Search Results - "McElhinny, Stephanie A. Nick"

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases by Nick McElhinny, Stephanie A, Watts, Brian E, Kumar, Dinesh, Watt, Danielle L, Lundström, Else-Britt, Burgers, Peter M.J, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A

“…Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their…”
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Genome instability due to ribonucleotide incorporation into DNA by Kunkel, Thomas A, McElhinny, Stephanie A Nick, Kumar, Dinesh, Clark, Alan B, Watt, Danielle L, Watts, Brian E, Lundström, Else-Britt, Johansson, Erik, Chabes, Andrei

“…Polymerase exclusion of ribonucleotides during DNA replication is imperfect. New data indicate that DNA polymerase ϵ incorporates into DNA ribonucleotides that…”
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Division of Labor at the Eukaryotic Replication Fork by Nick McElhinny, Stephanie A., Gordenin, Dmitry A., Stith, Carrie M., Burgers, Peter M.J., Kunkel, Thomas A.

“…DNA polymerase δ (Pol δ) and DNA polymerase ɛ (Pol ɛ) are both required for efficient replication of the nuclear genome, yet the division of labor between…”
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Mismatch repair balances leading and lagging strand DNA replication fidelity by Lujan, Scott A, Williams, Jessica S, Pursell, Zachary F, Abdulovic-Cui, Amy A, Clark, Alan B, Nick McElhinny, Stephanie A, Kunkel, Thomas A

“…The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase…”
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Differential correction of lagging-strand replication errors made by DNA polymerases α and δ by Nick McElhinny, Stephanie A, Kissling, Grace E, Kunkel, Thomas A

“…Mismatch repair (MMR) of replication errors requires DNA ends that can direct repair to the newly synthesized strand containing the error. For all but those…”
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Genome-wide model for the normal eukaryotic DNA replication fork by Larrea, Andres A., Lujan, Scott A., McElhinny, Stephanie A. Nick, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A., Kunkel, Thomas A.

“…To investigate DNA replication enzymology across the nuclear genome of budding yeast, deep sequencing was used to establish the pattern of uncorrected…”
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Evidence for Extrinsic Exonucleolytic Proofreading by McElhinny, Stephanie A. Nick, Pavlov, Youri I., Kunkel, Thomas A.

“…Exonucleolytic proofreading of DNA synthesis errors is one of the major determinants ofgenome stability. However, many DNA transactions that contribute to…”
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Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ε by WILLIAMS, Jessica S, CLAUSES, Anders R, NICK MCELHINNY, Stephanie A, WATTS, Brian E, JOHANSSON, Erik, KUNKEL, Thomas A

“…We have investigated the ability of the 3′ exonuclease activity of S. cerevisiae DNA polymerase ε (Pol ε) to proofread newly inserted ribonucleotides (rNMPs)…”
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Basic research opportunities focused on bio-based and bio-inspired materials and potential applications by Nick McElhinny, Stephanie A, Becker, Jennifer J

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A Gradient of Template Dependence Defines Distinct Biological Roles for Family X Polymerases in Nonhomologous End Joining by Nick McElhinny, Stephanie A., Havener, Jody M., Garcia-Diaz, Miguel, Juárez, Raquel, Bebenek, Katarzyna, Kee, Barbara L., Blanco, Luis, Kunkel, Thomas A., Ramsden, Dale A.

“…Three Pol X family members have been linked to nonhomologous end joining (NHEJ) in mammals. Template-independent TdT promotes diversity during NHEJ-dependent…”
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Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase by Nick McElhinny, Stephanie A., Ramsden, Dale A.

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fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins by Zhong, Xuejun, Garg, Parie, Stith, Carrie M, McElhinny, Stephanie A. Nick, Kissling, Grace E, Burgers, Peter M.J, Kunkel, Thomas A

“…DNA polymerase zeta (pol ζ) participates in several DNA transactions in eukaryotic cells that increase spontaneous and damage-induced mutagenesis. To better…”
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Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair by Mahajan, Kiran N., Nick McElhinny, Stephanie A., Mitchell, Beverly S., Ramsden, Dale A.

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Inefficient Proofreading and Biased Error Rates during Inaccurate DNA Synthesis by a Mutant Derivative of Saccharomyces cerevisiae DNA Polymerase δ by McElhinny, Stephanie A. Nick, Stith, Carrie M., Burgers, Peter M.J., Kunkel, Thomas A.

“…DNA polymerase δ (pol δ) is a high fidelity eukaryotic enzyme that participates in DNA repair and is essential for DNA replication. Toward the goal of…”
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specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis by Juárez, Raquel, Ruiz, José F, McElhinny, Stephanie A. Nick, Ramsden, Dale, Blanco, Luis

“…Human DNA polymerase mu (Polμ) is a family X member that has terminal transferase activity but, in spite of a non-orthodox selection of the template…”
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Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ by Williams, Jessica S., Clausen, Anders R., Nick McElhinny, Stephanie A., Watts, Brian E., Johansson, Erik, Kunkel, Thomas A.

“…► DNA polymerase epsilon proofreads ribonucleotides inserted into DNA. ► Ribonucleotide proofreading by Pol epsilon stabilizes the genome. ► Proofreading of…”
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Ribonucleotide incorporation by yeast DNA polymerase ζ by Makarova, Alena V., McElhinny, Stephanie A. Nick, Watts, Brian E., Kunkel, Thomas A., Burgers, Peter M.

“…•Ribonucleotides are frequently incorporated by DNA polymerases during replication.•DNA polymerase ζ carries out most DNA synthesis during damage-induced…”
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Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends by Nick McElhinny, Stephanie A., Snowden, Carey M., McCarville, Joseph, Ramsden, Dale A.

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Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta} by Nick McElhinny, Stephanie A, Kissling, Grace E, Kunkel, Thomas A

“…Mismatch repair (MMR) of replication errors requires DNA ends that can direct repair to the newly synthesized strand containing the error. For all but those…”
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Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair by Nick McElhinny, Stephanie A., Ramsden, Dale A.

“…The nonhomologous end‐joining pathway is a major means for repairing double‐strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the…”
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