Search Results - "McFarlin, DE"

Immunological Aspects of Demyelinating Diseases by Martin, Roland, McFarland, Henry F, McFarlin, Dale E

“…Primary demyelination in the central nervous system results from damage to the myelin sheath or oligodendroglia and can be produced by a variety of mechanisms,…”
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Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis by Katz, D, Taubenberger, J K, Cannella, B, McFarlin, D E, Raine, C S, McFarland, H F

“…Magnetic resonance imaging is a highly sensitive method for the detection of the lesions of multiple sclerosis and renders possible the study and the evolution…”
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Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course by Racke, MK, Burnett, D, Pak, SH, Albert, PS, Cannella, B, Raine, CS, McFarlin, DE, Scott, DE

“…Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by central nervous system inflammation and demyelination. Retinoids…”
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Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1 by Racke, MK, Dhib-Jalbut, S, Cannella, B, Albert, PS, Raine, CS, McFarlin, DE

“…Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system. The…”
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Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis by McFarland, H F, Frank, J A, Albert, P S, Smith, M E, Martin, R, Harris, J O, Patronas, N, Maloni, H, McFarlin, D E

“…The highly variable clinical course and the lack of a direct measurement of disease activity have made evaluation of experimental therapies in multiple…”
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Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions by Smith, M E, Stone, L A, Albert, P S, Frank, J A, Martin, R, Armstrong, M, Maloni, H, McFarlin, D E, McFarland, H F

“…It is now well established that clinically stable patients with relapsing-remitting multiple sclerosis have ongoing disease activity when evaluated by serial…”
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Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history by Harris, J O, Frank, J A, Patronas, N, McFarlin, D E, McFarland, H F

“…Six patients with early, mild, relapsing-remitting multiple sclerosis were studied with monthly gadolinium-enhanced magnetic resonance imaging scans for 8 to…”
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Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals by Martin, R, Jaraquemada, D, Flerlage, M, Richert, J, Whitaker, J, Long, EO, McFarlin, DE, McFarland, HF

“…Myelin basic protein (MBP) is a candidate Ag for the autoimmune process believed to be involved in the pathogenesis of multiple sclerosis (MS). To investigate…”
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A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis by MARTIN, R, HOWELL, M. D, JARAQUEMADA, D, FLERLAGE, M, RICHERT, J, BROSTOFF, S, LONG, E. O, MCFARLIN, D. E, MCFARLAND, H. F

“…We have examined previously the peptide specificity of the T cell response to myelin basic protein (MBP) in patients with multiple sclerosis (MS) and healthy…”
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Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis by Jacobson, S, Lehky, T, Nishimura, M, Robinson, S, McFarlin, D E, Dhib-Jalbut, S

“…An increasing spectrum of diseases has been shown to be associated with the human T-cell lymphotropic virus type I (HTLV-I), most notably a chronic,…”
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Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis by Utz, Ursula, Biddison, William E, McFarland, Henry F, McFarlin, Dale E, Flerlage, Marjorie, Martin, Roland

“…Although the cause of multiple sclerosis (MS) is unknown, it is thought to involve a T cell-mediated autoimmune mechanism. Susceptibility to the disease is…”
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Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement by JACOBSON, D. R, MCFARLIN, D. E, KANE, I, BUXBAUM, J. N

“…Mutations in the protein transthyretin cause amyloidosis involving the heart, peripheral nerves, and other organs. A family from West Virginia developed an…”
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Evidence of endogenous regulatory function of transforming growth factor-beta 1 in experimental allergic encephalomyelitis by Racke, M K, Cannella, B, Albert, P, Sporn, M, Raine, C S, McFarlin, D E

“…Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS)…”
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Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes by Drew, PD, Lonergan, M, Goldstein, ME, Lampson, LA, Ozato, K, McFarlin, DE

“…MHC class I molecules are coexpressed with beta 2-microglobulin (beta 2-M) on many somatic cells. However, these proteins are normally not present on cells of…”
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Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells by McCarron, R M, Wang, L, Racke, M K, McFarlin, D E, Spatz, M

“…Adhesive interactions between murine cerebrovascular endothelial cells (EC) which comprise the blood-brain barrier (BBB) and myelin basic protein…”
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Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106 by Martin, R, Utz, U, Coligan, JE, Richert, JR, Flerlage, M, Robinson, E, Stone, R, Biddison, WE, McFarlin, DE, McFarland, HF

“…Multiple sclerosis (MS), a human demyelinating disease, is thought to be caused by an autoimmunologic process, and myelin basic protein (MBP) is considered a…”
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Cell type-specific regulation of major histocompatibility complex (MHC) class I gene expression in astrocytes, oligodendrocytes, and neurons by Massa, P T, Ozato, K, McFarlin, D E

“…Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures,…”
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Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 2 by Racke, M K, Sriram, S, Carlino, J, Cannella, B, Raine, C S, McFarlin, D E

“…It had been demonstrated previously that the administration of transforming growth factor-beta 1 (TGF-beta 1) reduced the clinical severity of experimental…”
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Changes in the amount of diseased white matter over time in patients with relapsing-remitting multiple sclerosis by STONE, L. A, ALBERT, P. S, SMITH, M. E, DECARLI, C, ARMSTRONG, M. R, MCFARLIN, D. E, FRANK, J. A, MCFARLAND, H. F

“…MRI is a sensitive technique for assessing disease activity in MS. Diseased white matter (WM) can be identified on T2-weighted images, and active disease is…”
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Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis by Jacobson, Steven, Raine, Cedric S, Mingioli, Elizabeth S, McFarlin, Dale E

“…Tropical spastic paraparesis (TSP) is a slowly progressive myelopathy associated with increased serum and cerebrospinal fluid antibodies to the human…”
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