Search Results - "McElwee, Brooke"

The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance by Zou, Jianxuan, Jones, Richard J., Wang, Hua, Kuiatse, Isere, Shirazi, Fazal, Manasanch, Elisabet E., Lee, Hans C., Sullivan, Robert, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Hecht, David, Lam, Imelda, McElwee, Brooke, Chourasia, Aparajita H., Chan, Kyle W. H., Mercurio, Frank, Stirling, David I., Orlowski, Robert Z.

“…Small molecules targeting the cereblon-containing E3 ubiquitin ligase including thalidomide, lenalidomide, and pomalidomide modulate turnover of downstream…”
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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators by Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

“…Abstract BioTheryX's novel and unique Protein Homeostatic Modulators (PHMsTM) are small molecule “molecular glues” that promote ubiquitination of substrate…”
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Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies by Fung, Leah, Chourasia, Aparajita Hoskote, Torres, Eduardo, Lam, Imelda, Erdman, Paul, Hecht, David, Sullivan, Robert, McElwee, Brooke, Richard, Normand, Venkatachalam, Avanthika, Snir-Alkalay, Irit, Chan, Kyle WH, Mercurio, Frank, Ben-Neriah, Yinon, Stirling, David I

“…BioTheryx's small-molecule kinase inhibitor, BTX-A51 (the ditosylated salt of A51), has recently received FDA approval of its IND application to initiate a…”
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Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators by Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I

“…Targeting disease-relevant proteins by exploiting the cells' very own protein homeostasis machinery is the next generation drug discovery platform that has…”
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