Search Results - "McDonald, N.Q."

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing by McDonald, N.Q., Panayotatos, N., Hendrickson, W.A.

“…Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating…”
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Crystal structure of a γ-herpesvirus cyclin-cdk complex by Card, G.L., Knowles, P., Laman, H., Jones, N., McDonald, N.Q.

“…Several γ‐herpesviruses encode proteins related to the mammalian cyclins, regulatory subunits of cyclin‐dependent kinases (cdks) essential for cell cycle…”
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Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy by Plaza-Menacho, I., Mologni, L., McDonald, N.Q.

“…De-regulation of RET signaling by oncogenic mutation, gene rearrangement, overexpression or transcriptional up-regulation is implicated in several human…”
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Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency by Grey, W., Chauhan, R., Piganeau, M., Huerga Encabo, H., Garcia-Albornoz, M., McDonald, N.Q., Bonnet, D.

“…Expansion of human hematopoietic stem cells (HSCs) is a rapidly advancing field showing great promise for clinical applications. Recent evidence has implicated…”
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Structural basis for the RPEL motif interaction with G-actin by Mouilleron, S., Guettler, S., Treisman, R., McDonald, N.Q.

“…Abstract only…”
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Characterization and crystallization of recombinant human neurotrophin-4 by FANDL, J. P, TOBKES, N. J, MCDONALD, N. Q, HENDRICKSON, W. A, RYAN, T. E, SOMESH NIGAM, ACHESON, A, CUDNY, H, PANAYOTATOS, N

“…Neurotrophin-4 (NT-4) is the most recently discovered member of the neurotrophin family. We have expressed, refolded, and purified recombinant human NT-4 from…”
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Functional analysis of mutant neurotrophins deficient in low‐affinity binding reveals a role for p75LNGFR in NT‐4 signalling by Rydén, M., Murray‐Rust, J., Glass, D., Ilag, L.L., Trupp, M., Yancopoulos, G.D., McDonald, N.Q., Ibáñez, C.F.

“…The neurotrophins mediate their effects through binding to two classes of receptors, a tyrosine kinase receptor, member of the Trk family, and the low‐affinity…”
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Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF) by McDonald, N Q, Blundell, T L

“…A high molecular weight form of nerve growth factor (7 S NGF) has been crystallized in two crystal forms from polyethylene glycol 4000 by the vapour diffusion…”
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