Search Results - "McElroy, John F"

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance by Tam, Joseph, Cinar, Resat, Liu, Jie, Godlewski, Grzegorz, Wesley, Daniel, Jourdan, Tony, Szanda, Gergő, Mukhopadhyay, Bani, Chedester, Lee, Liow, Jeih-San, Innis, Robert B., Cheng, Kejun, Rice, Kenner C., Deschamps, Jeffrey R., Chorvat, Robert J., McElroy, John F., Kunos, George

“…Obesity-related leptin resistance manifests in loss of leptin’s ability to reduce appetite and increase energy expenditure. Obesity is also associated with…”
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Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test: Effects of Neurokinin-1 Receptor Antagonists by Wallace-Boone, Tanya L, Newton, Amy E, Wright, Robert N, Lodge, Nicholas J, McElroy, John F

“…Several studies have suggested that neurokinin-1 (NK1) receptor antagonists may have therapeutic potential as novel antidepressant drugs. To test these…”
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JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities by Chorvat, Robert J., Berbaum, Jennifer, Seriacki, Kristine, McElroy, John F.

“…Analogs of SLV-319 (Ibipinibant), a CB1 receptor inverse agonist, were synthesized with functionality intended to limit brain exposure while maintaining the…”
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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats by Lelas, Snjezana, Wong, Harvey, Li, Yu-Wen, Heman, Karen L, Ward, Kathryn A, Zeller, Kim L, Sieracki, Kristine K, Polino, Joseph L, Godonis, Helen E, Ren, Shelly X, Yan, Xiao-Xin, Arneric, Stephen P, Robertson, David W, Hartig, Paul R, Grossman, Scott, Trainor, George L, Taub, Rebecca A, Zaczek, Robert, Gilligan, Paul J, McElroy, John F

“…Corticotropin-releasing factor(1) (CRF(1)) antagonists may be effective in the treatment of anxiety disorders with fewer side effects compared with classic…”
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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists by Gilligan, Paul J, Clarke, Todd, He, Liqi, Lelas, Snjezana, Li, Yu-Wen, Heman, Karen, Fitzgerald, Lawrence, Miller, Keith, Zhang, Ge, Marshall, Anne, Krause, Carol, McElroy, John F, Ward, Kathyrn, Zeller, Kim, Wong, Harvey, Bai, Steven, Saye, Joanne, Grossman, Scott, Zaczek, Robert, Arneric, Stephen P, Hartig, Paul, Robertson, David, Trainor, George

“…This report describes the syntheses and structure−activity relationships of 8-(substituted pyridyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing…”
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The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats by MCELROY, John F, WARD, Kathryn A, ZELLER, Kim L, JONES, Keith W, GILLIGAN, Paul J, LIQI HE, LELAS, Sniezana

“…Abstract Rationale. CRF1 antagonists may be effective in the treatment of anxiety disorders while having fewer side effects compared with classical…”
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Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests by HOGAN, John B, HODGES, Donald B, LELAS, Snjezana, GILLIGAN, Paul J, MCELROY, John F, LINDNER, Mark D

“…Benzodiazepines continue to be widely used for the treatment of anxiety, but it is well known that benzodiazepines have undesirable side effects, including…”
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The anxiolytic CRF1 antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats by LELAS, Snjezana, ZELLER, Kim L, WARD, Kathryn A, MCELROY, John F

“…Rationale. Compounds with a mechanism of action different from benzodiazepines may retain the anxiolytic effects of benzodiazepines with fewer side effects…”
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Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics by TAEKYU LEE, ROBICHAUD, Albert J, BOYLE, Kristopher E, YIMIN LU, ROBERTSON, David W, MILLER, Keith J, FITZGERALD, Larry W, MCELROY, John F, LARGENT, Brian L

“…The discovery of N-substituted-pyridoindolines and their binding affinities at the 5-HT(2A), 5-HT(2C) and D(2) receptors, and in vivo efficacy as 5-HT(2A)…”
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Adverse Effects of Gabapentin and Lack of Anti-Allodynic Efficacy of Amitriptyline in the Streptozotocin Model of Painful Diabetic Neuropathy by Lindner, Mark D, Bourin, Clotilde, Chen, Ping, McElroy, John F, Leet, John E, Hogan, John B, Stock, David A, Machet, Frederic

“…Amitriptyline and gabapentin are the primary treatments for painful diabetic neuropathy (PDN), and it is clear that they produce beneficial effects, but there…”
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Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists by Dzierba, Carolyn D, Takvorian, Amy G, Rafalski, Maria, Kasireddy-Polam, Padmaja, Wong, Harvey, Molski, Thaddeus F, Zhang, Ge, Li, Yu-Wen, Lelas, Snjezana, Peng, Yong, McElroy, John F, Zaczek, Robert C, Taub, Rebecca A, Combs, Andrew P, Gilligan, Paul J, Trainor, George L

“…Corticotropin releasing factor (CRF) is the primary regulator of the hypothalamus−pituitary−adrenal (HPA) axis, coordinating the endocrine, behavioral, and…”
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Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs by Gilligan, Paul J, Cain, Gary A, Christos, Thomas E, Cook, Leonard, Drummond, Spencer, Johnson, Alexander L, Kergaye, Ahmed A, McElroy, John F, Rohrbach, Kenneth W

“…sigma receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel…”
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Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats by McElroy, J F, Wade, G N

“…This experiment examined both the short-term and the long-term effects of ovariectomy on brown adipose tissue growth and function in rats to determine if…”
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Piperidinyltetralin .sigma. Ligands by Gilligan, Paul J, Kergaye, Ahmed A, Lewis, Bryan M, McElroy, John F

“…Sigma receptor ligands have been proposed to be potential antipsychotic drugs based on their activity profile in animal behavioral models and their indirect…”
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Repetition, Contrariety, and Individualization in Edward II by McElroy, John F.

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Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test : Effects of Neurokinin-I Receptor Antagonists by WALLACE-BOONE, Tanya L, NEWTON, Amy E, WRIGHT, Robert N, LODGE, Nicholas J, MCELROY, John F

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Effects of CRF sub(1) receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests by Hogan, John B, Hodges, Donald B, Lelas, Snjezana, Gilligan, Paul J, McElroy, John F, Lindner, Mark D

“…Rationale: Benzodiazepines continue to be widely used for the treatment of anxiety, but it is well known that benzodiazepines have undesirable side effects,…”
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The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats by Lelas, Snjezana, Zeller, Kim L, Ward, Kathryn A, McElroy, John F

“…Compounds with a mechanism of action different from benzodiazepines may retain the anxiolytic effects of benzodiazepines with fewer side effects. CRF(1)…”
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The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats by McElroy, John F, Ward, Kathryn A, Zeller, Kim L, Jones, Keith W, Gilligan, Paul J, He, Liqi, Lelas, Snjezana

“…CRF(1) antagonists may be effective in the treatment of anxiety disorders while having fewer side effects compared with classical benzodiazepines. The effects…”
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Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1 H -pyrido[2,3- b ]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists by Dzierba, Carolyn D., Takvorian, Amy G., Rafalski, Maria, Kasireddy-Polam, Padmaja, Wong, Harvey, Molski, Thaddeus F., Zhang, Ge, Li, Yu-Wen, Lelas, Snjezana, Peng, Yong, McElroy, John F., Zaczek, Robert C., Taub, Rebecca A., Combs, Andrew P., Gilligan, Paul J., Trainor, George L.

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