Search Results - "McDonald, Thomas S."

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement by Wolford, Angela, McDonald, Thomas S, Eng, Heather, Hansel, Steven, Chen, Yue, Bauman, Jonathan, Sharma, Raman, Kalgutkar, Amit S

“…The United States Public Health Service Administration is alerting medical professionals that a substantial percentage of cocaine imported into the United…”
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Impact of instrument and column parameters on high-throughput liquid chromatography performance by Gilar, Martin, McDonald, Thomas S., Gritti, Fabrice

“…•An LC system with short injection-to-injection analytical cycle time was assembled.•We evaluated the impact of the instrument, the column and the control…”
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Utility of linear and nonlinear models for retention prediction in liquid chromatography by Gilar, Martin, Hill, Jason, McDonald, Thomas S., Gritti, Fabrice

“…•MS Excel plots were used to illustrate the migration of analytes through the column.•Nonlinear ln k versus Φ relationship was observed for all types of RP-LC…”
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Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs by Eng, Heather, Sharma, Raman, McDonald, Thomas S., Landis, Margaret S., Stevens, Benjamin D., Kalgutkar, Amit S.

“…Abstract 1. Glucagon-like peptide-1 (GLP-1)(7-36)amide is a 30-amino acid peptide hormone that is secreted from intestinal enteroendocrine L-cells in response…”
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Experimental evaluation of chromatographic performance of capillary and microfluidic columns with linear or curved channels by Gilar, Martin, McDonald, Thomas S., Gritti, Fabrice

“…•We experimentally verified the theoretical relationship between column efficiency N and peak capacity Pc.•The relationship was utilized to estimate the column…”
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Solvent selectivity and strength in reversed-phase liquid chromatography separation of peptides by Gilar, Martin, Jaworski, Aleksander, McDonald, Thomas S.

“…•RP LC solvent selectivity was investigated using amino acid retention coefficients.•Trp, Phe, Tyr residues contribute less to peptide retention in MeOH than…”
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A novel relay method for determining low-clearance values by Di, Li, Trapa, Patrick, Obach, R Scott, Atkinson, Karen, Bi, Yi-An, Wolford, Angela C, Tan, Beijing, McDonald, Thomas S, Lai, Yurong, Tremaine, Larry M

“…A novel relay method has been developed using cryopreserved human hepatocytes to measure intrinsic clearance of low-clearance compounds. The relay method…”
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In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method by Di, Li, Atkinson, Karen, Orozco, Christine C, Funk, Carrie, Zhang, Hui, McDonald, Thomas S, Tan, Beijing, Lin, Jian, Chang, Cheng, Obach, R Scott

“…In vitro-in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support…”
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Wide injection zone compression in gradient reversed-phase liquid chromatography by Gilar, Martin, McDonald, Thomas S., Johnson, Jay S., Murphy, James P., Jorgenson, James W.

“…•On-column peak movements in gradient LC were simulated using simple Excel spreadsheets.•Zone broadening and compression effects were visualized by calculating…”
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Repetitive injection method: A tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography by Gilar, Martin, McDonald, Thomas S., Roman, Gregory, Johnson, Jay S., Murphy, James P., Jorgenson, James W.

“…•A repetitive injection method was developed to study wide injection zone generation and compression.•A spreadsheet was designed for the simulation of…”
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In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes by Sharma, Raman, McDonald, Thomas S, Eng, Heather, Limberakis, Chris, Stevens, Benjamin D, Patel, Sheena, Kalgutkar, Amit S

“…Previous studies have revealed that the glucoincretin hormone glucagon-like peptide-1 (GLP-1)(7-36)amide is metabolized by dipeptidyl peptidase-IV (DPP-IV) and…”
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Chromatographic performance of microfluidic liquid chromatography devices: Experimental evaluation of straight versus serpentine packed channels by Gilar, Martin, McDonald, Thomas S., Gritti, Fabrice, Roman, Gregory T., Johnson, Jay S., Bunner, Bernard, Michienzi, Joseph D., Collamati, Robert A., Murphy, Jim P., Satpute, Devesh D., Bannon, Matthew P., DellaRovere, Dennis, Jencks, Robert A., Dourdeville, Tad A., Fadgen, Keith E., Gerhardt, Geoff C.

“…•High-pressure compatible microfluidic (μLC) devices were micro-machined from titanium.•Straight and serpentine μLC columns with nominal i.d.’s of 0.15, 0.3…”
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Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans by Maciejewski, Benjamin S, LaPerle, Jennifer L, Chen, Danny, Ghosh, Avijit, Zavadoski, William J, McDonald, Thomas S, Manion, Tara B, Mather, Dawn, Patterson, Terrell A, Hanna, Maya, Watkins, Steven, Gibbs, E Michael, Calle, Roberto A, Steppan, Claire M

“…Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids and triglycerides (TG), have been implicated in the…”
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Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor by Eng, Heather, Sharma, Raman, McDonald, Thomas S, Edmonds, David J, Fortin, Jean-Philippe, Li, Xianping, Stevens, Benjamin D, Griffith, David A, Limberakis, Chris, Nolte, Whitney M, Price, David A, Jackson, Margaret, Kalgutkar, Amit S

“…4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP) represents a novel small-molecule activator of the glucagon-like peptide-1…”
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Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro by Kalgutkar, Amit S, Mascitti, Vincent, Sharma, Raman, Walker, Gregory W, Ryder, Tim, McDonald, Thomas S, Chen, Yue, Preville, Cathy, Basak, Arindrajit, McClure, Kim F, Kohrt, Jeffrey T, Robinson, Ralph P, Munchhof, Michael J, Cornelius, Peter

“…Isopropyl 9-anti-[5-cyano-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-3-oxa-7-aza-bicyclo[3.3.1]nonane-7-carboxylate (1) represents a prototypic compound…”
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