Search Results - "McEwan, Jean R."

Primary care access plan means GP workload is likely to further increase by McEwan, Jean R

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Matrix Metalloproteinases and Cardiovascular Disease by Dollery, Clare M, McEwan, Jean R, Henney, Adriano M

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Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury by DOLLERY, C. M, HUMPHRIES, S. E, MCCLELLAND, A, LATCHMAN, D. S, MCEWAN, J. R

“…Cell migration is a major contributor to injury-induced neointimal hyperplasia and depends on alteration of the proteolytic balance within the arterial wall…”
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Cell electrospinning highly concentrated cellular suspensions containing primary living organisms into cell-bearing threads and scaffolds by Jayasinghe, Suwan N, Irvine, Scott, McEwan, Jean R

“…We recently pioneered the cell electrospinning of living cells as viable biological threads and scaffolds. In that study, we demonstrated the process with an…”
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novel direct aerodynamically assisted threading methodology for generating biologically viable microthreads encapsulating living primary cells by Arumuganathar, Sumathy, Irvine, Scott, McEwan, Jean R, Jayasinghe, Suwan N

“…In a recent discovery, coaxial electrospinning was explored to encapsulate living organisms within a continuous bio-polymeric microthread from which active…”
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Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury by Webb, Karen E, Henney, Adriano M, Anglin, Sandra, Humphries, Steve E, McEwan, Jean R

“…The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase…”
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TIMP-4 Is Regulated by Vascular Injury in Rats by Dollery, Clare M, McEwan, Jean R, Wang, Mingsheng, Sang, Qingxiang Amy, Liu, Yiliang E, Shi, Y. Eric

“…The role of basement membrane-degrading matrix metalloproteinases (MMPs) in enabling vascular smooth muscle cell migration after vascular injury has been…”
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Acute Depressed Mood as a Trigger of Acute Coronary Syndromes by Steptoe, Andrew, Strike, Philip C., Perkins-Porras, Linda, McEwan, Jean R., Whitehead, Daisy L.

“…Some cases of acute coronary syndrome (ACS) may be triggered by emotional states such as anger, but it is not known if acute depressed mood can act as a…”
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Bio-electrospraying embryonic stem cells: interrogating cellular viability and pluripotency by Abeyewickreme, Anil, Kwok, Albert, McEwan, Jean R, Jayasinghe, Suwan N

“…Bio-electrospraying, a recently discovered, direct electric field driven cell engineering process, has been demonstrated to have no harmful effects on treated…”
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Part-time working: full-time professionalism by McEwan, Jean R

“…This one-day conference brought together around 100 doctors from a wide range of specialties and at different stages of their careers to examine areas that are…”
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Inhibition of tissue angiotensin converting enzyme activity prevents malignant hypertension in TGR(mREN2)27 by Montgomery, Hugh E, Kiernan, Linda A, Whitworth, Caroline E, Fleming, Stewart, Unger, Thomas, Gohlke, Peter, Mullins, John J, McEwan, Jean R

“…BACKGROUNDActivation of the renin–angiotensin system has been implicated strongly in the transition from benign to malignant hypertension. However, the…”
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Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery disease by Strike, Philip C, Magid, Kesson, Brydon, Lena, Edwards, Susan, McEwan, Jean R, Steptoe, Andrew

“…This study compared the effects of acute mental stress on cardiovascular and subjective responses and platelet activation in male patients with established…”
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Aerodynamically assisted bio-jets: the development of a novel and direct non-electric field-driven methodology for engineering living organisms by Arumuganathar, Sumathy, Irvine, Scott, McEwan, Jean R, Jayasinghe, Suwan N

“…We recently demonstrated the ability to use electrified jets under stable conditions for the generation of cell-bearing droplets to the formation of composite…”
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An undiagnosed bicuspid aortic valve can result in severe left ventricular failure by Saha, Sagar, Bastiaenen, Rachel, Hayward, Martin, McEwan, Jean R

“…Asymptomatic bicuspid aortic valves diagnosed in childhood need regular monitoring to allow early surgical intervention and prevention of left ventricular…”
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Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training by MONTGOMERY, H. E, CLARKSON, P, WORLD, M, DEANFIELD, J, TALMUD, P, MCEWAN, J. R, MCKENNA, W. J, HUMPHRIES, S, DOLLERY, C. M, PRASAD, K, LOSI, M.-A, HEMINGWAY, H, STATTERS, D, JUBB, M, GIRVAIN, M, VARNAVA, A

“…The absence (deletion allele [D]) of a 287-base pair marker in the ACE gene is associated with higher ACE levels than its presence (insertion allele [I]). If…”
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Bio-electrosprays: A novel electrified jetting methodology for the safe handling and deployment of primary living organisms by Odenwälder, Patrick K., Irvine, Scott, McEwan, Jean R., Jayasinghe, Suwan N.

“…Electrohydrodynamic jetting (EHDJ) which is also known as electrosprays (ES) has recently been elucidated as a unique electrified biotechnique for the safe…”
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Pressure-assisted cell spinning: a direct protocol for spinning biologically viable cell-bearing fibres and scaffolds by Arumuganathar, Sumathy, Irvine, Scott, McEwan, Jean R, Jayasinghe, Suwan N

“…We recently pioneered the ability to directly electrospin living cells from which scaffolds to membranes were derived. This protocol, now widely referred to as…”
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Receptor-targeted Nanocomplexes optimized for Gene Transfer to Primary Vascular Cells and Explant Cultures of Rabbit Aorta by Irvine, Scott A, Meng, Qing-Hai, Afzal, Faiza, Ho, Jimmy, Wong, John B, Hailes, Helen C, Tabor, Alethea B, McEwan, Jean R, Hart, Stephen L

“…We have developed new, synthetic vector formulations that display high efficiency of gene transfer to vascular cells and tissues. The formulations comprise…”
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A hybrid bio-jetting approach for directly engineering living cells by Kwok, Albert, Arumuganathar, Sumathy, Irvine, Scott, McEwan, Jean R, Jayasinghe, Suwan N

“…This paper reports developments on a hybrid cell-engineering protocol coupling both bio-electrosprays and aerodynamically assisted bio-jets for…”
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Application to vascular adventitia of a nonviral vector for TIMP-1 gene therapy to prevent intimal hyperplasia by Meng, Qing-Hai, Jamal, Waheed, Hart, Stephen L, McEwan, Jean R

“…Somatic gene transfer continues to have potential for the study and therapy of cardiovascular disease. We have developed a modular, self-assembling, nonviral…”
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