Search Results - "McElroy, Andrew B."

Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold by Dumez, Estelle, Snaith, John S, Jackson, Richard F. W, McElroy, Andrew B, Overington, John, Wythes, Martin J, Withka, Jane M, McLellan, Thomas J

“…A generic macrocyclic peptide structure 2 was designed as a potential inhibitor of a range of proteinases, by using as a basis for the design the known…”
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Discovery of Potent & Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor for the Treatment of Thrombosis by Bunnage, Mark E, Blagg, Julian, Steele, John, Owen, Dafydd R, Allerton, Charlotte, McElroy, Andrew B, Miller, Duncan, Ringer, Tracy, Butcher, Ken, Beaumont, Kevin, Evans, Karen, Gray, Andrew J, Holland, Stephen J, Feeder, Neil, Moore, Robert S, Brown, David G

“…Thrombin-activatable fibrinolysis inhibitor (TAFI) has emerged as a key link between the coagulation and fibrinolysis cascades and represents a promising new…”
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Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor by McGeehan, Gerard M, Becherer, J. David, Bast, Robert C, Boyer, Cinda M, Champion, Brian, Connolly, Kevin M, Conway, James G, Furdon, Paul, Karp, Stephen, Kidao, Sudha, McElroy, Andrew B, Nichols, James, Pryzwansky, Katherine M, Schoenen, Frank, Sekut, Les, Truesdale, Anne, Verghese, Margrith, Warner, Janet, Ways, Judy P

“…Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages. TNF-alpha is synthesized…”
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Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor by Lovejoy, Brett, Cleasby, Anne, Hassell, Anne M., Longley, Kelly, Luthe, Michael A., Weigl, Debra, McGeehan, Gerard, McElroy, Andrew B., Drewry, David, Lambert, Millard H., Jordan, Steven R.

“…Collagenase is a zinc-dependent endoproteinase and is a member of the matrix metalloproteinase (MMP) family of enzymes. The MMPs participate in connective…”
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Conformationally constrained tachykinin analogs: potent and highly selective neurokinin NK-2 receptor agonists by Deal, Martyn J, Hagan, Russell M, Ireland, Simon J, Jordan, Christopher C, McElroy, Andrew B, Porter, Barry, Ross, Barry C, Stephens-Smith, Michaela, Ward, Peter

“…The design and synthesis of potent and selective neurokinin NK-2 receptor agonists 12 (GR64349) and 31 are described, together with structure-activity…”
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New .kappa.-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus by Scopes, David I. C, Hayes, Norman F, Bays, David E, Belton, David, Brain, John, Brown, Dearg S, Judd, Duncan B, McElroy, Andrew B, Meerholz, Clive A

“…The syntheses of some 1-[(3,4-dichlorophenyl)acetyl]-2- [(alkylamino)methyl]piperidines and their activities as kappa-opioid receptor agonists are described…”
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Design of Selective Thrombin Inhibitors Based on the (R)-Phe-Pro-Arg Sequence by Danilewicz, John C, Abel, Stuart M, Brown, Alan D, Fish, Paul V, Hawkeswood, Edward, Holland, Stephen J, James, Keith, McElroy, Andrew B, Overington, John, Powling, Michael J, Rance, David J

“…Potent and selective inhibitors of thrombin were sought based on the (R)-Phe-Pro-Arg sequence. The objective was to generate similar binding interactions to…”
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Matrix Metalloproteinase Inhibitors Containing a [(Carboxyalkyl)amino]zinc Ligand: Modification of the P1 and P2' Residues by Brown, Frank K, Brown, Peter J, Bickett, D. Mark, Chambers, C. Lynn, Davies, H. Geoff, Deaton, David N, Drewry, David, Foley, Michael, McElroy, Andrew B

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Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor by McElroy, Andrew B, Clegg, Stephen P, Deal, Martyn J, Ewan, George B, Hagan, Russell M, Ireland, Simon J, Jordan, Christopher C, Porter, Barry, Ross, Barry C

“…Incorporation of D-Pro9 into substance P related peptides is known to enhance neurokinin NK-2 receptor agonist potency and selectivity with respect to other…”
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New Spiropiperidines as Potent and Selective Non-Peptide Tachykinin NK2 Receptor Antagonists by Smith, Paul W, Cooper, Anthony W. J, Bell, Richard, Beresford, Isabel J. M, Gore, Paul M, McElroy, Andrew B, Pritchard, John M, Saez, Victoria, Taylor, Neil R

“…The synthesis of a series of 2-(5-fluoro-1H-indol-3-yl)ethyl spiropiperidines is described together with their tachykinin NK2 receptor affinities measured in a…”
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Matrix metalloproteinase inhibitors containing a [(carboxyalkyl)amino] zinc ligand: Modification of the P1 and P2' residues. [Erratum to document cited in CA120:238898] by Brown, Frank K, Brown, Peter J, Bickett, D. Mark, Chambers, C. Lynn, Davies, H. Geoff, Deaton, David N, Drewry, David, Foley, Michael, McElroy, Andrew B

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Synthesis, antinociceptive activity and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols by Judd, Duncan B, Brown, Dearg S, Lloyd, Jane E, McElroy, Andrew B, Scopes, David I. C, Birch, Phillip J, Hayes, Ann G, Sheehan, Michael J

“…A series of trans-3-(6- and 7-substituted-decahydro-4a-isoquinolinyl)phenols and trans-3-(octahydro-4a-isoquinolinyl)phenols have been synthesized as potential…”
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Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand : modification of the P1 and P2' residues by BROWN, F. K, BROWN, P. J, MCGEEHAN, G. M, MYERS, P. L, NORTON, D, SALOVICH, J. M, SCHOENEN, F. J, WARD, P, BICKETT, D. M, CHAMBERS, C. L, DAVIES, H. G, DEATON, D. N, DREWRY, D, FOLEY, M, MCELROY, A. B, GREGSON, M

“…Systematic modification of the presumed P1 side chain in a series of (carboxyalkyl)amino-based inhibitors of matrix metalloproteinases enabled identification…”
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Regulation of tumour necrosis factor- alpha processing by a metallproteinase inhibitor by McGeehan, Gerard M, Becherer, JDavid, Bast, Robert C, Boyer, Cinda M, Champion, Brian, Connolly, Kevin M, Conway, James G, Furdon, Paul, Karp, Stephen, Kidao, Sudha, McElroy, Andrew B, Nichols, James, Pryzwansky, Katherine M, Schoenen, Frank, Sekut, Les, Truesdale, Anne

“…Tumour necrosis factor- alpha (TNF- alpha ) is potent pro-inflammatory agent produced primarily by activated monocytes and macrophages. TNF- alpha is…”
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