Search Results - "McDowell, I F"

contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment by Andrikoula, M, McDowell, I.F.W

“…LDL has been widely recognized as the major atherogenic lipoprotein and designated as the primary target for prevention of coronary heart disease (CHD);…”
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All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: A long-term prospective registry study by Neil, H.A.W, Cooper, J, Betteridge, D.J, Capps, N, McDowell, I.F.W, Durrington, P.N, Seed, M, Mann, J.I, Humphries, S.E

“…Abstract Objective To examine all-cause and cardiovascular mortality in patients with severe hypertriglyceridaemia. Methods 337 patients aged less than 80…”
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Coronary heart disease mortality in treated familial hypercholesterolaemia: Update of the UK Simon Broome FH register by Humphries, S.E., Cooper, J.A., Seed, M., Capps, N., Durrington, P.N., Jones, B., McDowell, I.F.W., Soran, H., Neil, H.A.W.

“…Patients with familial hypercholesterolaemia (FH) have an elevated risk of coronary heart disease (CHD). Here we compare changes in CHD mortality in patients…”
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High- but not low-dose folic acid improves endothelial function in coronary artery disease by Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F. W., Lewis, M. J., Lang, D.

“…Background  While folic acid (FA) reduces plasma homocysteine (Hcy), whether the simultaneous improvement in endothelial function is dependent on Hcy lowering…”
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Clinical experience of scoring criteria for Familial Hypercholesterolaemia (FH) genetic testing in Wales by Haralambos, K, Whatley, S.D, Edwards, R, Gingell, R, Townsend, D, Ashfield-Watt, P, Lansberg, P, Datta, D.B.N, McDowell, I.F.W

“…Abstract Background/Objective Familial Hypercholesterolaemia (FH) is caused by mutations in genes of the Low Density Lipoprotein (LDL) receptor pathway. A…”
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Oral folate enhances endothelial function in hyperhomocysteinaemic subjects by BELLAMY, M. F, MCDOWELL, I. F. W, RAMSEY, M. W, BROWNLEE, M, NEWCOMBE, R. G, LEWIS, M. I

“…Background Elevated plasma homocysteine (Hcy) is a risk factor for vascular disease. A postulated mechanism is vascular endothelial damage by homocysteine. Hcy…”
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Putative mechanisms for vascular damage by homocysteine by Bellamy, M. F., McDowell, I. F. W.

“…In homocystinuria homocysteine appears to be directly toxic to the vasculature, but in mild hyperhomocysteinaemia a cause and effect relationship remains…”
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A comparison of the effect of advice to eat either '5-a-day' fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine by ASHFIELD-WATT, P. A. L, WHITINGS, J. M, CLARK, Z. E, MOAT, S. J, NEWCOMBE, R. G, BURR, M. L, MCDOWELL, I. F. W

“…To assess and compare the effects of natural folate (100 micro g) with those of folic acid from fortified sources (100 micro g/day) on plasma folate and…”
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Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage by MOAT, S. J, HILL, M. H, MCDOWELL, I. F. W, PULLIN, C. H, ASHFIELD-WATT, P. A. L, CLARK, Z. E, WHITING, J. M, NEWCOMBE, R. G, LEWIS, M. J, POWERS, H. J

“…Various mechanisms have been proposed to explain the association between plasma total homocysteine (tHcy) and risk of cardiovascular disease, including…”
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Homocysteine and endothelial dysfunction: a link with cardiovascular disease by McDowell, I F, Lang, D

“…The nature of the link between homocysteine and cardiovascular disease has not yet been clearly established. Impaired endothelium-independent vasodilatation is…”
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Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria by Pullin, C. H., Bonham, J. R., McDowell, I. F. W., Lee, P. J., Powers, H. J., Wilson, J. F., Lewis, M. J., Moat, S. J.

“…Objectives: We sought to investigate the effects of short‐ and long‐term vitamin C therapy on endothelial dysfunction in patients with homocystinuria…”
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Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults by BELLAMY, M. F, MCDOWELL, I. F. W, RAMSEY, M. W, BROWNLEE, M, BONES, C, NEWCOMBE, R. G, LEWIS, M. J

“…Elevated plasma homocysteine is a risk factor for arteriosclerosis, but a cause-and-effect relationship remains to be fully established. Endothelial…”
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The effect of probucol and vitamin E treatment on the oxidation of low-density lipoprotein and forearm vascular responses in humans by McDowell, I F, Brennan, G M, McEneny, J, Young, I S, Nicholls, D P, McVeigh, G E, Bruce, I, Trimble, E R, Johnston, G D

“…This study investigates the hypothesis that lipid soluble antioxidants may increase the resistance of low-density lipoprotein (LDL) to oxidation and also…”
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Folic acid in endothelial function in familial hypercholesterolemia by Bellamy, M F, McDowell, I F, Lewis, M J

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Decreased circulating plasma lipids in patients with homocystinuria by Moat, S. J., Bonham, J. R., Allen, J. C., Powers, H. J., McDowell, I. F. W.

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Apolipoprotein E phenotype determined by agarose gel electrofocusing and immunoblotting by McDowell, I F, Wisdom, G B, Trimble, E R

“…Polymorphism at the apolipoprotein E (ApoE) locus is an important factor in the development of remnant (Type III) hyperlipidemia and also influences the…”
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Urinary catecholamines and metabolites in the immediate postoperative period following major surgery by Syed, Dr A A, Wheatley, H A, Badminton, M N, McDowell, I F W

“…Background: Induction of anaesthesia can precipitate catecholamine release from an undiscovered pheochromocytoma and induce a hypertensive crisis. However, it…”
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Simvastatin in severe hypercholesterolaemia: a placebo controlled trial by McDowell, IF, Smye, M., Trinick, T., Shortt, JA, Archibald, MP, Trimble, ER, Nicholls, DP

“…The effect of simvastatin in 27 patients with severe primary hypercholesterolaemia was assessed by a double‐blind placebo controlled parallel group trial…”
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Heterozygosity for the haemochromatosis mutation HFE C282Y is not a risk factor for angina by Feeney, G P, Ashfield-Watt, P A L, Burr, M L, Dunstan, F D J, McDowell, I F W, Worwood, M

“…Two large surveys suggested that possession of the HFE C282Y mutation may predispose to cardiovascular disorders, cardiovascular death in women, 5 and acute…”
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A rapid method for measurement of the susceptibility to oxidation of low-density lipoprotein by McDowell, I F, McEneny, J, Trimble, E R

“…Oxidation of low-density lipoprotein (LDL) may be important in the pathogenesis of atherosclerosis. We describe a method which measures the oxidation…”
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