Search Results - "McDonald, Edith"

Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains by Zhao, Chen, Sham, Hing L., Sun, Minghua, Stoll, Vincent S., Stewart, Kent D., Lin, Shuqun, Mo, Hongmei, Vasavanonda, Sudthida, Saldivar, Ayda, Park, Chang, McDonald, Edith J., Marsh, Kennan C., Klein, Larry L., Kempf, Dale J., Norbeck, Daniel W.

“…As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic…”
Get full text

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P 2 ligands by Chen, Xiaoqi, Kempf, Dale J., Li, Lin, Sham, Hing L., Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

Get full text

Synthesis and antitumor activity of structural analogs of the epipodophyllotoxins by Klein, Larry L, Yeung, Clinton M, Chu, Daniel T, McDonald, Edith J, Clement, Jacob J, Plattner, Jacob J

“…Several ring-contracted analogues of the antitumor agent etoposide have been prepared. The synthesis of the simple indanyl system 3 is described along with two…”
Get full text

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease by SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir by KEMPF, D. J, MARSH, K. C, SUN, E, PIZZUTI, D, PLATTNER, J. J, NORBECK, D. W, LEONARD, J. M, KUMAR, G, RODRIGUES, A. D, DENISSEN, J. F, MCDONALD, E, KUKULKA, M. J, HSU, A, GRANNEMAN, G. R, BAROLDI, P. A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans by Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.

“…Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the…”
Get full text

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy by Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W

“…The structure−activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately…”
Get full text

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands by XIAOQI CHEN, KEMPF, Dale J, LIN LI, SHAM, Hing L, VASAVANONDA, Sudthida, WIDEBURG, Norman E, SALDIVAR, Ayda, MARSH, Kennan C, MCDONALD, Edith, NORBECK, Daniel W

“…Isopropyl substituted 4-thioazolyl valine side chains are highly optimized P(2)-P(3) ligands for C2 symmetry-based HIV protease inhibitors, as exemplified by…”
Get full text

A Novel, Picomolar Inhibitor of Human Immunodeficiency Virus Type 1 Protease by Sham, Hing L, Zhao, Chen, Stewart, Kent D, Betebenner, David A, Lin, Shuqun, Park, Chang H, Kong, Xiang-P, Rosenbrook, William, Herrin, Thomas, Madigan, Darold, Vasavanonda, Suthida, Lyons, Nicholas, Molla, Akhter, Saldivar, Ayda, Marsh, Kennan C, McDonald, Edith, Wideburg, Norman E, Denissen, Jon F, Robins, Terrel, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W

“…The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1)…”
Get full text

Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors by Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

Get full text

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P 3 ligands by Chen, Xiaoqi, Kempf, Dale J., Sham, Hing L., Green, Brian E., Molla, Akhteruzaman, Korneyeva, Marina, Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

“…The 2-isopropyl thiazolyl group is a highly optimized P 3 ligand for C 2 symmetry-based HIV protease inhibitors, as exemplified in the drug ritonavir. Here we…”
Get full text

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel p3 ligands by XIAOQI CHEN, KEMPF, D. J, MCDONALD, E, NORBECK, D. W, SHAM, H. L, GREEN, B. E, MOLLA, A, KORNEYEVA, M, VASAVANONDA, S, WIDEBURG, N. E, SALDIVAR, A, MARSH, K. C

“…The 2-isopropyl thiazolyl group is a highly optimized P3 ligand for C2 symmetry-based HIV protease inhibitors, as exemplified in the drug ritonavir. Here we…”
Get full text

Evaluation of furofuran as a P 2 ligand for symmetry-based HIV protease inhibitors by Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

“…The hexahydrofurofuranyloxy group was evaluated as a conformationally constrained P 2 ligand for symmetry-based HIV protease inhibitors. A number of compounds…”
Get full text

Novel Azacyclic Ureas That Are Potent Inhibitors of HIV-1 Protease by Sham, Hing L., Zhao, Chen, Marsh, Kennan C., Betebenner, David A., Lin, Shuqun, Jr, William Rosenbrook, Herrin, Thomas, Li, Leping, Madigan, Darold, Vasavanonda, Suthida, Molla, Akhter, Saldivar, Ayda, McDonald, Edith, Wideburg, Norman E., Kempf, Dale, Norbeck, Daniel W., Plattner, Jacob J.

“…A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50= 4.1 to <0.5 nM) were synthesized. Aqueous solubilities of…”
Get full text

Potent Inhibitors of the HIV-1 Protease with Good Oral Bioavailabilities by Sham, H.L., Zhao, C., Marsh, K.C., Betebenner, D.A., Lin, S.Q., Mcdonald, E., Vasavanonda, S., Wideburg, N., Saldivar, A., Robins, T., Kempf, D.J., Plattner, J.J., Norbeck, D.W.

“…A series of novel pseudo-symmetrical and unsymmetrical inhibitors based on the backbone modification of a peptidomimetic were synthesized and found to be…”
Get full text

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease by Kempf, Dale J., Molla, Akhteruzzaman, Marsh, Kennan C., Park, Chang, Rodrigues, A.David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Flentge, Charles A., Muchmore, Steven, Wideburg, Norman E., Saldivar, Ayda, Cooper, Art, Kati, Warren M., Stewart, Kent D., Norbeck, Daniel W.

“…The biological and pharmacokinetic properties of the HIV protease inhibitor ritonavir and its D-valinyl diastereomer, A-117673, were found to be…”
Get full text

Determination of ritonavir, a new HIV protease inhibitor, in biological samples using reversed-phase high-performance liquid chromatography by Marsh, Kennan C, Eiden, Erin, McDonald, Edith

“…A simple, accurate and precise high-performance liquid chromatographic method has been developed for measurement of ritonavir concentrations in human plasma…”
Get full text

ASSOCIATE DEGREE NURSE EDUCATORS' PERCEPTION OF NEED FOR TRANSCULTURAL CONCEPTS IN NURSING EDUCATION by MCDONALD, VERA EDITH

“…Statement of the Problem. This study addresses the problem of identifying the perceptions of Associate Degree nurse educators toward the need for transcultural…”
Get full text