Search Results - "McDonough, Sean M."

Bortezomib-Based Graft-Versus-Host Disease Prophylaxis in HLA-Mismatched Unrelated Donor Transplantation by KORETH, John, STEVENSON, Kristen E, SOIFFER, Robert J, RITZ, Jerome, ALYEA III, Edwin P, KIM, Haesook T, MCDONOUGH, Sean M, BINDRA, Bhavjot, ARMAND, Philippe, HO, Vincent T, CUTLER, Corey, BLAZAR, Bruce R, ANTIN, Joseph H

“…HLA-mismatched unrelated donor (MMUD) hematopoietic stem-cell transplantation (HSCT) is associated with increased graft-versus-host disease (GVHD) and impaired…”
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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 by Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina G, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Stone, Richard, Galinsky, Ilene, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens U, McDonough, Sean M, Wiesmann, Marion, Griffin, James D

“…The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2…”
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PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity by Peña-Cruz, Victor, McDonough, Sean M., Diaz-Griffero, Felipe, Crum, Christopher P., Carrasco, Ruben D., Freeman, Gordon J.

“…Langerhans cells (LCs) are known as “sentinels” of the immune system that function as professional antigen-presenting cells (APCs) after migration to draining…”
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Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease by Koreth, John, Matsuoka, Ken-ichi, Kim, Haesook T, McDonough, Sean M, Bindra, Bhavjot, Alyea, Edwin P, Armand, Philippe, Cutler, Corey, Ho, Vincent T, Treister, Nathaniel S, Bienfang, Don C, Prasad, Sashank, Tzachanis, Dmitrios, Joyce, Robin M, Avigan, David E, Antin, Joseph H, Ritz, Jerome, Soiffer, Robert J

“…A low daily dose of subcutaneous interleukin-2 increases the number and function of regulatory T cells and results in substantial improvement in about half of…”
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Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells by Burkhardt, Ute E, Hainz, Ursula, Stevenson, Kristen, Goldstein, Natalie R, Pasek, Mildred, Naito, Masayasu, Wu, Di, Ho, Vincent T, Alonso, Anselmo, Hammond, Naa Norkor, Wong, Jessica, Sievers, Quinlan L, Brusic, Ana, McDonough, Sean M, Zeng, Wanyong, Perrin, Ann, Brown, Jennifer R, Canning, Christine M, Koreth, John, Cutler, Corey, Armand, Philippe, Neuberg, Donna, Lee, Jeng-Shin, Antin, Joseph H, Mulligan, Richard C, Sasada, Tetsuro, Ritz, Jerome, Soiffer, Robert J, Dranoff, Glenn, Alyea, Edwin P, Wu, Catherine J

“…Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell…”
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Post-Transplantation B Cell Activating Factor and B Cell Recovery before Onset of Chronic Graft-versus-Host Disease by Jacobson, Caron A, Sun, Lixian, Kim, Haesook T, McDonough, Sean M, Reynolds, Carol G, Schowalter, Michael, Koreth, John, Cutler, Corey S, Ho, Vincent T, Alyea, Edwin P, Armand, Philippe, Blazar, Bruce R, Soiffer, Robert J, Antin, Joseph H, Ritz, Jerome, Sarantopoulos, Stefanie

“…Abstract Excessive levels of B cell activating factor (BAFF) are found in patients with active chronic graft-versus-host disease (cGVHD). In mice, BAFF has…”
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Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation by Jacobson, Caron A, Turki, Amin T, McDonough, Sean M, Stevenson, Kristen E, Kim, Haesook T, Kao, Grace, Herrera, Maria I, Reynolds, Carol G, Alyea, Edwin P, Ho, Vincent T, Koreth, John, Armand, Philippe, Chen, Yi-Bin, Ballen, Karen, Soiffer, Robert J, Antin, Joseph H, Cutler, Corey S, Ritz, Jerome

“…Double umbilical cord blood (DUCB) transplantation is an accepted transplantation strategy for patients without suitable human leukocyte antigen (HLA) matched…”
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Small Change: Saul to Paul, Again by McDonough, Sean M.

“…Such a name might seem ill-fitting, given Paul's activities on behalf of David's descendant.2 (One might feel that the name change would have been more…”
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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant by Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Current regimens for patient preparation, or conditioning, prior to bone marrow transplantation (BMT) limit the use of this curative procedure due to…”
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Competent to Judge: The Old Testament Connection Between 1 Corinthians 5 and 6 by McDonough, Sean M.

“…In 1 Cor. 5:13, Paul quotes from Deut. 17:7. What has not received attention is the significance of the original context of that verse. In Deut. 17:8, the…”
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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) by Lanieri, Leanne, Lamothe, Tahirih L, Miske, Oliver, McDonough, Sean M, Sarma, Ganapathy N, Bhattarai, Prashant, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Palchaudhuri, Rahul, Knihtila, Ryan, Pearse, Bradley R, Proctor, Jennifer L, Boitano, Anthony E, Cooke, Michael P, Davis, John C.

“…Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative…”
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Markers of Angiogenesis and Neovascularization Correlate with Functional Recovery of Thymic Epithelial Cells and T Cell Immune Reconstitution After Cord Blood Transplantation in Adults by Politikos, Ioannis, Kim, Haesook, Brown, Julia, McDonough, Sean M, Li, Lequn, Cutler, Corey, Soiffer, Robert J, Antin, Joseph H, Ballen, Karen, Ritz, Jerome, Boussiotis, Vassiliki A

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Ex Vivo Treatment of Umbilical Cord Blood with Prostaglandin E2 Alters the Molecular and Functional Properties of T Cells Via Modulating Wnt/β-Catenin Signaling by Li, Lequn, Nellore, Anoma, McDonough, Sean M, Politikos, Ioannis, Kim, Haesook, Nikiforow, Sarah, Soiffer, Robert J, Antin, Joseph H, Ballen, Karen, Cutler, Corey, Ritz, Jerome, Boussiotis, Vassiliki A

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Regulation of Apoptotic Pathways in Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) by Murase, Kazuyuki, Kawano, Yutaka, Ryan, Jeremy, Matsuoka, Ken-ichi, Bascug, Gregory, McDonough, Sean M, Smith, Robert, Lazo-Kallanian, Suzan, Daley, John, Koreth, John, Soiffer, Robert J, Letai, Anthony, Ritz, Jerome

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Recipient T-Cell Repertoire Diversity after Double Umbilical Cord Transplantation Correlates with Non-Relapse Mortality and Survival by Nikiforow, Sarah, MD PhD, Kim, Haesook T., PhD, McDonough, Sean M., MS, Emerson, Ryan, PhD, Hamm, David, MSc, Ballen, Karen K., MD, Boussiotis, Vassiliki A., MD, PhD, Soiffer, Robert J., MD, Antin, Joseph H., MD, Ritz, Jerome, MD, Cutler, Corey S., MD

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Maintenance of Naïve T Cells and a Diverse TCR Repertoire Are Critical for Reconstitution of EBV-Specific Immunity after Double Cord Blood Transplantation by Politikos, Ioannis, MD, Kim, Haesook T., PhD, Nikiforow, Sarah, MD PhD, Nellore, Anoma, MD, Li, Lequn, MD, PhD, McDonough, Sean M., MS, Soiffer, Robert J., MD, Antin, Joseph H., MD, Ballen, Karen K., MD, Cutler, Corey S., MD, Ritz, Jerome, MD, Boussiotis, Vassiliki A., MD, PhD

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CD25+ Regulatory T CELL-Depleted Donor Lymphocyte Infusion for Relapse After Allogeneic Transplantation – A PHASE 1 Study by Nikiforow, Sarah, Kim, Haesook, Kao, Grace, Sainvil, Marie-Michele, McDonough, Sean M, Armand, Philippe, Ho, Vincent T, Alyea, Edwin P, Cutler, Corey, Ritz, Jerome, Antin, Joseph H, Soiffer, Robert J, Koreth, John

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Evolution of T Cell Repertoire Diversity After Reduced-Intensity Conditioning and Double Umbilical Cord Blood Transplantation with or without Exposure to FT1050 (16,16-dimethyl Prostaglandin E2) by Nikiforow, Sarah, McDonough, Sean M, Emerson, Ryan O, Hamm, David, Kim, Haesook, Ballen, Karen, Boussiotis, Vassiliki A, Soiffer, Robert J, Antin, Joseph H, Ritz, Jerome, Cutler, Corey

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates by Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood…”
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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT by Hartigan, Adam J., Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Adams, Hillary L., McShea, Molly A., Hoban, Megan D., Panwar, Rajiv, Hyzy, Sharon L., Goncalves, Kevin A., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P.

“…For patients undergoing hematopoietic stem cell transplantation (HSCT), conditioning remains a primary source of transplant related morbidity and mortality and…”
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