Search Results - "McDonald, John P"

Pathogen-encoded Rum DNA polymerase drives rapid bacterial drug resistance by Jaszczur, Malgorzata M, Pham, Phuong, Ojha, Debika, Pham, Cecilia Q, McDonald, John P, Woodgate, Roger, Goodman, Myron F

“…The acquisition of multidrug resistance by pathogenic bacteria is a potentially incipient pandemic. Horizontal transfer of DNA from mobile integrative…”
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Removal of misincorporated ribonucleotides from prokaryotic genomes: an unexpected role for nucleotide excision repair by Vaisman, Alexandra, McDonald, John P, Huston, Donald, Kuban, Wojciech, Liu, Lili, Van Houten, Bennett, Woodgate, Roger

“…Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast,…”
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DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli by Henrikus, Sarah S, Wood, Elizabeth A, McDonald, John P, Cox, Michael M, Woodgate, Roger, Goodman, Myron F, van Oijen, Antoine M, Robinson, Andrew

“…In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in motion a series of different DNA repair and damage tolerance pathways…”
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Regulation of Mutagenic DNA Polymerase V Activation in Space and Time by Robinson, Andrew, McDonald, John P, Caldas, Victor E A, Patel, Meghna, Wood, Elizabeth A, Punter, Christiaan M, Ghodke, Harshad, Cox, Michael M, Woodgate, Roger, Goodman, Myron F, van Oijen, Antoine M

“…Spatial regulation is often encountered as a component of multi-tiered regulatory systems in eukaryotes, where processes are readily segregated by organelle…”
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Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair by Henrikus, Sarah S, Henry, Camille, McGrath, Amy E, Jergic, Slobodan, McDonald, John P, Hellmich, Yvonne, Bruckbauer, Steven T, Ritger, Matthew L, Cherry, Megan E, Wood, Elizabeth A, Pham, Phuong T, Goodman, Myron F, Woodgate, Roger, Cox, Michael M, van Oijen, Antoine M, Ghodke, Harshad, Robinson, Andrew

“…Abstract Several functions have been proposed for the Escherichia coli DNA polymerase IV (pol IV). Although much research has focused on a potential role for…”
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Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis by Schuurs, Zachariah P, McDonald, John P, Croft, Laura V, Richard, Derek J, Woodgate, Roger, Gandhi, Neha S

“…As antibiotic resistance has become more prevalent, the social and economic impacts are increasingly pressing. Indeed, bacteria have developed the SOS response…”
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Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity by Vaisman, Alexandra, Kuban, Wojciech, McDonald, John P, Karata, Kiyonobu, Yang, Wei, Goodman, Myron F, Woodgate, Roger

“…The active form of Escherichia coli DNA polymerase V responsible for damage-induced mutagenesis is a multiprotein complex (UmuD'(2)C-RecA-ATP), called pol V…”
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Mechanisms employed by Escherichia coli to prevent ribonucleotide incorporation into genomic DNA by Pol V by McDonald, John P, Vaisman, Alexandra, Kuban, Wojciech, Goodman, Myron F, Woodgate, Roger

“…Escherichia coli pol V (UmuD'(2)C), the main translesion DNA polymerase, ensures continued nascent strand extension when the cellular replicase is blocked by…”
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Pressure Transducer Measurement Variability in Deep Wells Screened Across the Water Table by McDonald, John P

“…Automated water level measurements collected using vented pressure transducers in deep wells screened across the water table may exhibit a greater response to…”
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A strategy for the expression of recombinant proteins traditionally hard to purify by Frank, Ekaterina G., McDonald, John P., Karata, Kiyonobu, Huston, Donald, Woodgate, Roger

“…We have developed a series of plasmid vectors for the soluble expression and subsequent purification of recombinant proteins that have historically proven to…”
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DNA polymerase switching: effects on spontaneous mutagenesis in Escherichia coli by Curti, Elena, McDonald, John P, Mead, Samantha, Woodgate, Roger

“…Escherichia coli possesses five known DNA polymerases (pols). Pol III holoenzyme is the cell's main replicase, while pol I is responsible for the maturation of…”
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Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus by Vaisman, Alexandra, McDonald, John P, Smith, Mallory R, Aspelund, Sender L, Evans, Jr, Thomas C, Woodgate, Roger

“…Y-family DNA polymerases (pols) consist of six phylogenetically separate subfamilies; two UmuC (polV) branches, DinB (pol IV, Dpo4, polκ), Rad30A/POLH (polη),…”
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Measuring a Low Horizontal Hydraulic Gradient in a High Transmissivity Aquifer by McDonald, John P.

“…High transmissivity aquifers typically have low hydraulic gradients (i.e., a flat water table). Measuring low gradients using water levels can be problematic…”
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Escherichia coli UmuC active site mutants: Effects on translesion DNA synthesis, mutagenesis and cell survival by Kuban, Wojciech, Vaisman, Alexandra, McDonald, John P., Karata, Kiyonobu, Yang, Wei, Goodman, Myron F., Woodgate, Roger

“…► “Steric gate” mutants of E. coli pol V have been characterized in vitro and in vivo. ► UmuC F10L mutant exhibits low UV-mutability because the enzyme…”
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Corrigendum: Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus by Vaisman, Alexandra, McDonald, John P, Smith, Mallory R, Aspelund, Sender L, Evans, Jr, Thomas C, Woodgate, Roger

“…[This corrects the article DOI: 10.3389/fmolb.2021.778400.]…”
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The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism by McDonald, J.P. (NIH, Bethesda, MD.), Levine, A.S, Woodgate, R

“…Damage-inducible mutagenesis in prokaryotes is largely dependent upon the activity of the UmuD'C-like proteins. Since many DNA repair processes are…”
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CroSR391, an ortholog of the λ Cro repressor, plays a major role in suppressing polVR391‐dependent mutagenesis by McDonald, John P., Quiros, Dominic R., Vaisman, Alexandra, Mendez, Antonio R., Reyelt, Jan, Schmidt, Marlen, Gonzalez, Martín, Woodgate, Roger

“…When subcloned into low‐copy‐number expression vectors, rumAB, encoding polVR391 (RumA′2B), is best characterized as a potent mutator giving rise to high…”
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Insights into the complex levels of regulation imposed on Escherichia coli DNA polymerase V by Goodman, Myron F., McDonald, John P., Jaszczur, Malgorzata M., Woodgate, Roger

“…It is now close to 40 years since the isolation of non-mutable umu/uvm strains of Escherichia coli and the realization that damage induced mutagenesis in…”
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CroS R391 , an ortholog of the λ Cro repressor, plays a major role in suppressing polV R391 -dependent mutagenesis by McDonald, John P, Quiros, Dominic R, Vaisman, Alexandra, Mendez, Antonio R, Reyelt, Jan, Schmidt, Marlen, Gonzalez, Martín, Woodgate, Roger

“…When subcloned into low-copy-number expression vectors, rumAB, encoding polV (RumA' B), is best characterized as a potent mutator giving rise to high levels of…”
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The effect of entrepreneurial marketing on outcome goals in SMEs by Richard C. Becherer, Marilyn M. Helms, John P. McDonald

“…This study examines how entrepreneurial marketing dimensions (proactiveness, opportunity focused, leveraging, innovativeness, risk taking, value creation, and…”
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