Search Results - "McEachern, Michael J."

Break-induced replication and recombinational telomere elongation in yeast by McEachern, Michael J, Haber, James E

“…When a telomere becomes unprotected or if only one end of a chromosomal double-strand break succeeds in recombining with a template sequence, DNA can be…”
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A Genome-Wide Screen for Saccharomyces cerevisiae Deletion Mutants That Affect Telomere Length by Askree, Syed H., Yehuda, Tal, Smolikov, Sarit, Gurevich, Raya, Hawk, Joshua, Coker, Carrie, Krauskopf, Anat, Kupiec, Martin, McEachern, Michael J., Pardue, Mary-Lou

“…Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that play a central role in guarding the integrity of the genome by…”
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Maintenance of Very Long Telomeres by Recombination in the Kluyveromyces lactis stn1-M1 Mutant Involves Extreme Telomeric Turnover, Telomeric Circles, and Concerted Telomeric Amplification by Xu, Jianing, McEachern, Michael J.

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Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scrambling by Xu, Jianing, McEachern, Michael J

“…Considerable evidence now supports the idea that the moderate telomere lengthening produced by recombinational telomere elongation (RTE) in a Kluyveromyces…”
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Recombinational Telomere Elongation Promoted by DNA Circles by Natarajan, Shobhana, McEachern, Michael J.

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Telomere Loops and Homologous Recombination-Dependent Telomeric Circles in a Kluyveromyces lactis Telomere Mutant Strain by Cesare, Anthony J., Groff-Vindman, Cindy, Compton, Sarah A., McEachern, Michael J., Griffith, Jack D.

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Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity by Basenko, Evelina, Topcu, Zeki, McEachern, Michael J

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Recombination Can Cause Telomere Elongations as Well as Truncations Deep within Telomeres in Wild-Type Kluyveromyces lactis Cells by Bechard, Laura H, Jamieson, Nathan, McEachern, Michael J

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Evidence for an Additional Base-Pairing Element between the Telomeric Repeat and the Telomerase RNA Template in Kluyveromyces lactis and Other Yeasts by Wang, Zhi-Ru, Guo, Leilei, Chen, Lizhen, McEachern, Michael J.

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Functional Analysis of the Single Est1/Ebs1 Homologue in Kluyveromyces lactis Reveals Roles in both Telomere Maintenance and Rapamycin Resistance by Hsu, Min, Young Yu, Eun, Sprusansky, Ondrej, McEachern, Michael J, Lue, Neal F

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Mutant Telomeric Repeats in Yeast Can Disrupt the Negative Regulation of Recombination-Mediated Telomere Maintenance and Create an Alternative Lengthening of Telomeres-Like Phenotype by Bechard, Laura H., Butuner, Bilge D., Peterson, George J., McRae, Will, Topcu, Zeki, McEachern, Michael J.

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Telomerase core components protect Candida telomeres from aberrant overhang accumulation by Hsu, Min, McEachern, Michael J, Dandjinou, Alain T, Tzfati, Yehuda, Orr, Erica, Blackburn, Elizabeth H, Lue, Neal F

“…Telomerase is a cellular reverse transcriptase that extends one strand (the G-strand) of the telomere terminal repeats. Aside from this role in telomere length…”
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Recombination at Long Mutant Telomeres Produces Tiny Single- and Double-Stranded Telomeric Circles by Groff-Vindman, Cindy, Cesare, Anthony J., Natarajan, Shobhana, Griffith, Jack D., McEachern, Michael J.

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A Mutation in the STN1 Gene Triggers an Alternative Lengthening of Telomere-Like Runaway Recombinational Telomere Elongation and Rapid Deletion in Yeast by Iyer, Shilpa, Chadha, Ashley D., McEachern, Michael J.

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Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes by Mason, Jennifer M O, McEachern, Michael J

“…Subtelomeric regions have several unusual characteristics, including complex repetitive structures, increased rates of evolution, and enrichment for genes…”
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Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis by Topcu, Z, Nickles, K, Davis, C, McEachern, M.J

“…Eukaryotic cells, including some human cancers, that lack telomerase can sometimes maintain telomeres by using recombination. It was recently proposed that…”
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Chromosome ends as adaptive beginnings: the potential role of dysfunctional telomeres in subtelomeric evolvability by Mason, Jennifer M. O., McEachern, Michael J.

“…Telomeres serve as protective caps that help the cell differentiate between the naturally occurring ends of chromosomes and double-stranded breaks. When…”
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Factors Influencing the Recombinational Expansion and Spread of Telomeric Tandem Arrays in Kluyveromyces lactis by Natarajan, Shobhana, Groff-Vindman, Cindy, McEachern, Michael J

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Telomere Fusions Caused by Mutating the Terminal Region of Telomeric DNA by McEachern, Michael J., Iyer, Shilpa, Fulton, Tracy Boswell, Blackburn, Elizabeth H.

“…Mutations in the template region of a telomerase RNA gene can lead to the corresponding sequence alterations appearing in newly synthesized telomeric repeats…”
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Genetic Dissection of the Kluyveromyces lactis Telomere and Evidence for Telomere Capping Defects in TER1 Mutants with Long Telomeres by Underwood, Dana H, Carroll, Coleen, McEachern, Michael J

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