Search Results - "McDyer, Fionnuala"

Identification and Validation of an Anthracycline/ Cyclophosphamide-Based Chemotherapy Response Assay in Breast Cancer by MULLIGAN, Jude M, HILL, Laura A, QUINN, Jennifer E, LINDOR, Noralane M, MULLAN, Paul B, JAMES, Colin R, WALKER, Steven M, KERR, Peter, JAMES, Jacqueline, DAVISON, Timothy S, PROUTSKI, Vitali, SALTO-TELLEZ, Manuel, DEHARO, Steve, JOHNSTON, Patrick G, COUCH, Fergus J, HARKIN, D. Paul, KENNEDY, Richard D, IRWIN, Gareth, BOYLE, David, KEATING, Katherine E, RAJI, Olaide Y, MCDYER, Fionnuala A, O'BRIEN, Eamonn, BYLESJO, Max

“…There is no method routinely used to predict response to anthracycline and cyclophosphamide-based chemotherapy in the clinic; therefore patients often receive…”
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Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue by KENNEDY, Richard D, BYLESJO, Max, GOFFARD, Nicolas, HEY, Peter, MCDYER, Fionnuala, MULLIGAN, Karl, MUSSEN, Julie, O'BRIEN, Eamonn, OLIVER, Gavin, WALKER, Steven M, MULLIGAN, Jude M, WILSON, Claire, KERR, Peter, WINTER, Andreas, O'DONOGHUE, Diarmuid, MULCAHY, Hugh, O'SULLIVAN, Jacintha, SHEAHAN, Kieran, HYLAND, John, DHIR, Rajiv, BATHE, Oliver F, WINQVIST, Ola, MANNE, Upender, DAVISON, Timothy, SHANMUGAM, Chandrakumar, RAMASWAMY, Sridhar, LEON, Eduardo J, SMITH, William I, MCDERMOTT, Ultan, WILSON, Richard H, LONGLEY, Daniel, MARSHALL, John, CUMMINS, Robert, SARGENT, Daniel J, BLACK, Julie M, JOHNSTON, Patrick G, PAUL HARKIN, D, KAY, Elaine W, HOLT, Robert J, PROUTSKI, Vitali, AHDESMAKI, Miika, FARZTDINOV, Vadim

“…Current prognostic factors are poor at identifying patients at risk of disease recurrence after surgery for stage II colon cancer. Here we describe a DNA…”
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Distributional fold change test - a statistical approach for detecting differential expression in microarray experiments by Farztdinov, Vadim, McDyer, Fionnuala

“…Because of the large volume of data and the intrinsic variation of data intensity observed in microarray experiments, different statistical methods have been…”
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Importance of substantial weight loss for altering gene expression during cardiovascular lifestyle modification by Ellsworth, Darrell L., Mamula, Kimberly A., Blackburn, Heather L., McDyer, Fionnuala A., Jellema, Gera L., van Laar, Ryan, Costantino, Nicholas S., Engler, Renata J.M., Vernalis, Marina N.

“…Objective To examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Methods A prospective…”
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BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer by Gorski, Julia J, James, Colin R, Quinn, Jennifer E, Stewart, Gail E, Staunton, Kieran Crosbie, Buckley, Niamh E, McDyer, Fionnuala A, Kennedy, Richard D, Wilson, Richard H, Mullan, Paul B, Harkin, D. Paul

“…Expression profiling of BRCA1-deficient tumours has identified a pattern of gene expression similar to basal-like breast tumours. In this study, we examine…”
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Intensive cardiovascular risk reduction induces sustainable changes in expression of genes and pathways important to vascular function by Ellsworth, Darrell L, Croft, Jr, Daniel T, Weyandt, Jamie, Sturtz, Lori A, Blackburn, Heather L, Burke, Amy, Haberkorn, Mary Jane, McDyer, Fionnuala A, Jellema, Gera L, van Laar, Ryan, Mamula, Kimberly A, Chen, Yaqin, Vernalis, Marina N

“…Healthy lifestyle changes are thought to mediate cardiovascular disease risk through pathways affecting endothelial function and progression of…”
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Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours by Thomas, Laura E, Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M, Tee, Andrew R, McDyer, Fionnuala, Moore, Stephen, Cooper, David N, Upadhyaya, Meena

“…Neurofibromatosis type-1 (NF1) is a complex neurogenetic disorder characterised by the development of benign and malignant tumours of the peripheral nerve…”
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Abstract 4820: Identification of a metagene representing SRC activation which is predictive of response to Dasatinib by McCabe, Nuala, Wikstrom, Katarina, Delaney, Thomas, Walker, Steven M., Goffard, Nicolas, Deharo, Steve, Hill, Laura, McDyer, Fionnuala, Keating, Katherine, Harkin, Dennis P., Gourley, Charlie, Kennedy, Richard D.

“…Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancies in the Western World. The aim of this study was to identify…”
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Activation of and dependence on ataxia telangiectasia mutated kinase in PTEN-deficient tumor cells by McCabe, Nuala, Walker, Steven M., Goffard, Nicolas, Wikstrom, Katarina, Greenan, Caroline, McLean, Estelle, McDyer, Fionnuala A, Keating, Karen E, James, Iain, Harrison, Timothy, Mullan, Paul B, Harkin, D. Paul, Chen, Clark, Kennedy, Richard D.

“…Abstract only 10553 Background: Loss of PTEN function has been widely reported to cause up-regulation of the PI3K/AKT signalling pathway resulting in increased…”
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Identification and validation of an assay predictive of response and prognosis following anthracycline-based chemotherapy for early breast cancer by Mulligan, Jude M., Hill, Laura A., Deharo, Steve, Keating, Katherine E., Raji, Olaide, McDyer, Fionnuala A., James, Jacqueline, Irwin, Gareth, Boyle, David, Quinn, Jennifer E., Mullan, Paul B., James, Colin R., Salto-Tellez, Manuel, Davison, Timothy S., Johnston, Patrick, Couch, Fergus J., Harkin, D. Paul, Kennedy, Richard D.

“…Abstract only TPS11120 Background: Currently there is no biomarker to predict specific benefit from DNA-damaging anthracycline and cyclophosphamide-based…”
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Abstract 326: Investigation of molecular subtypes within FFPE breast cancer tumors using the Breast Cancer DSA by Deharo, Steve, Mulligan, Jude M., McDyer, Fionnuala A., Bylesjo, Max, Halfpenny, Iris, Delaney, Thomas, Quinn, Jennifer E., Couch, Fergus J., Proutski, Vitali, Harkin, Paul D., Kennedy, Richard D.

“…Microarray gene expression profiling has facilitated identification of molecular subtypes which can be associated with disease outcome and treatment response…”
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Abstract 1153: The development and utilization of a novel DNA microarray platform for biomarker and target identification in advanced prostate cancer by Walker, Steven M., McGoohan, Caroline, Mcdyer, Fionnuala, Oliver, Gavin R., McCabe, Nuala, Deharo, Steve, Johnston, Patrick G., Harkin, D Paul, Kennedy, Richard D.

“…Prostate cancer is the second leading cause of cancer-related deaths in men; specifically one in six men are diagnosed with prostate cancer in their lifetime…”
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