Search Results - "McEvilly, Robert J."
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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
Published in Nature (15-11-2007)“…A series of transcription factors critical for maintenance of the neural stem cell state have been identified, but the role of functionally important…”
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2
Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis
Published in Nature neuroscience (01-11-2017)“…Long-range enhancer interactions regulate gene expression, yet how they influence CNS development and disease remains unclear. Glasgow et al . identified…”
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Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
Published in Development (Cambridge) (01-09-2008)“…Dlx transcription factors are implicated in patterning the mammalian jaw, based on their nested expression patterns in the first branchial arch (primordium for…”
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Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development
Published in Cell (15-09-2000)“…Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR…”
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Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors
Published in Science (American Association for the Advancement of Science) (22-02-2002)“…The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms…”
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Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development
Published in Nature (London) (13-06-1996)“…The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0…”
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Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
Published in Nature (London) (12-12-1996)“…Specific families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class…”
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Brn-3.0: A POU-Domain Protein Expressed in the Sensory, Immune, and Endocrine Systems that Functions on Elements Distinct from Known Octamer Motifs
Published in Proceedings of the National Academy of Sciences - PNAS (15-11-1993)“…Characterization of Brn-3.0 and identification of a highly related member (Brn-3.1) of the class IV POU-domain family suggest potential roles of Brn-3.0 in the…”
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A POU Domain Transcription Factor–Dependent Program Regulates Axon Pathfinding in the Vertebrate Visual System
Published in Neuron (Cambridge, Mass.) (01-12-2000)“…Axon pathfinding relies on the ability of the growth cone to detect and interpret guidance cues and to modulate cytoskeletal changes in response to these…”
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Interleukin-6 production by murine B cells and B cell lines
Published in Cellular immunology (01-02-1991)“…We have analyzed interleukin (IL)-6 gene transcription and IL-6 secretion by murine B cells in vitro. Mitogenic doses of lipopolysaccharide (LPS) or LPS in…”
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Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2
Published in Genes & development (15-12-1995)“…Neurons comprising the endocrine hypothalamus are disposed in several nuclei that develop in tandem with their ultimate target the pituitary gland, and arise…”
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Patterns of cytokine gene expression by CD4+ T cells from young and old mice
Published in The Journal of immunology (1950) (15-04-1993)“…We have analyzed the patterns of induced cytokine gene expression and cell cycle activity by CD4+ cells from mice, and have examined how these response…”
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Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation
Published in Genes & development (15-07-1997)“…Here we report on investigation of the role of the POU domain genes Skin-1a/i (Skn-1a/i/Epoc/Oct-11) and Testes-1 (Tst-1/Oct-6/SCIP) in epidermis where…”
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POU domain factors in neural development
Published in Advances in experimental medicine and biology (1998)“…Transcription factors serve critical roles in the progressive development of general body plan, organ commitment, and finally, specific cell types. Comparison…”
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Chromosomal organization of mammalian POU domain factors
Published in Genomics (San Diego, Calif.) (01-10-1993)“…We present the chromosomal locations in mouse of eight new members of the mammalian POU domain family of transcriptional regulators. Chromosomal assignments…”
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The role of POU domain proteins in the regulation of mammalian pituitary and nervous system development
Published in Progress in nucleic acid research and molecular biology (1999)“…POU domain proteins represent a subfamily of homeodomain-containing transcription factors that are expressed in many animal orders in a number of distinct…”
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