Search Results - "McDougall, Robin"

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships by McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna

“…Functional human-on-a-chip systems hold great promise to enable quantitative translation to in vivo outcomes. Here, we explored this concept using a pumpless…”
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Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? by Verner, Marc-André, McDougall, Robin, Glynn, Anders, Andersen, Melvin E, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…A recent meta-analysis based on data from > 7,000 pregnancies reported an association between prenatal polychlorinated biphenyl (PCB)-153 exposure and reduced…”
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Using population physiologically based pharmacokinetic modeling to determine optimal sampling times and to interpret biological exposure markers: The example of occupational exposure to styrene by Verner, Marc-André, McDougall, Robin, Johanson, Gunnar

“…► We put forward a framework to optimize biomonitoring using population PBPK modeling. ► The optimal time to measure styrene in venous blood is at the end of…”
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Hydrology, Rheumatology, and Rehabilitation: The Campaigning of Fortescue Fox by Fox, Robin McDougall

“…Soon after qualification, Fortescue Fox (1858-1940) began practice in a Scottish spa where he acquired a lifelong interest in chronic disorders, especially…”
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Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) by Verner, Marc-André, Loccisano, Anne E, Morken, Nils-Halvdan, Yoon, Miyoung, Wu, Huali, McDougall, Robin, Maisonet, Mildred, Marcus, Michele, Kishi, Reiko, Miyashita, Chihiro, Chen, Mei-Huei, Hsieh, Wu-Shiun, Andersen, Melvin E, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birth weight in epidemiologic studies. This association could be…”
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Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib by Rosen, Ezra, Yap, Timothy A, Lee, Elizabeth K, Højgaard, Martin, Mettu, Niharika B, Lheureux, Stephanie, Carneiro, Benedito A, Plummer, Ruth, Fretland, Adrian J, Ulanet, Danielle, Xu, Yi, McDougall, Robin, Koehler, Maria, Fontana, Elisa

“…Camonsertib is a highly selective and potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Dose-dependent anemia is a class-related…”
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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human by McDougall, Robin, Ramsden, Diane, Agarwal, Sagar, Agarwal, Saket, Aluri, Krishna, Arciprete, Michael, Brown, Christopher, Castellanos-Rizaldos, Elena, Charisse, Klaus, Chong, Saeho, Cichocki, Joseph, Fitzgerald, Kevin, Goel, Varun, Gu, Yongli, Guenther, Dale, Habtemariam, Bahru, Jadhav, Vasant, Janas, Maja, Jayaraman, Muthusamy, Kurz, Jeffrey, Li, Jing, Liu, Ju, Liu, Xiumin, Liou, Steven, Maclauchlin, Chris, Maier, Martin, Manoharan, Muthiah, Nair, Jayaprakash K, Robbie, Gabriel, Schmidt, Karyn, Smith, Peter, Theile, Christopher, Vaishnaw, Akshay, Waldron, Scott, Xu, Yuanxin, Zhang, Xuemei, Zlatev, Ivan, Wu, Jing-Tao

“…Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or antisense oligonucleotides, to -acetylgalactosamine (GalNAc) ligands…”
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Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey by Petersson, Carl, Zhou, Xin, Berghausen, Joerg, Cebrian, David, Davies, Michael, DeMent, Kevin, Eddershaw, Peter, Riedmaier, Arian Emami, Leblanc, Alix F., Manveski, Nenad, Marathe, Punit, Mavroudis, Panteleimon D., McDougall, Robin, Parrott, Neil, Reichel, Andreas, Rotter, Charles, Tess, David, Volak, Laurie P., Xiao, Guangqing, Yang, Zheng, Baker, James

“…Accurate prediction of human clearance (CL) and volume of distribution at steady state (V d,ss ) for small molecule drug candidates is an essential component…”
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Reconstructing exposures from biomarkers using exposure-pharmacokinetic modeling – A case study with carbaryl by Brown, Kathleen, Phillips, Martin, Grulke, Christopher, Yoon, Miyoung, Young, Bruce, McDougall, Robin, Leonard, Jeremy, Lu, Jingtao, Lefew, William, Tan, Yu-Mei

“…Sources of uncertainty involved in exposure reconstruction for short half-life chemicals were characterized using computational models that link external…”
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Associations of perfluoroalkyl substances by Verner, Marc-Andre, Loccisano, Anne E, Morken, Nils-Halvdan, Yoon, Miyoung, Wu, Huali, McDougall, Robin, Maisonet, Mildred, Marcus, Michele, Kishi, Reiko, Miyashita, Chihiro, Chen, Mei-Huei, Hsieh, Wu-Shiun, Andersen, Melvin E, Hi, Harvey J. Clewell, Longnecker, Matthew P

“…Environ Health Perspect 123:1317-1324; http://dx.doi.org/10.1289/ehp.1408837…”
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Lifetime PCB 153 bioaccumulation and pharmacokinetics in pilot whales: Bayesian population PBPK modeling and Markov chain Monte Carlo simulations by Weijs, Liesbeth, Roach, Anthony C., Yang, Raymond S.H., McDougall, Robin, Lyons, Michael, Housand, Conrad, Tibax, Detlef, Manning, Therese, Chapman, John, Edge, Katelyn, Covaci, Adrian, Blust, Ronny

“…•PBPK models for wild animals should address model uncertainty and variability.•Bayesian approach and MCMC simulations for reliable parameter…”
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A Case Study Addressing the Reliability of Polychlorinated Biphenyl Levels Measured at the Time of Breast Cancer Diagnosis in Representing Early-Life Exposure by VERNER, Marc-André, BACHELET, Delphine, MCDOUGALL, Robin, CHARBONNEAU, Michel, GUENEL, Pascal, HADDAD, Sami

“…To date, breast cancer epidemiologic studies have relied on blood or tissue specimens sampled at the time of diagnosis or a few years prior to assess lifetime…”
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What Do Late-life Polychlorinated Biphenyls (PCB) Levels Tell us on Lifetime Internal Exposure? An Evaluation of Exposure Misclassification in Retrospective Breast Cancer Epidemiologic Studies by Verner, Marc-André, Bachelet, Delphine, McDougall, Robin, Charbonneau, Michel, Guénel, Pascal, Haddad, Sami

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Internal Doses of PCB153 Estimated for Different Exposure Windows During Womenʼs Lifetime are Inversely Associated With the Incidence of Breast Cancer by Bachelet, Delphine, Verner, Marc-André, Charlier, Corinne, Arveux, Patrick, Kerbrat, Pierre, McDougall, Robin, Charbonneau, Michel, Haddad, Sami, Guénel, Pascal

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Optimization-based mechanism synthesis using multi-objective parallel asynchronous particle swarm optimization by McDougall, Robin

“…A distributed variant of multi-objective particle swarm optimization (MOPSO) called multi-objective parallel asynchronous particle swarm optimization (MOPAPSO)…”
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Optimization-based mechanism synthesis using multi-objective parallel asynchronous particle swarm optimization by McDougall, Robin

“…A distributed variant of multi-objective particle swarm optimization (MOPSO) called multi-objective parallel asynchronous particle swarm optimization (MOPAPSO)…”
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