Search Results - "McDonnell, R. P."

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations by Zou, Helen Y., Li, Qiuhua, Engstrom, Lars D., West, Melissa, Appleman, Vicky, Wong, Katy A., McTigue, Michele, Deng, Ya-Li, Liu, Wei, Brooun, Alexei, Timofeevski, Sergei, McDonnell, Scott R. P., Jiang, Ping, Falk, Matthew D., Lappin, Patrick B., Affolter, Timothy, Nichols, Tim, Hu, Wenyue, Lam, Justine, Johnson, Ted W., Smeal, Tod, Charest, Al, Fantin, Valeria R.

“…Significance Overcoming resistance to targeted kinase inhibitors is a major clinical challenge in oncology. Development of crizotinib resistance through the…”
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Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma by McDonnell, Scott R.P., Hwang, Steven R., Rolland, Delphine, Murga-Zamalloa, Carlos, Basrur, Venkatesha, Conlon, Kevin P., Fermin, Damian, Wolfe, Thomas, Raskind, Alexander, Ruan, Chunhai, Jiang, Jian-Kang, Thomas, Craig J., Hogaboam, Cory M., Burant, Charles F., Elenitoba-Johnson, Kojo S.J., Lim, Megan S.

“…The mechanisms underlying the pathogenesis of the constitutively active tyrosine kinase nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressing…”
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Mezagitamab in systemic lupus erythematosus: clinical and mechanistic findings of CD38 inhibition in an autoimmune disease by McDonnell, Scott R P, Nguyen, Van Anh, Walton, Noah M, Merkwirth, Carsten, Hong, Feng, Berg, Deborah, Muensterman, Elena Tomaselli, Furie, Richard A

“…ObjectiveTo evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic…”
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Effect of divergence in phenotypic residual feed intake on methane emissions, ruminal fermentation, and apparent whole-tract digestibility of beef heifers across three contrasting diets by McDonnell, R P, Hart, K J, Boland, T M, Kelly, A K, McGee, M, Kenny, D A

“…This study aimed to examine the effect of divergent phenotypic ranking for residual feed intake (RFI) on ruminal CH emissions, diet digestibility, and indices…”
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NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma by Murga-Zamalloa, C A, Mendoza-Reinoso, V, Sahasrabuddhe, A A, Rolland, D, Hwang, S R, McDonnell, S R P, Sciallis, A P, Wilcox, R A, Bashur, V, Elenitoba-Johnson, K, Lim, M S

“…Mechanisms by which NPM-ALK signaling regulates cell migration, invasion and contributes to the oncogenesis of anaplastic large cell lymphoma (ALCL) are not…”
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NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis by McDonnell, S R P, Hwang, S R, Basrur, V, Conlon, K P, Fermin, D, Wey, E, Murga-Zamalloa, C, Zeng, Z, Zu, Y, Elenitoba-Johnson, K S J, Lim, M S

“…Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. In 70–80% of cases, the chromosomal aberration t…”
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Determining the critical plant test potassium concentration for annual and Italian ryegrass on dairy pastures in south‐western Australia by McDonnell, R. P., Staines, M. vH, Bolland, M. D. A.

“…Potassium fertilization in intensive grassland systems is particularly important on sandy soils with limited K storage capacity. A 3‐year plot experiment was…”
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Effect of divergence in phenotypic residual feed intake on methane emissions, ruminal fermentation, and apparent whole-tract digestibility of beef heifers across three contrasting diets1 by McDonnell, R. P., Hart, K. J., Boland, T. M., Kelly, A. K., McGee, M., Kenny, D. A.

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Performance of five pasture-based dairy systems with increasing levels of nitrogen fertiliser and associated stocking rates by Staines, M. V. H., Morris, R. J., Bolland, M. D. A., McDonnell, R. P.

“…A farm systems experiment comparing five pasture-based dairy systems was conducted in south-western Australia over 4 years on an annual ryegrass:subterranean…”
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Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance by Green, Jennifer L., Osterhout, Robin E., Klova, Amy L., Merkwirth, Carsten, McDonnell, Scott R.P., Zavareh, Reza Beheshti, Fuchs, Bryan C., Kamal, Adeela, Jakobsen, Jørn S.

“…Although anti-tumor activities of type I interferons (IFNs) have been recognized for decades, the molecular mechanisms contributing to clinical response remain…”
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Effect of divergence in phenotypic residual feed intake on methane emissions, ruminal fermentation, and apparent whole-tract digestibility of beef heifers across three contrasting diets 1 by McDonnell, R P, Hart, K J, Boland, T M, Kelly, A K, McGee, M, Kenny, D A

“…This study aimed to examine the effect of divergent phenotypic ranking for residual feed intake (RFI) on ruminal CH4 emissions, diet digestibility, and indices…”
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Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma by Hwang, Steven R, Murga-Zamalloa, Carlos, Brown, Noah, Basappa, Johnvesly, McDonnell, Scott RP, Mendoza-Reinoso, Veronica, Basrur, Venkatesha, Wilcox, Ryan, Elenitoba-Johnson, Kojo, Lim, Megan S

“…PKM2 (pyruvate kinase M2), a critical regulator of glycolysis, is phosphorylated by numerous growth factor receptors and oncogenic tyrosine kinases including…”
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NPM-ALK signals through glycogen synthase kinase 3[beta] to promote oncogenesis by Mcdonnell, S R P, Hwang, S R, Basrur, V, Conlon, K P, Fermin, D, Wey, E, Murga-zamalloa, C, Zeng, Z, Zu, Y, Elenitoba-johnson, K S J, Lim, M S

“…Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. In 70-80% of cases, the chromosomal aberration…”
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PTBP1 Interacts with PKM2 in an NPM-ALK-Dependent Manner and Contributes to the Pathogenesis of Anaplastic Large Cell Lymphoma (ALCL) by Basappa, Johnvesly, Hwang, Steven R, McDonnell, Scott RP, Basrur, Venkatesh, Murga-Zamalloa, Carlos, Elenitoba-Johnson, Kojo S.J., Lim, Megan S

“…Introduction: Pyruvate kinase (PKM2) is a glycolytic enzyme that plays an important role in cancer metabolism. Our previous work demonstrated that NPM-ALK…”
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Phase 1b study of the anti-CD38 antibody mezagitamab in patients with relapsed/refractory multiple myeloma by Krishnan, Amrita Y., Patel, Krina K., Mohan, Meera, Jagannath, Sundar, Niesvizky, Ruben, Silbermann, Rebecca W., Yu, Ziji, Long, Tao, McDonnell, Scott R. P., Berg, Deborah, Stockerl-Goldstein, Keith E.

“…•In a phase 1b study of relapsed/refractory myeloma, the anti-CD38 antibody mezagitamab was well tolerated and showed preliminary activity.•At the recommended…”
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Identification of PKM2 Interacting Proteins by Tandem Mass Spectrometry by Hwang, Steven Ray, McDonnell, Scott RP, Basrur, Venkatesh, Conlon, Kevin P, Fermin, Damian, Murga‐Zamalloa, Carlos, Elenitoba‐Johnson, Kojo SJ, Lim, Megan S

“…Abstract only Pyruvate Kinase M2 (PKM2) plays a key role in aerobic glycolysis and the metabolic phenotype that is critical for cancer cell growth and…”
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Wiskott-Aldrich Protein Is Phosphorylated by NPM-ALK and Regulates the Proliferation and Invasion of Anaplastic Large Cell Lymphoma by Murga-Zamalloa, Carlos, Hwang, Steven R, Sahasrabuddhe, Anagh A, McDonnell, Scott RP, Basrur, Venkatesha, Nikolovska-Coleska, Zaneta, Elenitoba-Johnson, Kojo S.J., Lim, Megan S.

“…Abstract 1535 Anaplastic large cell lymphoma (ALCL) is a subtype of mature T cell lymphoma. The NPM-ALK fusion protein is expressed in 80% of pediatric ALCL…”
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Phosphorylation of PKM2 by NPM-ALK Regulates a Metabolic Shift and Increased Oncogenic Potential by McDonnell, Scott RP, Hwang, Steven R, Basrur, Venkatesha, Conlon, Kevin, Fermin, Damian, Murga-Zamalloa, Carlos, Rolland, Delphine C.M., Thomas, Craig J., Elenitoba-Johnson, Kojo SJ, Lim, Megan S.

“…Abstract 896 Anaplastic Large Cell Lymphoma (ALCL) is a common form of pediatric non-Hodgkin lymphoma that is often characterized by the chromosomal…”
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NPM-ALK Regulated GSK3β Phosphorylation Results in Mcl-1 and CDC25A Accumulation and Enhanced Oncogenic Potential by McDonnell, Scott RP, Hwang, Steven R, Basrur, Venkatesha, Conlon, Kevin P, Fermin, Damian, Wey, Elizabeth, Murga-Zamalloa, Carlos, Zeng, Zihua, Zu, Youli, Elenitoba-Johnson, Kojo SJ, Lim, Megan S

“…Abstract 586 Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. ALCLs are frequently characterized by…”
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Enterfernung und Wiedergewinnung von Phenolen aus Industrieabwässern mit polymeren Amberlit XAD-Adsorbentien by Crook, E. H., McDonnell, R. P., McNulty, J. T.

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