Search Results - "McDonnell, Donald"

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer by Liu, Wen, Chakraborty, Binita, Safi, Rachid, Kazmin, Dmitri, Chang, Ching-yi, McDonnell, Donald P.

“…Hypercholesterolemia and dyslipidemia are associated with an increased risk for many cancer types and with poor outcomes in patients with established disease…”
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Estrogen Receptor Signaling in the Immune System by Chakraborty, Binita, Byemerwa, Jovita, Krebs, Taylor, Lim, Felicia, Chang, Ching-Yi, McDonnell, Donald P

“…The immune system functions in a sexually dimorphic manner, with females exhibiting more robust immune responses than males. However, how female sex hormones…”
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Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer by McDonnell, Donald P, Wardell, Suzanne E, Norris, John D

“…Drugs that inhibit estrogen receptor alpha (ERα) or that block the production of estrogens remain frontline interventions in the treatment and management of…”
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Eosinophilia in cancer and its regulation by sex hormones by Artham, Sandeep, Chang, Ching-Yi, McDonnell, Donald P.

“…Gender differences in the functionality of the immune system have been attributed, in part, to direct and indirect effects of sex steroids, especially…”
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Cholesterol and breast cancer pathophysiology by Nelson, Erik R, Chang, Ching-yi, McDonnell, Donald P

“…Highlights • Elevated cholesterol is associated with breast cancer risk. • Cholesterol promotes breast tumor growth and metastasis in murine models. • A…”
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27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology by Nelson, Erik R., Wardell, Suzanne E., Jasper, Jeff S., Park, Sunghee, Suchindran, Sunil, Howe, Matthew K., Carver, Nicole J., Pillai, Ruchita V., Sullivan, Patrick M., Sondhi, Varun, Umetani, Michihisa, Geradts, Joseph, McDonnell, Donald P.

“…Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine…”
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PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo by Sha, Yonggang, Wu, Jian, Paul, Barry, Zhao, Yue, Mathews, Parker, Li, Zhiguo, Norris, John, Wang, Endi, McDonnell, Donald P., Kang, Yubin

“…Many patients with multiple myeloma (MM) have comorbidities and are treated with PPAR agonists. Immunomodulatory agents (IMiDs) are the cornerstones for MM…”
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The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells by Baek, Amy E., Yu, Yen-Rei A., He, Sisi, Wardell, Suzanne E., Chang, Ching-Yi, Kwon, Sanghoon, Pillai, Ruchita V., McDowell, Hannah B., Thompson, J. Will, Dubois, Laura G., Sullivan, Patrick M., Kemper, Jongsook K., Gunn, Michael D., McDonnell, Donald P., Nelson, Erik R.

“…Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence, while the use of statins, cholesterol biosynthesis inhibitors…”
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Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer by Allensworth, Jennifer L., Evans, Myron K., Bertucci, François, Aldrich, Amy J., Festa, Richard A., Finetti, Pascal, Ueno, Naoto T., Safi, Rachid, McDonnell, Donald P., Thiele, Dennis J., Van Laere, Steven, Devi, Gayathri R.

“…Cancer cells often have increased levels of reactive oxygen species (ROS); however, acquisition of redox adaptive mechanisms allows for evasion of ROS-mediated…”
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The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer by McDonnell, Donald P, Wardell, Suzanne E

“…Our understanding of the molecular mechanisms underlying the pharmacological actions of estrogen receptor (ER) ligands has evolved considerably in recent…”
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Copper signaling axis as a target for prostate cancer therapeutics by Safi, Rachid, Nelson, Erik R, Chitneni, Satish K, Franz, Katherine J, George, Daniel J, Zalutsky, Michael R, McDonnell, Donald P

“…Previously published reports indicate that serum copper levels are elevated in patients with prostate cancer and that increased copper uptake can be used as a…”
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ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer by Park, Sunghee, Chang, Ching-Yi, Safi, Rachid, Liu, Xiaojing, Baldi, Robert, Jasper, Jeff S., Anderson, Grace R., Liu, Tingyu, Rathmell, Jeffrey C., Dewhirst, Mark W., Wood, Kris C., Locasale, Jason W., McDonnell, Donald P.

“…Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Furthermore, the extremely low…”
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The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis by Nelson, Erik R, Wardell, Suzanne E, McDonnell, Donald P

“…Abstract Estrogen therapy and hormone therapy are effective options for the prevention and treatment of osteoporosis, although because of their significant…”
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The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer by Chang, Ching-yi, Kazmin, Dmitri, Jasper, Jeff S., Kunder, Rebecca, Zuercher, William J., McDonnell, Donald P.

“…A genomic signature designed to assess the activity of the estrogen-related receptor alpha (ERRα) was used to profile more than 800 breast tumors, revealing a…”
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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors by Anderson, Gray R., Wardell, Suzanne E., Cakir, Merve, Yip, Catherine, Ahn, Yeong-ran, Ali, Moiez, Yllanes, Alexander P., Chao, Christina A., McDonnell, Donald P., Wood, Kris C.

“…Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we…”
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Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance by Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.

“…The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional activity using competitive antagonists, such as enzalutamide…”
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Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer by Haines, Corinne N, Wardell, Suzanne E, McDonnell, Donald P

“…Nearly 80% of all breast cancers are estrogen receptor positive (ER+) and require the activity of this transcription factor for tumor growth and survival…”
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Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma by Chakraborty, Binita, Byemerwa, Jovita, Shepherd, Jonathan, Haines, Corinne N, Baldi, Robert, Gong, Weida, Liu, Wen, Mukherjee, Debarati, Artham, Sandeep, Lim, Felicia, Bae, Yeeun, Brueckner, Olivia, Tavares, Kendall, Wardell, Suzanne E, Hanks, Brent A, Perou, Charles M, Chang, Ching-Yi, McDonnell, Donald P

“…Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly,…”
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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging by Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.

“…Androgen receptor (AR)‐dependent transcription is a major driver of prostate tumor cell proliferation. Consequently, it is the target of several antitumor…”
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product by Liberti, Maria V., Dai, Ziwei, Wardell, Suzanne E., Baccile, Joshua A., Liu, Xiaojing, Gao, Xia, Baldi, Robert, Mehrmohamadi, Mahya, Johnson, Marc O., Madhukar, Neel S., Shestov, Alexander A., Chio, Iok I. Christine, Elemento, Olivier, Rathmell, Jeffrey C., Schroeder, Frank C., McDonnell, Donald P., Locasale, Jason W.

“…Targeted cancer therapies that use genetics are successful, but principles for selectively targeting tumor metabolism that is also dependent on the environment…”
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