Search Results - "McDonald, Jeffrey G."

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation by Dang, Eric V., McDonald, Jeffrey G., Russell, David W., Cyster, Jason G.

“…Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP…”
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Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis by Xia, Jonathan Y., Holland, William L., Kusminski, Christine M., Sun, Kai, Sharma, Ankit X., Pearson, Mackenzie J., Sifuentes, Angelica J., McDonald, Jeffrey G., Gordillo, Ruth, Scherer, Philipp E.

“…Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. We have developed transgenic mice inducibly expressing…”
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25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon by Reboldi, Andrea, Dang, Eric V., McDonald, Jeffrey G., Liang, Guosheng, Russell, David W., Cyster, Jason G.

“…Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive influence on inflammation. Here, we report that activated…”
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Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine by Trinh, Michael N., Brown, Michael S., Goldstein, Joseph L., Han, Jaeil, Vale, Gonçalo, McDonald, Jeffrey G., Seemann, Joachim, Mendell, Joshua T., Lu, Feiran

“…Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which releases cholesterol in lysosomes. The cholesterol moves…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth by Wu, Qian, Ishikawa, Tomonori, Sirianni, Rosa, Tang, Hao, McDonald, Jeffrey G., Yuhanna, Ivan S., Thompson, Bonne, Girard, Luc, Mineo, Chieko, Brekken, Rolf A., Umetani, Michihisa, Euhus, David M., Xie, Yang, Shaul, Philip W.

“…To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite…”
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Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis by Zhang, Chenlu, Chinnappan, Mahendran, Prestwood, Courtney A., Edwards, Marshall, Artami, Methinee, Thompson, Bonne M., Eckert, Kaitlyn M., Vale, Goncalo, Zouboulis, Christos C., McDonald, Jeffrey G., Harris-Tryon, Tamia A.

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of…”
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Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance by Radhakrishnan, Arun, Goldstein, Joseph L., McDonald, Jeffrey G., Brown, Michael S.

“…Animal cells control their membrane lipid composition within narrow limits, but the sensing mechanisms underlying this control are largely unknown. Recent…”
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A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma by McDonald, Jeffrey G., Smith, Daniel D., Stiles, Ashlee R., Russell, David W.

“…We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of…”
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Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition by Long, Tao, Hassan, Abdirahman, Thompson, Bonne M, McDonald, Jeffrey G, Wang, Jiawei, Li, Xiaochun

“…3-β-hydroxysteroid-Δ 8 , Δ 7 -isomerase, known as Emopamil-Binding Protein (EBP), is an endoplasmic reticulum membrane protein involved in cholesterol…”
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Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer by Bartolacci, Caterina, Andreani, Cristina, Vale, Gonçalo, Berto, Stefano, Melegari, Margherita, Crouch, Anna Colleen, Baluya, Dodge L., Kemble, George, Hodges, Kurt, Starrett, Jacqueline, Politi, Katerina, Starnes, Sandra L., Lorenzini, Daniele, Raso, Maria Gabriela, Solis Soto, Luisa M., Behrens, Carmen, Kadara, Humam, Gao, Boning, Wistuba, Ignacio I., Minna, John D., McDonald, Jeffrey G., Scaglioni, Pier Paolo

“…Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not…”
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Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways by Mitsche, Matthew A, McDonald, Jeffrey G, Hobbs, Helen H, Cohen, Jonathan C

“…Two parallel pathways produce cholesterol: the Bloch and Kandutsch-Russell pathways. Here we used stable isotope labeling and isotopomer analysis to trace…”
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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer by Monk, Brian C., Tomasiak, Thomas M., Keniya, Mikhail V., Huschmann, Franziska U., Tyndall, Joel D. A., O'Connell, Joseph D., Cannon, Richard D., McDonald, Jeffrey G., Rodriguez, Andrew, Finer-Moore, Janet S., Stroud, Robert M.

“…Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cell signaling, and morphogenesis. Complete monospanning…”
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Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling by CHENDONG YANG, SUDDERTH, Jessica, TUYEN DANG, BACHOO, Robert G, MCDONALD, Jeffrey G, DEBERARDINIS, Ralph J

“…Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to…”
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Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis by Zhang, Xinbo, McDonald, Jeffrey G., Aryal, Binod, Canfrán-Duque, Alberto, Goldberg, Emily L., Araldi, Elisa, Ding, Wen, Fan, Yuhua, Thompson, Bonne M., Singh, Abhishek K., Li, Qian, Tellides, George, Ordovás-Montanes, Jose, Milian, Rolando García, Dixit, Vishwa Deep, Ikonen, Elina, Suárez, Yajaira, Fernández-Hernando, Carlos

“…Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli…”
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Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol by Trinh, Michael N, Brown, Michael S, Seemann, Joachim, Vale, Gonçalo, McDonald, Jeffrey G, Goldstein, Joseph L, Lu, Feiran

“…Low-density lipoprotein (LDL) delivers cholesterol to mammalian cells through receptor-mediated endocytosis. The LDL cholesterol is liberated in lysosomes and…”
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Cilia-Associated Oxysterols Activate Smoothened by Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.

“…Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely…”
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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling by Kinnebrew, Maia, Iverson, Ellen J, Patel, Bhaven B, Pusapati, Ganesh V, Kong, Jennifer H, Johnson, Kristen A, Luchetti, Giovanni, Eckert, Kaitlyn M, McDonald, Jeffrey G, Covey, Douglas F, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat

“…Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol…”
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Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses by Spann, Nathanael J., Garmire, Lana X., McDonald, Jeffrey G., Myers, David S., Milne, Stephen B., Shibata, Norihito, Reichart, Donna, Fox, Jesse N., Shaked, Iftach, Heudobler, Daniel, Raetz, Christian R.H., Wang, Elaine W., Kelly, Samuel L., Sullards, M. Cameron, Murphy, Robert C., Merrill, Alfred H., Brown, H. Alex, Dennis, Edward A., Li, Andrew C., Ley, Klaus, Tsimikas, Sotirios, Fahy, Eoin, Subramaniam, Shankar, Quehenberger, Oswald, Russell, David W., Glass, Christopher K.

“…Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to…”
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages by Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

“…Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models…”
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