Search Results - "McFARLAND, HUGH I."

NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes by Xu, Lai, Pelosof, Lorraine, Wang, Rong, McFarland, Hugh I, Wu, Wells W, Phue, Je-Nie, Lee, Chun-Ting, Shen, Rong-Fong, Juhl, Hartmut, Wu, Lei-Hong, Alterovitz, Wei-Lun, Petricon, Emanuel, Rosenberg, Amy S

“…To evaluate the expression of immune checkpoint genes, their concordance with expression of IFNγ, and to identify potential novel ICP related genes (ICPRG) in…”
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Regulatory T cells in γ irradiation-induced immune suppression by McFarland, Hugh I, Puig, Montserrat, Grajkowska, Lucja T, Tsuji, Kazuhide, Lee, Jay P, Mason, Karen P, Verthelyi, Daniela, Rosenberg, Amy S

“…Sublethal total body γ irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide…”
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Rescue of CD8+ T cell vaccine memory following sublethal γ irradiation by McFarland, Hugh I, Berkson, Julia D, Lee, Jay P, Elkahloun, Abdel G, Mason, Karen P, Rosenberg, Amy S

“…Highlights • Sublethal γ radiation impairs memory CD8+ T cell responses. • Revaccination during a short window after irradiation rescues vaccine memory. •…”
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Skin allograft rejection by McFarland, Hugh I, Rosenberg, Amy S

“…Skin allograft rejection is a test of the competence of T lymphocytes to mediate in vivo tissue destruction, which in turn reflects their role in critical…”
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Determinant Spreading Associated with Demyelination in a Nonhuman Primate Model of Multiple Sclerosis by McFarland, Hugh I, Lobito, Adrian A, Johnson, Michele M, Nyswaner, Jeffrey T, Frank, Joseph A, Palardy, Gregory R, Tresser, Nancy, Genain, Claude P, Mueller, John P, Matis, Louis A, Lenardo, Michael J

“…Definition of the immune process that causes demyelination in multiple sclerosis is essential to determine the feasibility of Ag-directed immunotherapy. Using…”
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Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR by McFarland, Hugh I., Hansal, Susan A., Morris, Diane I., McVicar, Daniel W., Love, Paul E., Rosenberg, Amy S.

“…We constructed a chimeric molecule, composed of the T-cell receptor (TCR)–ζ chain fused to the extracellular domains of a prototypical allogeneic major…”
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Development of a Therapeutic to Preserve Vaccine Memory Following Ionizing Radiation Exposure by Aryankalayil, Joseph B, McFarland, Hugh I, Rosenberg, Amy S

“…We have demonstrated that in a mouse model of Listeria monocytogenes (LM) infection, revaccination within 3 days after exposure to sub-lethal ionizing…”
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Rescue of vaccine immunity with nicotine and isoproterenol after total body irradiation by Gandhi, Deep, Lehtimaki, Mari K., Surujdin, Ryan, Aryankalyil, Joseph, McFarland, Hugh I., Rosenberg, Amy S.

“…Radiation exposure results in DNA damage and apoptosis of lymphocytes, including memory T cells, leading to the loss of vaccine immunity and resulting in a…”
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Serial MR Imaging of Experimental Autoimmune Encephalomyelitis Induced by Human White Matter or by Chimeric Myelin-Basic and Proteolipid Protein in the Common Marmoset by Jordan, E. Kay, McFarland, Hugh I, Lewis, Bobbi K, Tresser, Nancy, Gates, Michael A, Johnson, Michele, Lenardo, Michael, Matis, Louis A, McFarland, Henry F, Frank, Joseph A

“…Experimental autoimmune encephalomyelitis (EAE) in the marmoset was monitored by serial MR imaging to determine correlates to the natural-history MR studies in…”
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Effective Antigen-Specific Immunotherapy in the Marmoset Model of Multiple Sclerosis by McFarland, Hugh I, Lobito, Adrian A, Johnson, Michele M, Palardy, Gregory R, Yee, Christina S. K, Jordan, E. Kay, Frank, Joseph A, Tresser, Nancy, Genain, Claude P, Mueller, John P, Matis, Louis A, Lenardo, Michael J

“…Mature T cells initially respond to Ag by activation and expansion, but high and repeated doses of Ag cause programmed cell death and can suppress T…”
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Development of therapeutics to maintain vaccine immunity following exposure to ionizing radiation by McFarland, Hugh I, Surujdin, Ryan T, Aryankalayil, Joseph, Berkson, Julia D., Lee, Jay P., Rosenberg, Amy S.

“…Exposure to γ radiation from nuclear power plant disasters, terrorist acts, and medical procedures devastate the peripheral immune system, killing both naïve…”
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T cell receptor transgenic mice recognizing the immunodominant epitope of the Torpedo californica acetylcholine receptor by Lobito, Adrian A., Yang, Bingzhi, Lopes, Marcela F., Miagkov, Alexei, Adams, Robert N., Palardy, Gregory R., Johnson, Michele M., McFarland, Hugh I., Recher, Michael, Drachman, Daniel B., Lenardo, Michael J.

“…Myasthenia gravis (MG) is an autoimmune disease caused by T cell‐dependent antibody‐mediated reduction of acetylcholine receptors (AChR) at the neuromuscular…”
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Antigen Presentation Determines the Fate of the T Memory Response In Vivo After Sublethal Gamma-Irradiation by Sechler, Joan M. G, Hansal, Susan A, Morris, Diane I, McFarland, Hugh I, Rosenberg, Amy S

“…The survival of memory T cells is critical to vaccination strategies for infectious diseases and cancer, whereas their elimination may be crucial for treatment…”
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Rescue of CD8+ T cell vaccine memory following sublethal [gamma] irradiation by McFarland, Hugh I, Berkson, Julia D, Lee, Jay P, Elkahloun, Abdel G, Mason, Karen P, Rosenberg, Amy S

“…Sublethal γ irradiation eliminates CD8+ T cell mediated memory responses. In this work, we explored how these memory responses could be rescued in the…”
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Regulatory T Cells in [gamma] Irradiation-Induced Immune Suppression by McFarland, Hugh I, Puig, Montserrat, Grajkowska, Lucja T, Tsuji, Kazuhide, Lee, Jay P, Mason, Karen P, Verthelyi, Daniela, Rosenberg, Amy S

“…Sublethal total body [gamma] irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide…”
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CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection by McFarland, HI, Nahill, SR, Maciaszek, JW, Welsh, RM

“…We have found that CD11b, a cell surface integrin of macrophages, granulocytes, and NK cells, is expressed by a subset of CD8+ T cells that include both the…”
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In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice by Razvi, ES, Welsh, RM, McFarland, HI

“…The in vivo state of CD8+ mouse memory CTL specific to lymphocytic choriomeningitis virus (LCMV) was characterized. During acute LCMV infection, the majority…”
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Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein by Elliott, E A, McFarland, H I, Nye, S H, Cofiell, R, Wilson, T M, Wilkins, J A, Squinto, S P, Matis, L A, Mueller, J P

“…It has been shown that peripheral T cell tolerance can be induced by systemic antigen administration. We have been interested in using this phenomenon to…”
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Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor by MIAGKOV, ALEXEI, LOBITO, ADRIAN A., YANG, BINGZHI, LOPES, MARCELA F., ADAMS, ROBERT N., PALARDY, GREGORY R., JOHNSON, MICHELE M., McFARLAND, HUGH I., LENARDO, MICHAEL J., DRACHMAN, DANIEL B.

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Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells by McFarland, H I, Critchfield, J M, Racke, M K, Mueller, J P, Nye, S H, Boehme, S A, Lenardo, M J

“…We have shown that T cells vigorously cycling in response to growth lymphokines are driven into apoptosis by potent TCR restimulation. This process, termed…”
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