFie, Pamela J, Roesler, William J

“…The cAMP responsiveness of the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter is mediated by a cAMP response unit, which includes three…”
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Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes by Davies, Gerald F, McFie, Pamela J, Khandelwal, Ramji L, Roesler, William J

“…Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear receptor that is activated by the binding of an appropriate ligand. Several studies…”
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Characterization of the interaction of diacylglycerol acyltransferase-2 with the endoplasmic reticulum and lipid droplets by McFie, Pamela J., Jin, Youzhi, Banman, Shanna L., Beauchamp, Erwan, Berthiaume, Luc G., Stone, Scot J.

“…Acyl CoA:diacylglycerol acyltransferase-2 (DGAT2) is an integral membrane protein that catalyzes the synthesis of triacylglycerol (TG). DGAT2 is present in the…”
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Membrane topology of human monoacylglycerol acyltransferase-2 and identification of regions important for its localization to the endoplasmic reticulum by McFie, Pamela J., Izzard, Sabrina, Vu, Huyen, Jin, Youzhi, Beauchamp, Erwan, Berthiaume, Luc G., Stone, Scot J.

“…Acyl CoA:2-monoacylglycerol acyltransferase (MGAT)-2 has an important role in dietary fat absorption in the intestine. MGAT2 resides in the endoplasmic…”
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The cAMP Response Element Binding Protein Synergizes with Other Transcription Factors to Mediate cAMP Responsiveness (∗) by Roesler, William J., Graham, Janet G., Kolen, Richard, Klemm, Dwight J., McFie, Pamela J.

“…The cAMP responsiveness of the promoter for phosphoenolpyruvate carboxykinase (EC 4.1.1.32) is mediated by a synergistic interaction between a complex…”
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Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins by Qin, Wen, Sundaram, Meenakshi, Wang, Yuwei, Zhou, Hu, Zhong, Shumei, Chang, Chia-Ching, Manhas, Sanjay, Yao, Erik F., Parks, Robin J., McFie, Pamela J., Stone, Scot J., Jiang, Zhenghui G., Wang, Congrong, Figeys, Daniel, Jia, Weiping, Yao, Zemin

“…Hepatic assembly of triacylglycerol (TAG)-rich very low density lipoproteins (VLDL) is achieved through recruitment of bulk TAG (presumably in the form of…”
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Characterization of CCAAT/Enhancer-binding Protein α as a Cyclic AMP-responsive Nuclear Regulator by Roesler, William J., Park, Edwards A., McFie, Pamela J.

“…The α isoform of CCAAT/enhancer-binding protein (C/EBPα) is a transcription factor that regulates expression of genes linked to adipose differentiation and…”
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