Search Results - "McDonough, Alicia"

Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure by McDonough, Alicia A

“…One-hundred years ago, Starling articulated the interdependence of renal control of circulating blood volume and effective cardiac performance. During the past…”
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Our Editorial Fellowship Program: Building Synergism by Gyarmati, Georgina, McDonough, Alicia A

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Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis by Hu, Rui, McDonough, Alicia A, Layton, Anita T

“…The goal of the present study was to investigate the functional implications of sexual dimorphism in the pattern of transporters along the rodent nephron as…”
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Potassium homeostasis: sensors, mediators, and targets by McDonough, Alicia A., Fenton, Robert A.

“…Transmembrane potassium (K) gradients are key determinants of membrane potential that can modulate action potentials, control muscle contractility, and…”
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Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits by McDonough, Alicia A, Youn, Jang H

“…Potassium homeostasis has a very high priority because of its importance for membrane potential. Although extracellular K is only 2% of total body K , our…”
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Sex differences in renal electrolyte transport by McDonough, Alicia A., Layton, Anita T.

“…Women experience unique life events, for example, pregnancy and lactation, that challenge renal regulation of electrolyte homeostasis. Recent analyses of…”
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Impact of angiotensin II-mediated stimulation of sodium transporters in the nephron assessed by computational modeling by Edwards, Aurélie, McDonough, Alicia A

“…Angiotensin II (ANG II) raises blood pressure partly by stimulating tubular Na reabsorption. The effects of ANG II on tubular Na transporters (i.e., channels,…”
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Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron by Zhang, Jiandong, Rudemiller, Nathan P., Patel, Mehul B., Karlovich, Norah S., Wu, Min, McDonough, Alicia A., Griffiths, Robert, Sparks, Matthew A., Jeffs, Alexander D., Crowley, Steven D.

“…Hypertension is among the most prevalent and catastrophic chronic diseases worldwide. While the efficacy of renin angiotensin system (RAS) blockade in lowering…”
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Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis by Veiras, Luciana C, Girardi, Adriana C C, Curry, Joshua, Pei, Lei, Ralph, Donna L, Tran, An, Castelo-Branco, Regiane C, Pastor-Soler, Nuria, Arranz, Cristina T, Yu, Alan S L, McDonough, Alicia A

“…Compared with males, females have lower BP before age 60, blunted hypertensive response to angiotensin II, and a leftward shift in pressure natriuresis. This…”
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Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced Hypertension by Norlander, Allison E, Saleh, Mohamed A, Kamat, Nikhil V, Ko, Benjamin, Gnecco, Juan, Zhu, Linjue, Dale, Bethany L, Iwakura, Yoichiro, Hoover, Robert S, McDonough, Alicia A, Madhur, Meena S

“…Angiotensin II–induced hypertension is associated with an increase in T-cell production of interleukin-17A (IL-17A). Recently, we reported that IL-17A mice…”
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The Highs and Lows of Potassium Intake in CKD-Does One Size Fit All? by Terker, Andrew S, Saritas, Turgay, McDonough, Alicia A

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The Highs and Lows of Potassium Intake in CKD—Does One Size Fit All? by Terker, Andrew S., Saritas, Turgay, McDonough, Alicia A.

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Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na + and K by Edwards, Aurélie, Ralph, Donna L, Mercado, Adriana, McDonough, Alicia A

“…Chronic infusion of subpressor level of angiotensin II (ANG II) increases the abundance of Na transporters along the distal nephron, balanced by suppression of…”
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Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis by Rengarajan, Srinivas, Lee, Donna H, Oh, Young Taek, Delpire, Eric, Youn, Jang H, McDonough, Alicia A

“…Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated with reduced phosphorylation (p) of the distal tubule Na(+)-Cl(-)…”
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Considerations when quantitating protein abundance by immunoblot by McDonough, Alicia A, Veiras, Luciana C, Minas, Jacqueline N, Ralph, Donna Lee

“…The development of the immunoblot to detect and characterize a protein with an antisera, even in a crude mixture, was a breakthrough with wide-ranging and…”
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Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles by Torres-Pinzon, Diana L, Ralph, Donna L, Veiras, Luciana C, McDonough, Alicia A

“…Kidneys continuously filter an enormous amount of sodium and adapt kidney Na reabsorption to match Na intake to maintain circulatory volume and electrolyte…”
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Sex differences in renal transporters: assessment and functional consequences by McDonough, Alicia A., Harris, Autumn N., Xiong, Lingyun (Ivy), Layton, Anita T.

“…Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The epithelial transport processes along the renal tubule that match output to…”
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Estimating in vivo potassium distribution and fluxes with stable potassium isotopes by Youn, Jang H, Oh, Young Taek, Gili, Stefania, McDonough, Alicia A, Higgins, John

“…Extracellular potassium (K ) homeostasis is achieved by a concerted effort of multiple organs and tissues. A limitation in studies of K homeostasis is…”
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Stable potassium isotopes ( 41 K/ 39 K) track transcellular and paracellular potassium transport in biological systems by Higgins, John A, Ramos, Danielle Santiago, Gili, Stefania, Spetea, Cornelia, Kanoski, Scott, Ha, Darren, McDonough, Alicia A, Youn, Jang H

“…As the most abundant cation in archaeal, bacterial, and eukaryotic cells, potassium (K ) is an essential element for life. While much is known about the…”
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Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice by Kamat, Nikhil V, Thabet, Salim R, Xiao, Liang, Saleh, Mohamed A, Kirabo, Annet, Madhur, Meena S, Delpire, Eric, Harrison, David G, McDonough, Alicia A

“…Ample genetic and physiological evidence establishes that renal salt handling is a critical regulator of blood pressure. Studies also establish a role for the…”
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