Search Results - "McEwen, B S"

Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant by Lau, T, Bigio, B, Zelli, D, McEwen, B S, Nasca, C

“…The adult brain is capable of adapting to internal and external stressors by undergoing structural plasticity, and failure to be resilient and preserve normal…”
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Psychosocial stress reversibly disrupts prefrontal processing and attentional control by Liston, C, McEwen, B.S, Casey, B.J

“…Relatively little is known about the long-term neurobiological sequelae of chronic stress, which predisposes susceptible patients to neuropsychiatric…”
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Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility by Nasca, C, Bigio, B, Zelli, D, Nicoletti, F, McEwen, B S

“…Why do some individuals succumb to stress and develop debilitating psychiatric disorders, whereas others adapt well in the face of adversity? There is a gap in…”
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Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory by Yuen, E Y, Liu, W, Karatsoreos, I N, Ren, Y, Feng, J, McEwen, B S, Yan, Z

“…Corticosteroid stress hormones have a strong impact on the function of prefrontal cortex (PFC), a central region controlling cognition and emotion, though the…”
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Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition by Wei, J, Yuen, E Y, Liu, W, Li, X, Zhong, P, Karatsoreos, I N, McEwen, B S, Yan, Z

“…Converging evidence suggests that females and males show different responses to stress; however, little is known about the mechanism underlying the sexually…”
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Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure by Hill, M N, Kumar, S A, Filipski, S B, Iverson, M, Stuhr, K L, Keith, J M, Cravatt, B F, Hillard, C J, Chattarji, S, McEwen, B S

“…Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like…”
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Lithium's role in neural plasticity and its implications for mood disorders by Gray, J. D., McEwen, B. S.

“…Objective Lithium (Li) is often an effective treatment for mood disorders, especially bipolar disorder (BPD), and can mitigate the effects of stress on the…”
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The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation by McEwen, B S, Chattarji, S, Diamond, D M, Jay, T M, Reagan, L P, Svenningsson, P, Fuchs, E

“…Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of…”
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Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors by Gray, J.D, Milner, T.A, McEwen, B.S

“…Highlights ► This review summarizes the effects of glucocorticoids and BDNF on neural plasticity. ► BDNF localization and activation of its receptors are…”
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Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery by Goldwater, D.S, Pavlides, C, Hunter, R.G, Bloss, E.B, Hof, P.R, McEwen, B.S, Morrison, J.H

“…Abstract Chronic stress has been shown in animal models to result in altered dendritic morphology of pyramidal neurons of the medial prefrontal cortex (mPFC)…”
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Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex by Radley, J.J, Sisti, H.M, Hao, J, Rocher, A.B, McCall, T, Hof, P.R, McEwen, B.S, Morrison, J.H

“…Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the negative feedback regulation of hypothalamic–pituitary–adrenal (HPA)…”
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Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine by MCEWEN, B. S, OLIE, J. P

“…Recent studies have provided evidence that structural remodeling of certain brain regions is a feature of depressive illness, and the postulated underlying…”
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CB1 receptor signaling regulates social anxiety and memory by Litvin, Y., Phan, A., Hill, M. N., Pfaff, D. W., McEwen, B. S.

“…The endocannabinoid (eCB) system regulates emotion, stress, memory and cognition through the cannabinoid type 1 (CB1) receptor. To test the role of CB1…”
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Allostasis and Allostatic Load: Implications for Neuropsychopharmacology by McEwen, Bruce S.

“…The primary hormonal mediators of the stress response, glucocorticoids and catecholamines, have both protective and damaging effects on the body. In the short…”
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Estrogen actions in the central nervous system by McEwen, B S, Alves, S E

“…This article will review the neural actions of estrogens in the central nervous system, focusing on brain structures outside of the hypothalamus and on…”
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Specific Regulatory Motifs Predict Glucocorticoid Responsiveness of Hippocampal Gene Expression by Datson, N. A, Polman, J. A. E, de Jonge, R. T, van Boheemen, P. T. M, van Maanen, E. M. T, Welten, J, McEwen, B. S, Meiland, H. C, Meijer, O. C

“…The glucocorticoid receptor (GR) is an ubiquitously expressed ligand-activated transcription factor that mediates effects of cortisol in relation to adaptation…”
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Stress and hippocampal plasticity by MCEWEN, B. S

“…The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain. It also responds to gonadal, thyroid, and…”
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Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice by Spencer, J.L, Waters, E.M, Milner, T.A, McEwen, B.S

“…Abstract Estradiol modulates dendritic spine morphology and synaptic protein expression in the rodent hippocampus, as well as hippocampal-dependent learning…”
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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala by Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.

“…Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and…”
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Protective and Damaging Effects of Stress Mediators by McEwen, Bruce S

“…Over 60 years ago, Selye 1 recognized the paradox that the physiologic systems activated by stress can not only protect and restore but also damage the body…”
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