Search Results - "McDonald, Patrick P."

Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways by Tatsiy, Olga, McDonald, Patrick P

“…Neutrophils are known to extrude decondensed chromatin, thus forming NETs (neutrophil extracellular traps). These structures immobilize pathogens, thereby…”
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Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus by de Carvalho Oliveira, Vanessa, Tatsiy, Olga, McDonald, Patrick P

“…Neutrophil extracellular traps (NETs) serve to immobilize and kill pathogens, but also can contribute to the progression of several inflammatory and…”
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Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression by Wilhelm, Emmanuelle, Poirier, Mikaël, Da Rocha, Morgane, Bédard, Mikaël, McDonald, Patrick P, Lavigne, Pierre, Hunter, Christie L, Bell, Brendan

“…The human immunodeficiency virus (HIV) integrates into the host genome forming latent cellular reservoirs that are an obstacle for cure or remission…”
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Early and Late Processes Driving NET Formation, and the Autocrine/Paracrine Role of Endogenous RAGE Ligands by Tatsiy, Olga, de Carvalho Oliveira, Vanessa, Mosha, Hugo Tshivuadi, McDonald, Patrick P.

“…Neutrophil extracellular trap (NET) formation has emerged as an important response against various pathogens; it also plays a role in chronic inflammation,…”
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Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk by Tatsiy, Olga, Mayer, Thomas Z, de Carvalho Oliveira, Vanessa, Sylvain-Prévost, Stéphanie, Isabel, Marilyn, Dubois, Claire M, McDonald, Patrick P

“…Gout is a prevalent and incapacitating disease triggered by the deposition of monosodium urate (MSU) crystals in joints, which are also massively infiltrated…”
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Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis by McDonald, Patrick P., Leifer, Franziska Graf, Basso, Jessica, Lasala, Dan, Li, Dedong, Chen, Kuan-Ju, Zhang, Jimin, Perkins, Walter R., Cipolla, David C.

“…Rheumatoid arthritis (RA) is a painful and incurable disease characterized by chronic joint inflammation and a progressive destruction of cartilage and bone…”
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The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species by Basso, Jessica, Chen, Kuan-Ju, Zhou, Yuchen, Mark, Lilly, LaSala, Daniel, Dorfman, Arielle, Atalla, Mary, Chun, Donald, Viramontes, Veronica, Chang, Christina, Leifer, Franziska, McDonald, Patrick P, Cipolla, David C

“…Brensocatib is a novel, oral, selective, reversible inhibitor of dipeptidyl peptidase 1 (DPP1), which activates several neutrophil serine proteases (NSPs),…”
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Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice by Chen, Kuan-Ju, Zhang, Jimin, LaSala, Daniel, Basso, Jessica, Chun, Donald, Zhou, Yuchen, McDonald, Patrick P, Perkins, Walter R, Cipolla, David C

“…Neutrophils have been implicated in initiating and perpetuating systemic lupus erythematosus and the resultant kidney damage in lupus nephritis (LN) patients,…”
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Airway Mucins Inhibit Oxidative and Non-Oxidative Bacterial Killing by Human Neutrophils by Cantin, André M, Ouellet, Cristine, Cloutier, Alexandre, McDonald, Patrick P

“…Neutrophil killing of bacteria is mediated by oxidative and non-oxidative mechanisms. Oxidants are generated through the NADPH oxidase complex, whereas…”
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Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells by Sutton, Vivien R, Watt, Sally V, Akhlaghi, Hedieh, Cipolla, David C, Chen, Kuan-Ju, LaSala, Daniel, McDonald, Patrick P, Beavis, Paul A, Munoz, Isabelle, Hodel, Adrian W, Noori, Tahereh, Voskoboinik, Ilia, Trapani, Joseph A

“…Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress…”
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Inflammatory Cytokine Production by Human Neutrophils Involves C/EBP Transcription Factors by Cloutier, Alexandre, Guindi, Chantal, Larivee, Pierre, Dubois, Claire M, Amrani, Abdelaziz, McDonald, Patrick P

“…A growing number of neutrophil-derived cytokines have proven to be crucial to various inflammatory and immune processes in vivo. Whereas C/EBP…”
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The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils by Mayer, Thomas Z, Simard, François A, Cloutier, Alexandre, Vardhan, Harsh, Dubois, Claire M, McDonald, Patrick P

“…Neutrophils influence innate and adaptative immunity by generating numerous cytokines and chemokines whose regulation largely depends on transcriptional…”
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Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing by Charbonneau, Martine, Harper, Kelly, Brochu-Gaudreau, Karine, Perreault, Alexis, McDonald, Patrick P., Ekindi-Ndongo, Nadia, Jeldres, Claudio, Dubois, Claire M.

“…Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma accounting for the majority of deaths in kidney cancer patients…”
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New Insights into the Pro-Inflammatory Activities of Ang1 on Neutrophils: Induction of MIP-1β Synthesis and Release by Dumas, Elizabeth, Neagoe, Paul-Eduard, McDonald, Patrick P, White, Michel, Sirois, Martin G

“…We reported the expression of angiopoietin Tie2 receptor on human neutrophils and the capacity of angiopoietins (Ang1 and Ang2) to induce pro-inflammatory…”
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Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses by Sylvain-Prévost, Stéphanie, Ear, Thornin, Simard, François A, Fortin, Carl F, Dubois, Claire M, Flamand, Nicolas, McDonald, Patrick P

“…The MAP3 kinase, TAK1, is known to act upstream of IKK and MAPK cascades in several cell types, and is typically activated in response to cytokines (e.g., TNF,…”
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Translational control of human neutrophil responses by MNK1 by Fortin, Carl F., Mayer, Thomas Z., Cloutier, Alexandre, McDonald, Patrick P.

“…Cytokine production and delayed apoptosis are influenced by the TAK1‐p38‐MNK1 axis in neutrophils, which also affects molecules implicated in translation…”
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Human Neutrophils Generate Extracellular Vesicles That Modulate Their Functional Responses by Hurtado Gutiérrez, María José, Allard, Frédérick L, Mosha, Hugo Tshivuadi, Dubois, Claire M, McDonald, Patrick P

“…Neutrophils influence innate and adaptive immunity by releasing various cytokines and chemokines, by generating neutrophil extracellular traps (NETs), and by…”
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Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils by McDonald, Patrick P., Allard, Frédérick L., Tatsiy, Olga, Ear, Thornin

“…Neutrophils play a critical role in innate immunity and also influence adaptive immune responses. This occurs in good part through their production of…”
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Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells by Guindi, Chantal, Cloutier, Alexandre, Gaudreau, Simon, Zerif, Echarki, McDonald, Patrick P, Tatsiy, Olga, Asselin, Claude, Dupuis, Gilles, Gris, Denis, Amrani, And Abdelaziz

“…Dendritic cells (DCs) play a major role in innate and adaptive immunity and self-immune tolerance. Immunogenic versus tolerogenic DC functions are dictated by…”
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Differential involvement of NF-κB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils by Cloutier, Alexandre, Ear, Thornin, Blais‐Charron, Emilie, Dubois, Claire M., McDonald, Patrick P.

“…The ability of human neutrophils to express a variety of genes encoding inflammatory mediators is well documented, and mounting evidence suggests that…”
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