Search Results - "McDonald, Mirna"

Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects by Schneider, Frank, Erisson, Lavi, Beygi, Hooman, Bradbury, Margaret, Cohen‐Barak, Orit, Grachev, Igor D., Guzy, Serge, Loupe, Pippa S., Levi, Micha, McDonald, Mirna, Savola, Juha‐Matti, Papapetropoulos, Spyros, Tracewell, William G., Velinova, Maria, Spiegelstein, Ofer

“…Aims SD‐1077, a selectively deuterated precursor of dopamine (DA) structurally related to L‐3,4‐dihydroxyphenylalanine (L‐DOPA), is under development for…”
Get full text

Reslizumab as add-on therapy in patients with refractory asthma by Virchow, J Christian, McDonald, Mirna, Garin, Margaret, Korn, Stephanie

“…Approximately 5%–10% of patients with asthma are believed to suffer from severe disease.4 Patients with severe asthma typically require ongoing maintenance…”
Get full text

Tafenoquine at therapeutic concentrations does not prolong fridericia-corrected QT interval in healthy subjects by Green, Justin A., Patel, Apurva K., Patel, Bela R., Hussaini, Azra, Harrell, Emma J., McDonald, Mirna J., Carter, Nick, Mohamed, Khadeeja, Duparc, Stephan, Miller, Ann K.

“…Tafenoquine is being developed for relapse prevention in Plasmodium vivax malaria. This Phase I, single‐blind, randomized, placebo‐ and active‐controlled…”
Get full text

Reslizumab improves FVC and FEF 25%-75% in severe eosinophilic asthma: results from a pooled analysis by Carr, Warner W., McDonald, Mirna, Meizlik, Paige

Get full text

Early decreases in blood eosinophil levels with reslizumab by Chanez, Pascal, McDonald, Mirna, Garin, Margaret, Murphy, Kevin

“…Detailed description of the study designs has been reported previously.5 In brief, eligible patients were aged 12 to 75 years with inadequately controlled…”
Get full text

Fremanezumab Decreases Migraine Symptoms such as Nausea, Vomiting, Photophobia and Phonophobia and Reduces the Need for Acute Medications in the First Week of Treatment in the HFEM Study (P4.111) by Bigal, Marcelo, McDonald, Mirna, Aycardi, Ernesto, Loupe, Pippa, Noble, Robert

“…Abstract only…”
Get full text

Fremanezumab Reduces Headache Pain within the First Week of Beginning Treatment in the Phase 2 Episodic Migraine Study (P4.114) by Bigal, Marcelo, Aycardi, Ernesto, McDonald, Mirna, Noble, Robert, Loupe, Pippa

“…Abstract only…”
Get full text

Reslizumab improves FVC and FEF25%-75% in severe eosinophilic asthma: results from a pooled analysis by Carr, Warner W., McDonald, Mirna, Meizlik, Paige

“…Rationale IV reslizumab (RES), a humanized anti-interleukin-5 monoclonal antibody, demonstrated significant improvement in FEV1 at 52 weeks in patients aged…”
Get full text

Baseline Characteristics Associated with Quartiles of Reslizumab Effect: Pooled Analysis Of Two Phase 3 Studies by Chipps, Bradley E., McDonald, Mirna, Garin, Margaret

“…Rationale IV reslizumab (RES), a humanized anti-interleukin-5 monoclonal antibody, significantly reduced risk of asthma exacerbations and improved asthma…”
Get full text

Improvements In Individual Asthma Control Questionnaire (ACQ-5) Questions With Reslizumab In Patients With Inadequately Controlled Asthma and Elevated Blood Eosinophils: Pooled Analysis of Two Phase 3 Trials by Korenblat, Phillip E., McDonald, Mirna, Garin, Margaret

“…Results Compared to PBO (n=475), RES (n=477) resulted in improvement in Q1 (nighttime awakenings [NA]) by -0.3, Q2 (morning symptoms [MS]) by -0.5, Q3…”
Get full text

Association Between Asthma Exacerbations and Lung Function With Reslizumab Treatment In Patients With Uncontrolled Eosinophilic Asthma: Pooled Analysis of Two Phase 3 Trials by Fahrenholz, John M., McDonald, Mirna, Garin, Margaret

“…Rationale Reslizumab (RES), a humanized anti-interleukin-5 monoclonal antibody, significantly reduced the risk of clinical asthma exacerbation (CAE) in…”
Get full text

The Effect of Beginning Treatment With Fremanezumab on Headache and Associated Symptoms in the Randomized Phase 2 Study of High Frequency Episodic Migraine: Post‐Hoc Analyses on the First 3 Weeks of Treatment by Silberstein, Stephen D., Rapoport, Alan M., Loupe, Pippa S., Aycardi, Ernesto, McDonald, Mirna, Yang, Ronghua, Bigal, Marcelo E.

“…Background Migraine has a substantial impact on daily living, affecting productivity and quality of life for patients and their families. Patients frequently…”
Get full text

Sustained reductions in migraine days, moderate-to-severe headache days and days with acute medication use for HFEM and CM patients taking fremanezumab: Post-hoc analyses from phase 2 trials by Halker Singh, Rashmi B, Aycardi, Ernesto, Bigal, Marcelo E, Loupe, Pippa S, McDonald, Mirna, Dodick, David W

“…In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and…”
Get more information

Safety of Reslizumab in Uncontrolled Asthma with Eosinophilia: A Pooled Analysis from 6 Trials by Virchow, J. Christian, Katial, Rohit, Brusselle, Guy G., Shalit, Yael, Garin, Margaret, McDonald, Mirna, Castro, Mario

“…Intravenous reslizumab, a monoclonal IL-5 antibody, is approved for treating severe asthma with eosinophilia. Limited structured information is available on…”
Get full text

Efficacy of Reslizumab in Asthma Patients with Aspirin Sensitivity and Elevated Blood Eosinophils by Katial, Rohit, Hoyte, Flavia, Germinaro, Matthew, MD, McDonald, Mirna

“…Conclusions Patients with inadequately controlled asthma, elevated blood eosinophils, and ASA sensitivity (±CRSwNP) received significant therapeutic benefit,…”
Get full text

Effects of Reslizumab on Asthma Outcomes in a Subgroup of Eosinophilic Asthma Patients with Self-Reported Chronic Rhinosinusitis with Nasal Polyps by Weinstein, Steven F., Katial, Rohit K., Bardin, Philip, Korn, Stephanie, McDonald, Mirna, Garin, Margaret, Bateman, Eric D., Hoyte, Flavia C.L., Germinaro, Matthew

“…An estimated 7% of patients with asthma have chronic rhinosinusitis with nasal polyps (CRSwNP), and more than 80% have at least some radiographic evidence of…”
Get full text